Abstract: The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction.

Abstract: A method for quantitative analysis of a cavity at the top of a concrete-filled steel tube is disclosed. By substitution of the determined inner radius of the steel tube, the thickness of the steel tube wall and the propagation speed of ultrasonic waves in the steel tube and in the concrete, the propagation time of the ultrasonic wave between the top and the bottom of the concrete-filled steel tube enables calculation of the height of the cavity. The method can be used to quantify the cavity height at the top of the concrete-filled steel tube, with small relative errors and high accuracy.

Abstract: A rail apparatus, a laser apparatus, and a laser machining device are provided in the present disclosure. The rail apparatus includes a rail frame assembly and a mounting assembly. The rail frame assembly includes a rail frame and a guide shaft fixed to the rail frame. The mounting assembly includes a mounting base and a pulley. The pulley defines a sliding groove. The sliding groove is slidably connected with the guide shaft. The laser apparatus includes a base, a laser, and a focusing member. The laser is disposed on the base and is configured to emit a laser light. The focusing member is movably disposed on the base and has a focusing end. The laser apparatus is operable in a retracting state and an extending state. The laser machining device includes the rail apparatus and the laser apparatus.

Abstract: A ground-engaging track includes a track chain formed of standard links and at least one master link. The master link include a first half link and a second half link, clamped together by way of a forward bolt and a rearward bolt. Clamping surfaces of the first half link and the second half link form a first tooth set and a second tooth set, respectively, which may include a total of 2 or 3 full teeth and tooth roots, confined in distribution between a forward bolt hole and a rearward bolt hole.

Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.

Abstract: Compositions and methods are provided according to aspects of the present disclosure for inhibition of a pathogenic virus. According to particular aspects, compositions and methods of the present disclosure include degradation of pathogenic viral nucleic acids by interferon-stimulated gene 20-kDa protein (ISG20) and/or a variant thereof, administered to a cell and/or subject to inhibit a pathogenic viral infection of the cell and/or a subject. Compositions and methods are provided according to aspects of the present disclosure wherein providing the ISG20 protein, or a variant thereof, comprises administering a therapeutically effective amount of the ISG20 protein and/or variant, to a subject having, or at risk of having, a viral infection.

Abstract: A display panel driving method, a drive circuit thereof, and a display device. The method comprises: when determined that the picture to be displayed belongs to a high power consumption display picture, providing a touch control and display integrated circuit and power supply management circuit of the display panel with a second reference voltage that is amplified by a first reference voltage and that is provided by an external voltage source, and driving each pixel to ensure the normal display of the high power consumption display picture; and when determined that the picture to be displayed belongs to a low power consumption display picture, directly providing the first reference voltage to the touch control and display integrated circuit and power supply management circuit of the display panel, and driving each pixel within the display panel so as to ensure the normal display of the low power consumption picture.

Abstract: An automated testing method and apparatus relate to the technical field of software test. The automated testing method includes: configuring a common Software Development Kit (SDK) interface and a Basic SDK model, and receiving a to-be-tested script comprising control information data and an operation type by using the SDK interface; performing a standardization process on the control information data using the SDK basic model to obtain a standard data structure; and running the to-be-tested script according to the operation type, and positioning a to-be-tested control in the to-be-tested script according to the standard data structure.

Abstract: A display panel, a manufacturing method thereof and a display device are provided. The display panel includes a display area and a frame area surrounding the display area, and includes an array substrate and a color filter substrate. The color filter substrate includes a substrate, first support structures in the display area and second support structures in the frame area; each first support structure includes a first main support part in contact with the array substrate and a first auxiliary support part having a first gap with the array substrate; each second support structure includes a second main support part in contact with the array substrate and a second auxiliary support part having a second gap with the array substrate; and a thickness of the first auxiliary support part is greater than a thickness of the second auxiliary support part.

Abstract: A cartridge pin assembly in a track chain assembly includes a sleeve bearing having a flared end.

Abstract: The present disclosure is related to a display device and a circuit board (200). The display device comprises a light-emitting module (100), a circuit board (200) and a conductive structure (300). The surface of the light-emitting module (100) is provided with a conductive portion (101). The circuit board (200) is arranged on a back face (102) of the light-emitting module (100), and has a first surface (201) close to the light-emitting module (100). The first surface (201) of the circuit board (200) is provided with an exposed external conductive layer (210), and the external conductive layer (210) is electrically connected to a ground wire of the circuit board (200). The conductive structure (300) is located between the circuit board (200) and the light-emitting module (100), and makes the external conductive layer (210) electrically connect to the conductive portion (101).

Abstract: A ground-engaging track includes a track chain formed of standard links and at least one master link. The master link include a first half link and a second half link, clamped together by way of a forward bolt and a rearward bolt. Clamping surfaces of the first half link and the second half link form a first tooth set and a second tooth set, respectively, which may include a total of 2 or 3 full teeth and tooth roots, confined in distribution between a forward bolt hole and a rearward bolt hole.

Abstract: Systems and methods for automatic restocking different items in retail store environments having POS locations for the items are disclosed. The method includes, for a first item of the different items, storing at least one first item parameter uniquely identifying the first item. The method includes determining, based on the at least one first item parameter, a first autonomous movement control scheme for manipulation of the first item by a robotic arm. The method includes executing, by the robotic arm, the first control scheme, the executing including shelving the first item on the shelf. The method includes evaluating, by a processor or a user of the robotic arm, the executing for the first item according to at least one predetermined first performance criteria. The method includes determining and storing, based on the evaluating, an updated first control scheme for subsequent executing by the robotic arm for the first item.

Abstract: A display panel includes an array substrate and an opposite substrate that are disposed opposite to each other, a liquid crystal layer disposed between the array substrate and the opposite substrate, and a plurality of spacers disposed on a side of the opposite substrate proximate to the array substrate. The array substrate includes a substrate and at least one metal platform disposed on a side of the substrate proximate to the opposite substrate. At least one spacer of the plurality of spacers is disposed opposite to the metal platform; and an orthographic projection of an end, proximate to the substrate, of the spacer on the substrate is located within an orthographic projection of the metal platform on the substrate.

Abstract: An automatic testing method and apparatus are provided. In the method, a Software Development Kit (SDK) interface is configured and User Interface (UI) rendering data which includes a plurality of UI controls is obtained through the SDK interface. The UI rendering data is a standardized data structure processed through the SDK interface. An operation event of a user on the UI rendering data is received, and a simulation operation of the user on the UI rendering data on a terminal device is determined according to the operation event. Position information of a UI control corresponding to the simulation operation is determined, and a UI automated test script is determined according to the position information and the simulation operation. The UI automated test script is run and debugged using an automated test framework.

Abstract: A cartridge pin assembly in a track chain assembly includes a sleeve bearing having a flared end.

Abstract: A display panel driving method, a drive circuit thereof, and a display device. The method comprises: when determined that the picture to be displayed belongs to a high power consumption display picture, providing a touch control and display integrated circuit and power supply management circuit of the display panel with a second reference voltage that is amplified by a first reference voltage and that is provided by an external voltage source, and driving each pixel to ensure the normal display of the high power consumption display picture; and when determined that the picture to be displayed belongs to a low power consumption display picture, directly providing the first reference voltage to the touch control and display integrated circuit and power supply management circuit of the display panel, and driving each pixel within the display panel so as to ensure the normal display of the low power consumption picture.

Abstract: A system and method for collecting data regarding operation of a robot using, at least in part, responses from a first operation model to an input of sensed data from a plurality of sensors. The collected data can be used to optimize the first operation model to generate a second operation model. While the first operation model is being optimized, a train data-driven model that utilizes an end-to-end learning approach can be generated that is based, at least in part, on the collected data. Both the second operation model and the train data-driven model can be evaluated, and, based on such evaluation, a determination can be made as to whether the train data-driven model is reliable. Moreover, based on a comparison of the models, one of the second operation model and the train data-driven model can be selected for validation, and if validated, used in the operation of the robot.

Abstract: A system and method that automatically resolves conflicts among sensor information in a sensor fusion robot system. Such methods can accommodate converging ambiguous and divergent sensor information in a manner that can allow continued, and relatively accurate, robotic operations. The processes can include handling sensor conflict via sensor prioritization, including, but not limited, prioritization based on the particular stage or segment of the assembly operation when the conflict occurs, overriding sensor data that exceeds a threshold value, and/or prioritization based on evaluations of recent sensor performance, predictions, system configuration, and/or historical information. The processes can include responding to sensor conflicts through comparisons of the accuracy of workpiece location predictions from different sensors during different assembly stages in connection with arriving at a determination of which sensor(s) is providing accurate and reliable predictions.