Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 62 human secreted proteins
    Publication number: 20030050442
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: January 18, 2002
    Publication date: March 13, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, George Komatsoulis, Craig A. Rosen, Daniel R. Soppet, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Reinhard Ebner, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Paul Young
  • Apoptosis related polynucleotides, polypeptides, and antibodies
    Publication number: 20030049732
    Abstract: The present invention relates to novel human apoptosis related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human apoptosis related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human apoptosis related polypeptides.
    Type: Application
    Filed: December 13, 2001
    Publication date: March 13, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Paul E. Young, Steven M. Ruben
  • 186 human secreted proteins
    Publication number: 20030049618
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 16, 2001
    Publication date: March 13, 2003
    Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw
  • 31 human secreted proteins
    Publication number: 20030050460
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: September 10, 2001
    Publication date: March 13, 2003
    Inventors: Jian Ni, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Kimberly A. Florence, Paul E. Young, Charles E. Birse, Kenneth C. Carter, George Komatsoulis
  • TM4SF polynucleotides, polypeptides, and antibodies
    Publication number: 20030050466
    Abstract: The present invention relates to novel human TM4SF polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human TM4SF polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human TM4SF polypeptides.
    Type: Application
    Filed: March 22, 2002
    Publication date: March 13, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Ping Fan, Viktor Roschke, Yanggu Shi, George A. Komatsoulis, Craig A. Rosen
  • Secreted protein HFEAF41
    Publication number: 20030050461
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 1, 2001
    Publication date: March 13, 2003
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • Secreted protein HEMCM42
    Patent number: 6531447
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: March 11, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
  • Secreted protein HCEJQ69
    Publication number: 20030044851
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: December 12, 2001
    Publication date: March 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Ying-Fei Wei, Paul E. Young, Kimberly A. Florence, Daniel R. Soppet, Laurie A. Brewer, Gregory A. Endress, Kenneth C. Carter, Michael Mucenski, Reinhard Ebner, David W. LaFleur, Henrik S. Olsen, Yanggu Shi, Paul A. Moore, George A. Komatsoulis
  • Human G-protein coupled receptors
    Publication number: 20030044898
    Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
    Type: Application
    Filed: December 21, 2001
    Publication date: March 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Yi Li, Liang Cao, Jian Ni, Reiner Gentz, Carol J. Bult, Granger G. Sutton, Craig A. Rosen
  • 67 Human secreted proteins
    Publication number: 20030045459
    Abstract: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 21, 2001
    Publication date: March 6, 2003
    Inventors: Steven M. Ruben, Ann M. Ferrie, Craig A. Rosen, Kimberly A. Florence, Kenneth C. Carter, Daniel R. Soppet, Guo-Liang Yu, Charles Florence, Paul E. Young, Jian Ni, Gregory A. Endress, Ping Feng, Fouad Janat
  • Galectin 9 and 10SV polynucleotides
    Publication number: 20030040081
    Abstract: The present invention relates to novel galectin 8, 9, 10 and 10SV proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 8, 9, 10 and 10SV proteins. Galectin 8, 9, 10 and 10SV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 8, 9, 10 or 10SV activity. Also provided are diagnostic and therapeutic methods.
    Type: Application
    Filed: September 6, 2002
    Publication date: February 27, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Serpin polynucleotides, polypeptides, and antibodies
    Publication number: 20030040097
    Abstract: The present invention relates to novel human serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human serpin polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human serpin polypeptides.
    Type: Application
    Filed: April 5, 2002
    Publication date: February 27, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni
  • Precerebellin-like protein
    Patent number: 6525174
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: February 25, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
  • Signal transduction pathway component polynucleotides, polypeptides, antibodies and methods based thereon
    Publication number: 20030036505
    Abstract: The present invention relates to newly identified human polynucleotides and the polypeptides encoded by these polynucleotides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human antigens. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human antigens.
    Type: Application
    Filed: September 20, 2001
    Publication date: February 20, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven C. Barash, Jian Ni, Steven M. Ruben, Craig A. Rosen, Paul E. Young, Larry R. Rohrschneider
  • Death domain containing receptor-4 antibodies
    Publication number: 20030036168
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
    Type: Application
    Filed: August 23, 2002
    Publication date: February 20, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig A. Rosen, James G. Pan, Reiner L. Gentz, Vishva M. Dixit
  • Uncoupling protein polynucleotides, polypeptides, and antibodies
    Publication number: 20030036646
    Abstract: The present invention relates to novel human uncoupling polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human uncoupling polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human uncoupling polypeptides.
    Type: Application
    Filed: April 5, 2002
    Publication date: February 20, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, George A. Komatsoulis, Craig A. Rosen, Daniel R. Soppet
  • Human endokine alpha
    Patent number: 6521742
    Abstract: The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: February 18, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen
  • 19 human secreted proteins
    Publication number: 20030027297
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: April 11, 2001
    Publication date: February 6, 2003
    Inventors: Michele Fiscella, Ping Wei, David W. LaFleur, Henrik S. Olsen, Kevin P. Baker, Reinhard Ebner, George A. Komatsoulis, Craig A. Rosen, Steven M. Ruben, Roxanne D. Duan, Paul E. Young, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Jian Ni, Daniel R. Soppet, Yanggu Shi
  • Seven transmembrane receptor polynucleotides, polypeptides, and antibodies
    Publication number: 20030028008
    Abstract: The present invention relates to novel human 7TM polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human 7TM polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human 7TM polypeptides.
    Type: Application
    Filed: April 5, 2002
    Publication date: February 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Daniel R. Soppet, Yi Li, Ping Fan
  • TUMOR NECROSIS FACTOR-GAMMA
    Publication number: 20030027284
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Application
    Filed: August 7, 1998
    Publication date: February 6, 2003
    Inventors: GUO-LIANG YU, JIAN NI, CRAIG A. ROSEN, JUN ZHANG