Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Secreted protein HRGDF73
    Patent number: 7053190
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: May 30, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • Tumor necrosis factor receptor-5
    Patent number: 7049402
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: May 23, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Reiner Gentz, Jian Ni, Steven M Ruben
  • 12 human secreted proteins
    Publication number: 20060099622
    Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 11, 2005
    Publication date: May 11, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Paul Young, Joseph Kenny, Henrik Olsen, Paul Moore, Ying-Fei Wei, John Greene, Steven Ruben, Ding Liu, Paul Crocker
  • 67 human secreted proteins
    Publication number: 20060099575
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 12, 2001
    Publication date: May 11, 2006
    Inventors: Steven Ruben, Ann Ferrie, Craig Rosen, Kimberly Florence, Kenneth Carter, Daniel Soppet, Guo-Liang Yu, Charles Florence, Paul Young, Jian Ni, Gregory Endress, Ping Feng, Fouad Janat, Charles Birse
  • Galectin 11
    Patent number: 7041803
    Abstract: The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: May 9, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Craig A. Rosen
  • 186 human secreted proteins
    Publication number: 20060084082
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 6, 2005
    Publication date: April 20, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Carrie Fischer, Reinhard Ebner, Laurie Brewer, Paul Moore, Yanggu Shi, David LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • 98 human secreted proteins
    Publication number: 20060079670
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 20, 2005
    Publication date: April 13, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • Chemotactic cytokine III
    Publication number: 20060073573
    Abstract: Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
    Type: Application
    Filed: October 6, 2005
    Publication date: April 6, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner Gentz, Guo-Liang Yu, Jeffrey Su, Patrick Dillon
  • NATURAL KILLER CELL ACTIVATING FACTOR II
    Publication number: 20060068463
    Abstract: The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Application
    Filed: July 11, 2002
    Publication date: March 30, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Haodong Li, Guo-Liang Yu, Reiner Gentz
  • Epidermal differentiation factor
    Publication number: 20060063922
    Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Application
    Filed: November 8, 2005
    Publication date: March 23, 2006
    Applicants: The University of Antwerp, Human Genome Sciences, Inc.
    Inventors: Jian Ni, Ping Feng, Patrick Dillon, Reiner Gentz, Joseph Merregaert, Patrick Smits
  • Leukocyte regulatory factors 1 and 2
    Publication number: 20060063924
    Abstract: The present invention relates to novel LRF-1 and LRF-2 proteins which are related to the CRISP family and a protein called “Neutrophil Inhibitory Factor (NIF)” isolated from the canine hookworm (Ancylostoma caninum) that potently inhibits CD11/CD18-dependent neutrophil function. In particular, isolated nucleic acid molecules are provided encoding the human LRF-1 and LRF-2 proteins. LRF-1 and LRF-2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of LRF-1 or LRF-2 activity. Also provided are diagnostic methods for detecting immune system or other LRF-1- or LRF-2-related disorders and therapeutic methods for treating such disorders.
    Type: Application
    Filed: November 15, 2005
    Publication date: March 23, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Jing-Shan Hu, Steven Ruben, Reiner Gentz
  • 83 human secreted proteins
    Publication number: 20060057582
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: August 21, 2003
    Publication date: March 16, 2006
    Inventors: Craig Rosen, George Komatsoulis, Charles Birse, Gil Choi, Henrik Olsen, Jian Ni, Adam Bell
  • Pancreas-derived plasminogen activator inhibitor
    Publication number: 20060045878
    Abstract: The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
    Type: Application
    Filed: February 3, 2005
    Publication date: March 2, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner Gentz, Steven Ruben, Y. Shi
  • Galectin 11
    Publication number: 20060039905
    Abstract: The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
    Type: Application
    Filed: October 11, 2005
    Publication date: February 23, 2006
    Applicants: Human Genome Sciences, Inc., La Jolla Institute for Allergy and Immunology
    Inventors: Jian Ni, Reiner Gentz, Craig Rosen, Fu-Tong Liu
  • 33 human secreted proteins
    Publication number: 20060036089
    Abstract: The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 3, 2005
    Publication date: February 16, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel Soppet, Paul Moore, Yanggu Shi, Steven Ruben, Craig Rosen, David LaFleur, Henrik Olsen, Reinhard Ebner, Kimberly Florence, Paul Young, George Komatsoulis, Jian Ni
  • 32 human secreted proteins
    Publication number: 20060025574
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 15, 2005
    Publication date: February 2, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Kenneth Carter, Patrick Dillon, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • Antibodies to Chemokine Alpha-5
    Publication number: 20060008882
    Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: September 13, 2005
    Publication date: January 12, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig Rosen, Steven Ruben
  • T1 receptor-like ligand I
    Publication number: 20050287606
    Abstract: The present invention concerns a novel T1R-like ligand I protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand I protein. T1R-like ligand I polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.
    Type: Application
    Filed: August 19, 2005
    Publication date: December 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner Gentz, Craig Rosen
  • Human tumor necrosis factor receptor TR10
    Publication number: 20050282217
    Abstract: The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
    Type: Application
    Filed: July 21, 2005
    Publication date: December 22, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig Rosen
  • Nucleic acids encoding tumor necrosis factor receptor TR10
    Patent number: 6969599
    Abstract: The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: November 29, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig A. Rosen