Patents by Inventor Jide Xu

Jide Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salicylamide-lanthanide complexes for use as luminescent markers
    Publication number: 20060286567
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Application
    Filed: February 6, 2006
    Publication date: December 21, 2006
    Applicants: The regents of the University of California, Regents of UC Licensing Associate Office Technology Licensing
    Inventors: Kenneth Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • Salicylamide-lanthanide complexes for use as luminescent markers
    Patent number: 7018850
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: March 28, 2006
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • Phthalamide-lanthanide complexes for use as luminescent markers
    Publication number: 20050058604
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Application
    Filed: June 14, 2004
    Publication date: March 17, 2005
    Inventors: Kenneth Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • Phthalamide-lanthanide complexes for use as luminescent markers
    Patent number: 6864103
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: March 8, 2005
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth M. Cohen, Jide Xu
  • Salicylamide-lanthanide complexes for use as luminescent markers
    Publication number: 20030027189
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Application
    Filed: June 7, 2002
    Publication date: February 6, 2003
    Applicant: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • Phthalamide lanthanide complexes for use as luminescent markers
    Patent number: 6515113
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: February 4, 2003
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth M. Cohen, Jide Xu
  • Phthalamide lanthanide complexes for use as luminescent markers
    Publication number: 20020188111
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Application
    Filed: February 18, 2000
    Publication date: December 12, 2002
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • Phthalamide-lanthanide complexes for use as luminescent markers
    Publication number: 20020128451
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Application
    Filed: November 14, 2001
    Publication date: September 12, 2002
    Applicant: Regents of UC Licensing Associate Office of Technology Licensing
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth M. Cohen, Jide Xu
  • Salicylamide-lanthanide complexes for use as luminescent markers
    Patent number: 6406297
    Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: June 18, 2002
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
  • 3-hydroxy-2(1H)-pyridinone chelating agents
    Patent number: 5892029
    Abstract: Disclosed is a series of improved chelating agents and the chelates formed from these agents, which are highly effective upon both injection and oral administration. Several of the most effective are of low toxicity. These chelating agents incorporate within their structure 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy group of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity, as well as the chemical stability towards oxidation and reduction, of the hydroxypyridinones. In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with the adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provide a certain degree of lipophilicity to the 3,2-HOPO, increasing oral activity.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: April 6, 1999
    Assignee: The Regents of the University of California
    Inventors: Kenneth Raymond, Jide Xu
  • 3-hydroxy-2(1H)-pyridinone chelating agents
    Patent number: 5624901
    Abstract: Disclosed is a series of improved metal chelating agents, which are highly effective upon both injection and oral administration; several of the most effective are of low toxicity. These chelating agents incorporate within their structure 1-hydroxy-2-pyridinone (1,2-HOPO) and 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy or oxo groups of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity of the hydroxypyridinones. In the metal complexes of said chelating agents, the amide protons form very strong hydrogen bonds with its adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provides a certain degree of lipophilicity to said 3,2-HOPO, increasing oral activity.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: April 29, 1997
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Jide Xu