Patents by Inventor Jide Xu

Jide Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 11951188
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: April 9, 2024
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20240067650
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 29, 2024
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Macrocycles
    Patent number: 11691997
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 4, 2023
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 11603371
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 14, 2023
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • Di-macrocycles
    Patent number: 11453652
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: September 27, 2022
    Assignee: LUMIPHORE, INC.
    Inventors: Darren Magda, Jide Xu, Nathaniel G. Butlin
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20200405887
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 31, 2020
    Inventors: David TATUM, Jide XU, Darren MAGDA, Nathaniel BUTLIN
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20200062757
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 25, 2019
    Publication date: February 27, 2020
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • RADIOPHARMACEUTICAL COMPLEXES
    Publication number: 20200024234
    Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Application
    Filed: January 7, 2019
    Publication date: January 23, 2020
    Inventors: Jide Xu, Nathaniel Butlin, Darren Magda
  • Functionalized linear ligands and complexes thereof
    Patent number: 10434186
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: October 8, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Macrocyclic HOPO chelators
    Patent number: 10352938
    Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: July 16, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Kenneth N. Raymond, Jide Xu, Anthony D'Aleo
  • Macrocycles
    Patent number: 10273256
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: April 30, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: Nathaniel G. Butlin, Darren Magda, Jide Xu
  • Macrocyclic ligands with pendant chelating moieties and complexes thereof
    Patent number: 10239878
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: March 26, 2019
    Assignee: LUMIPHORE, INC.
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • MACROCYCLES
    Publication number: 20180298040
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: June 22, 2018
    Publication date: October 18, 2018
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF
    Publication number: 20180194766
    Abstract: The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Inventors: David Tatum, Jide Xu, Darren Magda, Nathaniel Butlin
  • FUNCTIONALIZED LINEAR LIGANDS AND COMPLEXES THEREOF
    Publication number: 20170360956
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: December 21, 2015
    Publication date: December 21, 2017
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • MACROCYCLES
    Publication number: 20170183365
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: April 1, 2015
    Publication date: June 29, 2017
    Inventors: Nathaniel G. BUTLIN, Darren MAGDA, Jide XU
  • Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
    Patent number: 9556122
    Abstract: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: January 31, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kenneth N. Raymond, Jide Xu, Evan G. Moore, Eric J. Werner
  • MACROCYCLIC HOPO CHELATORS
    Publication number: 20160320399
    Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.
    Type: Application
    Filed: February 25, 2016
    Publication date: November 3, 2016
    Inventors: Nathaniel G. BUTLIN, Kenneth N. RAYMOND, Jide XU, Anthony D'ALEO
  • Macrocycles
    Patent number: 9439984
    Abstract: The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 13, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kenneth N. Raymond, Jide Xu, Tiffany A. Pham
  • DI-MACROCYCLES
    Publication number: 20160221971
    Abstract: The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
    Type: Application
    Filed: November 15, 2013
    Publication date: August 4, 2016
    Applicant: LUMIPHORE, INC.
    Inventors: Darren Magda, Jide Xu, Nathaniel G. Butlin