Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

Abstract: Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.

Abstract: Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

Abstract: A method for routing packets sent from a user to the internet is provided for systems in which the user is connected to a private network. The method includes: extracting a source network address from the packet; using said source network address to retrieve a user profile for the user; examining said user profile to determine whether to route the packet through the private network or to route the packet directly to the Internet; and routing said packet according to said profile. This allows a user or network provider to choose whether to route packets destined for the Internet directly to the Internet rather than through the private network, thus preventing excessive network traffic on the private network.

Abstract: Certain bits of a packet, such as bits in the IP header of an IP packet, are used to designate the type of service or Quality of Service (QoS) level to be afforded to the packet as it passes through a data communications network. A user entitled to a certain QoS level logs into a service selection gateway SSG. The SSG queries an authentication, authorization and accounting (AAA) server in response to a log-in attempt by the user. Upon authorization, the AAA server returns an access accept signal in addition to an indication from the user's service profile (user profile) as to the QoS level to be afforded the user. While the user is logged in, all packets are routed through the SSG. The SSG sets the certain bits of the packet in accordance with the user's assigned QoS level so that as the packets are routed through the data communications network, they are consistently afforded the assigned Quality of Service level.

Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.

Abstract: A method and apparatus for providing management and maintenance to a node within a data communications network and to the composite data communications network. A network management application is started on a host which may be located at a network operation center. The management application is in communication with network nodes and services through adapters. A master daemon located at a node is activated. The master daemon starts a control adapter running on the node and if the control adapter fails the master daemon restarts the control adapter. The control adapter is capable of starting and stopping all services running on the node. Signals are communicated between the management application, the node and the services by way of adapters. Signaling provides for the exchange of useful event data related to the nodes and services running on the nodes.

Abstract: There are provided compounds of the formula wherein R1, R2, R3, X, Y, Q, Ring A and Ring B are as described. The compounds exhibit activity as anticancer agents.

Abstract: The present invention relates to compounds of the formula medicaments containing them and the use of these compounds as pharmaceutically active agents. The compounds exhibit activity as Raf kinase inhibitors and therefore may be useful for the treatment of diseases mediated by said kinases, especially as anticancer agents.

Abstract: A method and apparatus for resolving where to forward DNS (domain name service) requests for a user simultaneously logged into more than one service existing on a data communications network utilizes an active service list (ASL) to keep track of the services that the user is currently logged into. The active service list includes a list of services sorted in a particular order based on information about the service and sometimes the order in which the user logged into the services. Each service has a profile that defines, among other things, the IP Address space for the service and a Domain attribute. To determine the appropriate service and, therefore, the appropriate DNS server for a DNS request, the QName from the DNS request is compared to the configured Domain attribute(s) for each service in the order of the ASL. If a match is found, then the DNS request packet is modified to re-direct the DNS request to the DNS server configured for the matched service.

Abstract: Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.

Abstract: Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

Abstract: The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

Abstract: Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.

Abstract: Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

Abstract: A gateway is provided which routes a packet sent from a user to a connected network utilizing a per-user routing table. This is accomplished by extracting a source address from the packet; finding a per-user routing table corresponding to the source address, the per-user routing table containing entries corresponding to one or more currently accessible networks for the user and the range of network addresses corresponding to the currently accessible networks; extracting a destination address from the packet; seeking an entry in the matching per-user routing table with a range of network addresses containing the destination address; routing the packet to a matching network if the destination address is contained within one of the ranges of network addresses for the currently accessible networks; and routing the packet to a default network if the destination address is not contained within one of the ranges of network addresses for the currently accessible networks.

Abstract: A method for providing single step log-on access for a subscriber to a computer network. The computer network is differentiated into public and private areas. Secure access to the private areas is provided by a Service Selection Gateway (SSG) Server, introduced between a conventional Network Access Server (NAS) and an Authentication Authorization and Accounting (AAA) Server. The SSG Server intercepts and manipulates packets of data exchanged between the NAS and the AAA Server to obtain all the information it needs to automatically log the user on when the user logs on to the NAS. An authorized user is thus spared the task of having to re-enter username and password data or launch a separate application in order to gain secure access to private areas of the network.

Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.

Abstract: Certain bits of a packet, such as bits in the IP header of an IP packet, are used to designate the type of service or Quality of Service (QoS) level to be afforded to the packet as it passes through a data communications network. A user entitled to a certain QoS level logs into a service selection gateway SSG. The SSG queries an authentication, authorization and accounting (AAA) server in response to a log-in attempt by the user. Upon authorization, the AAA server returns an access accept signal in addition to an indication from the user's service profile (user profile) as to the QoS level to be afforded the user. While the user is logged in, all packets are routed through the SSG. The SSG sets the certain bits of the packet in accordance with the user's assigned QoS level so that as the packets are routed through the data communications network, they are consistently afforded the assigned Quality of Service level.

Abstract: Certain bits of a packet, such as bits in the IP header of an IP packet, are used to designate the type of service or Quality of Service (QoS) level to be afforded to the packet as it passes through a data communications network A user entitled to a certain QoS level logs into a service selection gateway SSG. The SSG queries an authentication, authorization and accounting (AAA) server in response to a log-in attempt by the user. Upon authorization, the AAA server returns an access accept signal in addition to an indication from the user's service profile (user profile) as to the QoS level to be afforded the user. While the user is logged in, all packets are routed through the SSG. The SSG sets the certain bits of the packet in accordance with the user's assigned QoS level so that as the packets are routed through the data communications network, they are consistently afforded the assigned Quality of Service level.