Abstract: A method of enhancing the activity of lysosomal &agr;-Galactosidase A (&agr;-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: A system and a method of a three-dimensional color image display utilizing laser induced fluorescence (LIF) of nano-particles and molecules in a transparent medium are disclosed. In one preferred embodiment, a three-dimensional display volume contains three types (for red, green and blue color) of LIF nano-particles and/or molecules dispersed in a random, uniform fashion in a transparent, fluid like medium. In another preferred embodiment, a color image display system consists of at least two light sources each equipped with two-dimensional scanning hardware and a LIF display volume, a protective coating and at least two light sensors. The protective wavelength filtering coating blocks intense excitation light sources from harming image viewers while passing the LIF display light. The light sensors provide calibration and timing reference signals to maintain stable performance. A host of preferred fluorescence materials are also disclosed.

Abstract: This application provides methods of improving gene therapy by combining gene therapy with active site-specific chaperones (ASSCs). The ASSC increases the stability and efficiency of the protein encoded by the recombinant gene that is administered.

Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.

Abstract: A method of enhancing the activity of lysosomal &agr;-Galactosidase A (&agr;-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

Abstract: An audio jack assembly (1) includes an audio jack (2) and a flexible printed circuit board (PCB) (3). The audio jack includes an insulative housing (20) and a plurality of contacts received therein. Each contact has a soldering portion (22) extending out of the housing. The flexible PCB includes a plurality of solder pads (32) and a plurality of terminals (36) electrically connected with corresponding solder pads. The soldering portions of the contacts of the audio jack are soldered to corresponding solder pads. The terminals are disposed on an end portion (34) of the flexible PCB and extend rearwardly to be contacted with an interface in an electronic device.

Abstract: An electrical connector (100) has an insulative housing (8), a plurality of terminals (9) received in the housing and a metal shield (7). The housing has a body portion (81) and two side portions (82) formed respectively on lateral sides of the body portion. Each side portion has a passage (821) extending therethrough and a notch (822) in communication with the passage. The shield has two retentive tabs (731) respectively projecting through corresponding passages with free ends thereof received in corresponding notches of the housing. The terminals have vertical contacting sections (91), vertical connecting sections (93), horizontal retention sections (92) connecting the contacting sections with the connecting sections, and soldering sections (94) extending horizontally from the connecting sections.

Abstract: An electrical connector (1) includes an insulative housing (2) retaining a plurality of first contacts (3) and second contacts (4). The housing defines a row of upper passageways (28) for receiving the first contacts and a row of lower passageways (29) for receiving the second contacts. The housing forms a plurality of retaining poles (246, 273) thereon. The first contacts include apertures (373, 374) engaging with corresponding retaining poles. The retaining poles have free ends riveted on the first contacts for securely retaining the first contacts in the housing.

Abstract: An electrical connector (1) adapted to mate with a complementary connector (90) which has a tongue portion (91) with a plurality of conductive terminals (92) disposed thereon, includes an insulative housing (50) having a mating portion (53) protruding forwardly therefrom and a receiving cavity (55) defined therethrough, and a plurality of conductive contacts (60) received in the cavity of the housing. An upper wall (531) and a lower wall (532) form the mating portion, with the receiving cavity being defined therebetween. The contacts are positioned on the lower wall. A pair of engaging bars (551) protrudes from the upper wall into the receiving cavity. When the mating portion mates with the tongue portion, the engaging bars downwardly push the tongue portion to ensure a reliable connection between the conductive terminals and corresponding contacts.

Abstract: Method fore enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

Abstract: An electrical connector assembly (7) including an audio jack connector (1) and a DC jack connector (3), has a housing (10), a set of audio contacts (20) and two sets of powering contacts (30, 50). The housing has a plurality of retaining grooves (119, 120, 117, 118, 126, 127, 128, 129). The set of audio contacts has a plurality of audio contacts (21, 22, 24, 23, 25). The audio contacts have locating tabs (211, 221, 244, 231) and contact tabs (217, 226, 247, 237, 254). The set of powering contacts has a plurality of powering contacts (31, 32, 51, 53, 54) forming a first and second circuit loops. The powering contacts have a rigid pin (531) and contact tabs (516, 543). The rigid pin and the contact tabs are separately disposed.

Abstract: An electrical connector assembly (7) including an audio jack connector (1) and a DC jack connector (3), has a housing (10), a set of audio contacts (20) and two sets of powering contacts (30, 50). The housing has a plurality of retaining grooves (119, 120, 117, 118, 126, 127, 128, 129). The set of audio contacts has a plurality of audio contacts (21, 22, 24, 23, 25). The audio contacts have locating tabs (211, 221, 244, 231) and contact tabs (217, 226, 247, 237, 254). The set of powering contacts has a plurality of powering contacts (31, 32, 51, 53, 54) forming a first and second circuit loops. The powering contacts have a rigid pin (531) and contact tabs (516, 543). The rigid pin and the contact tabs are separately disposed.

Abstract: Method fore enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme Prefcrred compounds for use in the method are imino sugars and related compounds

Abstract: A displayable jewelry container includes a box, a cover, and a display base affixed at a bottom surface of the cover. The box has a pair of integral guiding track groove provided on two inner surfaces of two parallel side panels of the box respectively. The cover has two pairs of guiding pegs protruded on two outer surfaces of two parallel cover side panels and slidably inserted into the pair of integral guiding track groove respectively so as to slidably support the cover on the box, wherein when the cover is arranged to cover the top opening of the box, the display base is disposed inside the box and covered by the cover, wherein to open the box for displaying the product, flip a front side of the cover over to up side down the cover until the display base is placed on top.

Abstract: A displayable jewelry container includes a box, a cover, and a display base affixed at a bottom surface of the cover. The box has a pair of integral guiding track groove provided on two inner surfaces of two parallel side panels of the box respectively. The cover has two pairs of guiding pegs protruded on two outer surfaces of two parallel cover side panels and slidably inserted into the pair of integral guiding track groove respectively so as to slidably support the cover on the box, wherein when the cover is arranged to cover the top opening of the box, the display base is disposed inside the box and covered by the cover, wherein to open the box for displaying the product, flip a front side of the cover over to up side down the cover until the display base is placed on top.