Patents by Inventor Jian Ni

Jian Ni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030027284
    Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
    Type: Application
    Filed: August 7, 1998
    Publication date: February 6, 2003
    Inventors: GUO-LIANG YU, JIAN NI, CRAIG A. ROSEN, JUN ZHANG
  • Publication number: 20030027132
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 4, 1998
    Publication date: February 6, 2003
    Inventors: STEVEN M. RUBEN, CRAIG A. ROSEN, CARRIE L. FISCHER, DANIEL R. SOPPET, KENNETH C. CARTER, DANIEL R. BEDNARIK, GREGORY A. ENDRESS, GUO-LIANG YU, JIAN NI, PING FENG, PAUL E. YOUNG, JOHN M. GREENE, ANN M. FERRIE, ROXANNE DUAN, JING-SHAN HU, KIMBERLY A. FLORENCE, HENRIK S. OLSEN, REINHARD EBNER, LAURIE A. BREWER, YANGGU SHI
  • Publication number: 20030028003
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 12, 2001
    Publication date: February 6, 2003
    Inventors: Craig A. Rosen, Ping Feng, Steven M. Ruben, Reinhard Ebner, Henrik S. Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter, Charles E. Birse
  • Publication number: 20030022338
    Abstract: The present invention relates to novel human KTPI polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human KTPI polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human KTPI polypeptides.
    Type: Application
    Filed: April 19, 2002
    Publication date: January 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Jian Ni
  • Publication number: 20030023070
    Abstract: The present invention relates to novel human attractin-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human attractin-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human attractin-like polypeptides.
    Type: Application
    Filed: March 1, 2002
    Publication date: January 30, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben, Paul E. Young
  • Publication number: 20030018180
    Abstract: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: January 31, 2002
    Publication date: January 23, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Roxanne Duan, Jing-Shan Hu, Kimberly Florence, Henrik S. Olsen, Reinhard Ebner, Lauie A. Brewer, Paul A. Moore, Yanggu Shi, David W. Lafleur, Jian Ni
  • Patent number: 6509173
    Abstract: The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR11, TR11SV1, and TR11SV2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR11, TR11SV1, and TR11SV2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR11, TR11SV1, and TR11SV2 receptors.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: January 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben
  • Patent number: 6509170
    Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: January 21, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner Gentz, Patrick J. Dillon
  • Patent number: 6506882
    Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: January 14, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Guo-Liang Yu, Jian Ni, Reiner Gentz, Patrick J. Dillon
  • Patent number: 6506569
    Abstract: The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides and anti-TR10 antibodies are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: January 14, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Craig A. Rosen
  • Patent number: 6503184
    Abstract: The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR11, TR11SV1, and TR11SV2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR11, TR11SV1, and TR11SV2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR11, TR11SV1, and TR11SV2 receptors.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: January 7, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Steven M. Ruben
  • Publication number: 20030003555
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 1, 2001
    Publication date: January 2, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat
  • Publication number: 20030004324
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: March 6, 2001
    Publication date: January 2, 2003
    Inventors: Craig A. Rosen, Steven M. Ruben, Ann M. Ferrie, Charles Florence, Paul E. Young, Guo-Liang Yu, Jian Ni
  • Publication number: 20020197701
    Abstract: The present invention relates to novel human serine protease polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human serine protease polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human serine protease polypeptides.
    Type: Application
    Filed: February 8, 2002
    Publication date: December 26, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Yanggu Shi, Steven M. Ruben, Jian Ni
  • Publication number: 20020198143
    Abstract: The present invention relates to novel human B7-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human B7-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human B7-like polypeptides.
    Type: Application
    Filed: February 23, 2001
    Publication date: December 26, 2002
    Inventors: Steven M. Ruben, Lieping Chen, Kevin P. Baker, Jian Ni
  • Publication number: 20020192749
    Abstract: The present invention relates to novel human human polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human human polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human human polypeptides.
    Type: Application
    Filed: October 3, 2001
    Publication date: December 19, 2002
    Inventors: Paul A. Moore, Timothy A. Coleman, Reiner L. Gentz, Patrick J. Dillon, Jian Ni, Yi Li, Gregory A. Endress, Daniel R. Soppet
  • Publication number: 20020192800
    Abstract: The present invention relates to novel human serine protease polypeptides and isolated nucleic acids containin g the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human serine protease polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human serine protease polypeptides.
    Type: Application
    Filed: April 19, 2002
    Publication date: December 19, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Yanggu Shi, Steven M. Ruben
  • Patent number: 6495322
    Abstract: The present invention relates to a novel molecule involved in the process of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human RAIDD protein and splice variants thereof—referred to as RAIDD-SV1 and RAIDD-SV2. RAIDD polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of RAIDD activity.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: December 17, 2002
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Vishva M. Dixit
  • Publication number: 20020183503
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: January 11, 2002
    Publication date: December 5, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Charles E. Birse, Roxanne D. Duan, Daniel R. Soppet, Craig A. Rosen, Yanggu Shi, David W. LaFleur, Henrik Olsen, Reinhard Ebner, Kimberly A. Florence, Jian Ni, Paul Young
  • Publication number: 20020182702
    Abstract: The present invention relates to novel human ADAM polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human ADAM polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human ADAM polypeptides.
    Type: Application
    Filed: September 19, 2001
    Publication date: December 5, 2002
    Inventors: Steven M. Ruben, Jian Ni, Gregg A. Hastings, Yanggu Shi, Ping Wei