Abstract: A method of enhancing the activity of lysosomal &agr;-Galactosidase A (&agr;-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: An electrical connector includes an insulative housing (1), a first set of contacts (3) connecting to a first powering device and a second set of contacts (5) connecting to a second powering device. The first set of contacts has a first contact (31) and a second contact (32). The second set of contacts has a third contact (51), a fourth contact (53), a fifth contact (54) and a connecting element (52). The third and the fifth contacts respectively have a first and a second bias terminals (516, 543). A first electrical circuit is formed by the second and the third contacts and the connecting element. A second electrical circuit is formed by the first, the fourth and the fifth contacts. The first and the second electrical circuits are respectively connected to circuit traces of a PCB through the first and the second bias terminals.

Abstract: An input/output port connector has an insulative housing (1), a plurality of conductive contacts (2) retained in the insulative housing (1) for surface mounting to a printed circuit board and a shell (3). The insulative housing (1) includes a pair of side arms (11) parallel to each other and an elongate body (12) defining a pair of slots (121) therein. The shell (3) includes a bottom plate (30), a top plate (31), a pair of side plates (32) projecting from the top plate (31) and a pair of connecting plates (33) joining the bottom plate (30) and the top plate (31). The bottom plate (30) defines a pair of angled engaging plates (301) for horizontally engaging with the slots (121) of the insulative housing (1) and preventing the shell (3) from displacing relative to the insulative housing (1).

Abstract: A Subscriber Identity Module connector (1) includes an insulative housing (10) having a front and a rear rows of recesses (11), a plurality of terminals (20) retained in the recesses with contact portions (21) extending beyond a top surface of the housing for being horizontally exerted on by a SIM card (40), and a grounding pin (30) retained in a front portion of the recess of the rear row with a transitional portion (311) extending upwardly and forwardly beyond the top surface of the housing for being horizontally exerted on by the SIM card. During insertion, a SIM card slides on the grounding pin and exerts horizontal force on the transitional portion of the grounding pin to form the working circuit after the contact pads of the card fully engage with the contact portions of the terminals.

Abstract: A battery connector in accordance with the present invention includes an insulative housing (20), a plurality of terminals (21) and a detecting contact (22) received in the housing. Each terminal has an engaging portion (210), a curved portion (212) extending out of the housing and a contacting portion (213). The detecting contact has an engaging portion (220) and a contacting portion (222), the contacting portion electrically connected with the curved portion of an associated terminal during normal use of a battery and, when the battery is about to be removed, the associated terminal disconnecting from the contacting portion of the detecting contact before the terminals disconnect from the battery.

Abstract: Method fore enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

Abstract: An electrical card connector (1) includes a top lid (10) and a contact module (12). The top lid comprises a metal cover (100) and a pair of elongated grip arms (101) at opposite sides of the metal cover. Each grip arm is separately formed by insert molding at opposite sides of the cover and includes a rail (106) and a rib (107) projecting from a side of the rail. A pivot (108) is provided at a distal end of the rail and a wedge (109) extends from a forward end of the rail opposite the pivot. The contact module includes an insulative housing (120) and plurality of contacts (121). A pair of shaft lids (114) and a pair of lock portions (129) extend rearwardly and forwardly from rear and front corners of the insulative housing. Each shaft lid has a pivot hole (125) for pivotably engaging with a pivot of the grip arms. In use, an electrical card (2) is inserted into the top lid and the top lid is rotated to a closed position.

Abstract: A method of enhancing the activity of lysosomal &agr;-Galactosidase A (&agr;-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: An RJ-45 receptacle connector (2) for preventing insertion of a noncomplementary plug connector therein includes a dielectric housing (4) defining a receiving space (44) therein, a terminal module (5), an anti-mismating mechanism (7), and front and back shields (6,1). The anti-mismating mechanism (7) includes a pair of spring member 71, each having a base (72) fixed to the dielectric housing, a resilient stem (73) extending forwardly through the sidewall into the receiving space, a curved portion (732) formed near a free end (724) of the stem, and a stop tongue (75) extending from the resilient stem into a channel (49) defined in an upper wall (42). A smaller, noncomplementary plug connector is blocked from entry by the stop tongues projecting into the channel. Entrance of the complementary connector however, forces the curved portions aside, which moves the stop tongues from the connector's path, allowing full insertion of the complementary connector.

Abstract: An electrical connector comprises an insulative housing, a front shell and a rear shell. The insulative housing defines a plurality of passageways for receiving terminals. A plurality of resilient strips stamped from opposite walls of the front shell press against an inserted mating connector. A guiding portion is formed on the end of each forward edge of the front shell to guide a mating electrical connector. A rear section of the insulative housing is received in the rear shell and a front section of the insulative housing is received in the receiving opening of the front shell. A pair of tabs on the top rear of the front shell engages with a pair of corresponding first recesses on a top front of the rear shell and a pair of corresponding second recesses defined in the insulative housing. A plurality of latching fingers extending from inserting plates of the front shell engages with corresponding apertures in the rear shell.

Abstract: An electrical connector comprises an insulative housing, a number of conductive contacts, a shell and a rear cover. Receiving slots are disposed in the insulative housing for receiving the conductive contacts. Positioning grooves are defined at a rear lower side of the insulative housing, and a number of bumps are disposed on opposite inside surfaces thereof to interferingly retain soldering sections of the conductive contacts. A stabilization device, stamped and formed from a bottom forward surface of the shell, aids in providing a stable mounting of the electrical connector on the printed circuit board. Thus the electrical connector is prevented from slanting forward on its mounting, assuring proper operation.

Abstract: The apparatus for preparing quartz micropipettes includes a pair of carriers mounted on a linear ball bearing guide which grasp opposite ends of a quartz glass capillary tube. A pair of miniature torches fueled by a mixture of oxygen and propane simultaneously heat a portion of the center of the capillary tube and an inverted U-shaped bar disposed between the torches in propinquity to the capillary tube. A cable having one end attached to one of the carriers and the other end attached to the core of a solenoid, the intermediate portion of the cable being wound around a pulley and attached to the second carrier, is used to pull the capillary tube in opposite directions as the tube softens. The cable is also wound around the axle of an optical encoder assembly which sends an electrical signal to a computer based upon either the distance or velocity at which the tubing is pulled apart.

Abstract: To provide a process for producing a carbohydrate or a glycoconjugate without forming any hydrolytic product of the remodeled sugar chain.A process for producing a carbohydrate or a glycoconjugate by a remodeling reaction in the presence of a glycosidase which performs the remodeling reaction in an aqueous medium containing a water-soluble ketone and/or dioxane. Examples of the glycosidase include endoglycosidases such as Endo-A. Examples of the ketone include acetone.

Abstract: Neoglycoconjugates and new intermediates for the synthesis thereof are synthesized by use of Endo-.beta.-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) in a medium containing an organic solvent.

Abstract: Neoglycoconjugates and new intermediates for the synthesis thereof are synthesized by use of Endo-.beta.-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) in a medium containing an organic solvent.