Patents by Inventor Jide Xu
Jide Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9273059Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.Type: GrantFiled: August 24, 2010Date of Patent: March 1, 2016Assignee: LUMIPHORE, INC.Inventors: Nathaniel G. Butlin, Kenneth N. Raymond, Jide Xu, Anthony D'Aleo
-
Publication number: 20150157746Abstract: The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.Type: ApplicationFiled: March 14, 2013Publication date: June 11, 2015Inventors: Kenneth N. Raymond, Jide Xu, Tiffany A. Pham
-
Patent number: 8729258Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: GrantFiled: April 30, 2012Date of Patent: May 20, 2014Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Todd M. Corneillie, Jide Xu
-
Publication number: 20140039169Abstract: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.Type: ApplicationFiled: October 8, 2013Publication date: February 6, 2014Inventors: Kenneth N. RAYMOND, Jide Xu, Evan G. Moore, Eric J. Werner
-
Patent number: 8557601Abstract: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.Type: GrantFiled: July 10, 2007Date of Patent: October 15, 2013Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Jide Xu, Evan G. Moore, Eric J. Werner
-
Patent number: 8551453Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: December 29, 2004Date of Patent: October 8, 2013Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Jide Xu
-
Patent number: 8507199Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: GrantFiled: January 25, 2008Date of Patent: August 13, 2013Assignee: Lumiphore, Inc.Inventors: Nathaniel G. Butlin, Todd M. Corneillie, Jide Xu
-
Publication number: 20120329174Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: ApplicationFiled: April 30, 2012Publication date: December 27, 2012Applicant: The Regents of the University of CaliforniaInventors: Kenneth N. RAYMOND, Tood M. CORNEILLIE, Jide XU
-
Publication number: 20120214253Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.Type: ApplicationFiled: August 24, 2010Publication date: August 23, 2012Applicant: LUMIPHORE, INC.Inventors: Nathaniel G. Butlin, Kenneth N. Raymond, Jide Xu, Anthony D'Aleo
-
Patent number: 8173800Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: GrantFiled: August 15, 2007Date of Patent: May 8, 2012Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Todd M. Corneillie, Jide Xu
-
Publication number: 20110189088Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.Type: ApplicationFiled: December 23, 2010Publication date: August 4, 2011Applicant: Lumiphore, Inc.Inventors: Jide Xu, Nathaniel G. Butlin, Darren Magda
-
Publication number: 20100167289Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: ApplicationFiled: January 25, 2008Publication date: July 1, 2010Inventors: Nathaniel G. Butlin, Todd M. Corneillie, Jide Xu
-
Publication number: 20100015725Abstract: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.Type: ApplicationFiled: July 10, 2007Publication date: January 21, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kenneth N. Raymond, Jide Xu, Evan G. Moore, Eric J. Werner
-
Publication number: 20090036537Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: ApplicationFiled: December 29, 2004Publication date: February 5, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kenneth N. Raymond, Stephane Petoud, Jide Xu
-
Publication number: 20090023928Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: ApplicationFiled: September 1, 2008Publication date: January 22, 2009Applicant: The Regents of the Univeristy of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
-
Publication number: 20080293155Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: ApplicationFiled: June 11, 2008Publication date: November 27, 2008Applicant: The Regents of the Univeristy of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
-
Patent number: 7442558Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: June 14, 2004Date of Patent: October 28, 2008Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
-
Publication number: 20080213917Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: ApplicationFiled: August 15, 2007Publication date: September 4, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Kenneth N. Raymond, Todd M. Corneillie, Jide Xu
-
Publication number: 20080213780Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.Type: ApplicationFiled: January 25, 2008Publication date: September 4, 2008Applicant: Lumiphore, Inc.Inventors: Nathaniel G. Butlin, Todd M. Corneillie, Jide Xu
-
Patent number: 7404912Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: February 6, 2006Date of Patent: July 29, 2008Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu