Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020173640
    Abstract: The present invention relates to novel human ADAM polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human ADAM polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human ADAM polypeptides.
    Type: Application
    Filed: April 19, 2002
    Publication date: November 21, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Gregg A. Hastings, Yanggu Shi, Ping Wei
  • Publication number: 20020173458
    Abstract: The present invention relates to novel human PTK polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human PTK polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human PTK polypeptides.
    Type: Application
    Filed: April 18, 2001
    Publication date: November 21, 2002
    Inventors: Steven M. Ruben, Yanggu Shi, Paul E. Young, Jian Ni
  • Patent number: 6482922
    Abstract: A human mammary transforming protein and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for inhibiting such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: November 19, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz
  • Publication number: 20020168729
    Abstract: The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
    Type: Application
    Filed: May 2, 2002
    Publication date: November 14, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen
  • Publication number: 20020168359
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Application
    Filed: January 10, 2002
    Publication date: November 14, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Patent number: 6479633
    Abstract: Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: November 12, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Jeffrey Y. Su, Haodong Li
  • Publication number: 20020165377
    Abstract: The present invention relates to novel human ADAM polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human ADAM polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human ADAM polypeptides.
    Type: Application
    Filed: April 19, 2002
    Publication date: November 7, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Ping Wei, Jian Ni, Gregg A. Hastings, Yanggu Shi
  • Publication number: 20020165384
    Abstract: The present invention relates to novel human steroid hormone receptor polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human steroid hormone receptor polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human steroid hormone receptor polypeptides.
    Type: Application
    Filed: March 22, 2002
    Publication date: November 7, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Yanggu Shi, Steven M. Ruben
  • Publication number: 20020164669
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 19, 2001
    Publication date: November 7, 2002
    Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
  • Publication number: 20020164692
    Abstract: The present invention relates to novel human immune system-related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human immune system-related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human immune system-related polypeptides.
    Type: Application
    Filed: September 12, 2001
    Publication date: November 7, 2002
    Inventors: Jian Ni, David Hilbert, Joseph J. Kenny, Paul A. Moore, Gil H. Choi, Daniel R. Soppet, Reinhard Ebner, Joachim R. Gruber, Gregory A. Endress, Steven M. Ruben
  • Publication number: 20020164684
    Abstract: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
    Type: Application
    Filed: January 10, 2001
    Publication date: November 7, 2002
    Inventors: Jian Ni, Guo-Liang Yu, Ping Fan, Reiner L. Gentz
  • Publication number: 20020165374
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: October 29, 2001
    Publication date: November 7, 2002
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • Patent number: 6475753
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: November 5, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel R. Soppet, Laurie A. Brewer, Gregory A. Endress, Kenneth C. Carter, Michael Mucenski, Reinhard Ebner, David W. Lafleur, Henrik Olsen, Yanggu Shi, Paul A. Moore, George Komatsoulis
  • Patent number: 6476195
    Abstract: The present invention relates to novel human secreted protein (HNFGF20). Polypeptides of the invention are duseful in dianosis and treatment of disorders affecting the immune system.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: November 5, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: George Komatsoulis, Craig A. Rosen, Steven M. Ruben, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Ying-Fei Wei, Jian Ni, Kimberly A. Florence, Paul Young, Laurie A. Brewer, Daniel R. Soppet, Gregory A. Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
  • Publication number: 20020160491
    Abstract: The present invention relates to novel human Serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human Serpin polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human Serpin polypeptides.
    Type: Application
    Filed: July 26, 2001
    Publication date: October 31, 2002
    Inventors: Jian Ni, Steven M. Ruben, Yanggu Shi
  • Publication number: 20020155539
    Abstract: The present invention relates to novel human calcium channel polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human calcium channel polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human calcium channel polypeptides.
    Type: Application
    Filed: January 18, 2002
    Publication date: October 24, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni, Yanggu Shi
  • Patent number: 6468768
    Abstract: The present invention relates to novel galectin 8, 9, 10 and 10SV proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 8, 9, 10 and 10SV proteins. Galectin 8, 9, 10 and 10SV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 8, 9, 10 or 10SV activity. Also provided are diagnostic and therapeutic methods.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: October 22, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Reiner L. Gentz, Steven M. Ruben
  • Publication number: 20020150583
    Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6&agr; & -6&bgr; proteins. TNFR-6&agr; & -6&bgr; polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6&agr; & -6&bgr; activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
    Type: Application
    Filed: August 24, 2001
    Publication date: October 17, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Reiner L. Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M. Ruben, Jian Ni, Ping Feng
  • Publication number: 20020151009
    Abstract: The present invention relates to novel human polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human polypeptides.
    Type: Application
    Filed: August 28, 2001
    Publication date: October 17, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Yanggu Shi, Reinhard Ebner, Steven M. Ruben
  • Publication number: 20020150534
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Application
    Filed: July 6, 2001
    Publication date: October 17, 2002
    Inventors: Guo-Liang Yu, Jian Ni, Craig A. Rosen, Jun Zhang