Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to tumor necrosis factor receptor 5
    Publication number: 20050255100
    Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
    Type: Application
    Filed: July 18, 2005
    Publication date: November 17, 2005
    Applicant: HUMAN GENOME SCIENCES, INC.
    Inventors: Ying-Fei Wei, Jian Ni, Reiner Gentz, Steven Ruben
  • Death domain containing receptor 4
    Publication number: 20050244857
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
    Type: Application
    Filed: March 10, 2005
    Publication date: November 3, 2005
    Inventors: Jian Ni, Craig Rosen, James Pan, Reiner Gentz, Vishva Dixit
  • Human tumor necrosis factor receptors TR13 and TR14
    Publication number: 20050244876
    Abstract: The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 3, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Kevin Baker, Steven Ruben, Paul Young
  • 90 human secreted proteins
    Publication number: 20050244845
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: November 12, 2004
    Publication date: November 3, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Daniel Soppet, Reinhard Ebner, Henrik Olsen, Paul Young, John Greene, Ann Ferrie, Guo-Liang Yu, Jian Ni, Craig Rosen, Laurie Brewer, Fouad Janat, Charles Birse
  • 27 human secreted proteins
    Publication number: 20050239099
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 14, 2004
    Publication date: October 27, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Jian Ni, Reinhard Ebner, Craig Rosen, Yanggu Shi, Charles Birse, Kimberly Florence, George Komatsoulis, David LaFleur, Paul Moore, Henrik Olsen, Paul Young
  • 67 human secreted proteins
    Publication number: 20050239059
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 12, 2001
    Publication date: October 27, 2005
    Inventors: Steven Ruben, Ann Ferrie, Craig Rosen, Kimberly Florence, Kenneth Carter, Daniel Soppet, Guo-Liang Yu, Charles Florence, Paul Young, Jian Ni, Gregory Endress, Ping Feng, Fouad Janat, Charles Birse
  • Human tumor necrosis receptor TR9
    Publication number: 20050239123
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Application
    Filed: June 9, 2005
    Publication date: October 27, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner Gentz
  • Death domain containing receptor 5
    Publication number: 20050233958
    Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
    Type: Application
    Filed: November 3, 2004
    Publication date: October 20, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner Gentz, Guo-Liang Yu, Craig Rosen
  • Human extracellular matrix-1
    Publication number: 20050227282
    Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
    Type: Application
    Filed: June 2, 2005
    Publication date: October 13, 2005
    Applicants: Human Genome Sciences, Inc., The University of Antwerp
    Inventors: Jian Ni, Ping Feng, Patrick Dillon, Reiner Gentz, Joseph Merregaert, Patrick Smits
  • Death domain containing receptors
    Patent number: 6951735
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: October 4, 2005
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Guo-Liang Yu, Jian Ni, Vishva Dixit, Reiner L. Gentz, Patrick J. Dillon
  • Human tumor necrosis factor receptors TR13 and TR14
    Patent number: 6951738
    Abstract: The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: October 4, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Kevin P. Baker, Steven M. Ruben, Paul E. Young
  • 70 human secreted proteins
    Publication number: 20050215775
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: November 2, 2004
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • 26 human secreted proteins
    Publication number: 20050214786
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: August 19, 2004
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Charles Birse, George Komatsoulis, Gil Choi, Henrik Olsen, Jian Ni, Kevin Baker, Craig Rosen, Steven Ruben, Michele Fiscella, Paul Moore, Ping Wei
  • 86 human secreted proteins
    Publication number: 20050214844
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: April 22, 2005
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Moore, Yanggu Shi, Craig Rosen, Steven Ruben, David Lafleur, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Paul Young, John Greene, Ann Ferrie, Guo-Liang Yu, Jian Ni, Ping Feng
  • VEGI, an inhibitor of angiogenesis and tumor growth
    Publication number: 20050214305
    Abstract: The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
    Type: Application
    Filed: December 14, 2004
    Publication date: September 29, 2005
    Applicants: Human Genome Sciences, Inc., Georgetown University Medical Center
    Inventors: Lu-Yuan Li, Yifan Zhai, Guo-Liang Yu, Jian Ni, Marc Lippman, Craig Rosen
  • Human tumor necrosis factor receptor TR9
    Patent number: 6949358
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: September 27, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • 89 human secreted proteins
    Publication number: 20050208602
    Abstract: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    Type: Application
    Filed: February 9, 2004
    Publication date: September 22, 2005
    Inventors: Craig Rosen, Kevin Baker, Charles Birse, Gil Choi, Michele Fiscella, George Komatsoulis, Paul Moore, Jian Ni, Henrik Olsen, Steven Ruben, Ping Wei, D. Roxanne Duan, Yanggu Shi
  • 29 human secreted proteins
    Publication number: 20050208619
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 29, 2004
    Publication date: September 22, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig Rosen, Steven Ruben, Reinhard Ebner, Roxanne Duan, Jian Ni, Daniel Soppet, Paul Moore, Yanggu Shi, David LaFleur, Henrik Olsen, Charles Birse, George Komatsoulis
  • Death domain containing receptor-4 antibodies
    Patent number: 6943020
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: September 13, 2005
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Craig A. Rosen, James G. Pan, Reiner L. Gentz, Vishva M. Dixit
  • Secreted protein HCE3C63
    Patent number: 6936691
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: August 30, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Michele Fiscella, Ping Wei, David W. LaFleur, Henrik S. Olsen, Kevin P. Baker, Reinhard Ebner, George A. Komatsoulis, Craig A. Rosen, Steven M. Ruben, Roxanne D. Duan, Paul E. Young, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Jian Ni, Daniel R. Soppet, Yanggu Shi