Abstract: A traditional Chinese medicine compound composition with effect of improving male sexual function and its application are disclosed. The disclosure prepares the traditional Chinese medicine compound composition by compounding Semen Allii Tuberosi with Radix Morindae Officinalis, Epimedii Folium, Cistanche deserticola Ma and Semen Cuscutae. The traditional Chinese medicine compound composition has a good effect on improving the sexual function of kidney Yang deficiency model mice. While improving sexual function, it can improve the abundance of spermatogenic cells in testicular seminiferous tubules, ensure that spermatogenic cells can continuously produce new sperm, and improve the number and morphology of sperm in the lumen. Moreover, the disclosed traditional Chinese medicine compound composition can be used as a raw material of dietary supplement or health food for the male population with low sexual function and easy fatigue.

Abstract: The present disclosure provides compounds having Stimulator of Interferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are a compound of formula (I) or formula (II): wherein the substituents are as defined herein. Ring A is a bicyclic fully aromatic or partially reduced heteroaryl ring system comprising 3, 4, or 5 N atoms, substituted with 0, 1, 2, 3,or 4 substituents as defined herein. Compounds for practice of a method of the present disclosure can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immune-checkpoint targeting drug.

Abstract: A constant power backup power supply for LED lighting fixtures is disclosed. The power supply includes a storage battery that is charged while an AC power source is in an ON condition. When AC power transitions to an OFF condition, a capacitor bank charged by the battery supplies current to the primary side of a flyback converter operating in discontinuous conduction mode. The secondary side of the flyback converter supplies constant output power to the LED lighting fixture for an arbitrary output voltage within a predetermined range.

Abstract: Systems and methods for inspecting particles in a liquid beneficial agent are provided.

Abstract: A thin-film composite polyamide reverse osmosis membrane with anti-bacterial and anti-biofouling effects and a preparation method thereof are disclosed. The preparation method includes: dissolving a highly water-stable metal organic framework CuBTTri in an n-hexane solution containing trimesoyl chloride by ultrasonic wave, immersing a polyethersulfone ultrafiltration membrane in an aqueous solution of m-phenylene diamine and taking out, and then immersing the ultrafiltration membrane in the trimesoyl chloride-n-hexane solution containing the aforementioned metal organic framework for reaction and modification, so as to obtain the thin-film composite polyamide reverse osmosis membrane. The resulting composite reverse osmosis membrane integrated with the anti-bacterial metal organic framework CuBTTri has a high reverse osmosis membrane permeability and possesses greatly improved and persistent anti-bacterial and anti-biofouling properties.

Abstract: The present disclosure relates to a display device, a touch panel and a manufacturing method thereof. The touch panel includes a substrate and a touch layer. The touch layer is disposed on a side of the substrate, and includes a first touch area and a border area surrounding the first touch area. The border area includes at least one second touch area, the second touch area includes a plurality of button portions. The button portions include at least one mutual-capacitance button portion, and the mutual-capacitance button portion includes a first touch electrode, a second touch electrode, and a dummy electrode disposed in a same layer, and there is a gap between the first touch electrode and the second touch electrode. The dummy electrode is disposed in the gap between the first touch electrode and the second touch electrode, and separated from the first touch electrode and the second touch electrode.

Abstract: The disclosure relates to an artificial intelligence-based difficult airway evaluation method and device. The method includes the following steps: acquiring facial images of various postures; constructing a feature extraction network based on facial recognition, and extracting feature information of the facial images through the trained feature extraction network; and constructing a difficult airway classifier based on a machine learning algorithm, and performing difficult airway severity scoring on the extracted feature information of the facial images through the trained difficult airway classifier to obtain an evaluation result of a difficult airway. According to the present disclosure, early warning can be accurately provided for difficult airways in clinical anesthesia.

Abstract: The present disclosure relates to a light emitting substrate, a display device and a fabricating method. The substrate includes: a base substrate, and an electrode layer, a first insulating layer, a first wiring layer, a second insulating layer, a second wiring layer and light emitting elements sequentially located on a side of the base substrate; the electrode layer includes: a plurality of first touch control electrodes extending along a first direction; the first wiring layer includes: a plurality of driving signal wires extending along a second direction and configured to drive the light emitting elements to emit light, and a plurality of second touch control electrodes extending along the second direction, where the second touch control electrodes are insulated from the first touch control electrodes, and the second direction intersects with the first direction; and the second wiring layer includes: connection signal wires configured to connect different light emitting elements.

Abstract: A display device and a fabrication method thereof are disclosed. A display device, including: a display panel and a cover plate provided opposite to each other; and a support layer, provided between the display panel and the cover plate, the support layer being configured to support the display panel and the cover plate, so that a gap is provided between the display panel and cover plate; the support layer comprising a plurality of first support portions; and the plurality of first support portions are dispersedly arranged and spaced apart from each other.

Abstract: The presently disclosed subject matter relates to feed additive formulations for fish. The disclosed formulations may comprise an isolated xylanase enzyme and a B. licheniformis strain PWD-1. The feed additive formulations may further include B. amyloliquefaciens strain Ba-BPD1. The disclosed formulations are useful for addition to feeds for fish to synergistically improve the performance of the fish.

Abstract: This invention relates to a device for mapping and ablating the renal nerves distributed on the renal artery, said device comprising a guide catheter, a mapping-ablation catheter, a handle and a connector. The guide catheter has at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter is housed in one of the lumens of the guide catheter and its distal end has one or more electrodes and one or more detecting devices. The distal end of the mapping-ablation catheter is curved, rotatable, and can be extended out of or retracted into the guide catheter. The handle connects the guide catheter and mapping-ablation catheter, and comprises one or more controlling components for controlling the movement of the guide catheter and mapping-ablation catheter. The connector is designed to supply energy to the electrodes.

Abstract: The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors inpatients afflicted therewith. The compounds are of formula (IA), formula (I), and formula (II): wherein the various substituents are as defined herein. Ring A is a 5- or 6-membered heteroaryl comprising 1, 2, or 3 N atoms, unsubstituted or substituted with 1, 2, or 3 groups as defined herein. Compounds for practice of a method of the invention can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immunecheckpoint targeting drug.

Abstract: The present invention provides indazole derivatives or their pharmaceutically acceptable salts or stereoisomers having the structure shown in formula (I), and their pharmaceutical compositions and applications thereof. Such compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of tropomyosin receptor kinase (TRK) protein kinase and can inhibit the proliferation, migration and invasion of a variety of tumor cells.

Abstract: The present invention discloses a method for preparing a drug-loaded silk fibroin nanocapsule, and a prepared drug-loaded silk fibroin nanocapsule. The method comprises: performing a coating treatment of applying alternating layers of silk fibroin and 3-aminopropyl triethoxysilane on functionally modified polystyrene microspheres, to ultimately obtain a multi-layer-structured coated polystyrene composite with a negative or positive potential, and finally removing the functionally modified polystyrene template with a template-removing reagent, to obtain a drug-loaded silk fibroin nanocapsule. The functionally modified polystyrene microspheres are positive potential microspheres, and silk fibroin is used for the first coating. In the case of negative potential microspheres, 3-aminopropyl triethoxysilane is used for the first treatment. The process is simple and has wide applicability.

Abstract: Disclosed is a method for constructing fluorescent Bombyx Mori silkworm silk irradiated by near-infrared light and its products, comprising: (1) preparing upconversion nanoparticles, and performing surface modification with concanavalin to obtain modified upconversion nanoparticles; (2) uniformly dispersing the modified upconversion nanoparticles in water to formulate an aqueous solution of the upconversion nanoparticles, (3) picking mature mulberry leaves, immersing the mulberry leaves in the aqueous solution system of the nanoparticles, leaching water, and naturally drying the mulberry leaves; (4) after silkworms have grown for a set time, feeding the treated mulberry leaves to the silkworms until the silkworms spin silk cocoons; and (5) collecting the silk, so as to obtain mulberry silk that fluoresces under near-infrared light.

Abstract: An organic wastewater treatment method based on a multi-element co-doping TiO2 nano photocatalytic material includes preparing a sulfur-titanium dioxide mixture, hydrothermally reacting the sulfur-titanium dioxide mixture with copper chloride, ammonia, strong alkali, a transition metal salt and the like, reacting the resulting reaction product with hydrofluoric acid, then performing temperature programming thermal treatment in air to obtain the multi-element co-doping TiO2 nano photocatalytic material, and then treating organic wastewater with the multi-element co-doping TiO2 nano photocatalytic material under the irradiation of visible light.

Abstract: This invention provides methods for mapping and ablating renal nerves to treat disease caused by systemic renal nerve hyperactivity, e.g. hypertension, heart failure, renal failure and diabetes. Also provided are catheters for performing the mapping and ablating functions.

Abstract: A light emitting substrate, a light emitting motherboard, a method for obtaining a light emitting substrate, and a displaying device. The light emitting substrate comprises a substrate and multiple light emitting units, wherein the substrate is provided with a light emitting region and a bind region located on one side of the light emitting region; each light emitting unit comprises a light zone provided with at least one light emitting diode and a drive circuit provided with multiple pins, and the multiple light emitting units are arranged on the substrate in an array; a direction pointing from the light emitting region to the bind region is a first direction; and in the first direction, the drive circuit of at least one light emitting unit in the last row of the light emitting units is connected to an address line.

Abstract: A backplane, a backlight source, an illumination device and a displaying device. The backplane comprises a substrate; a first metal trace layer disposed on one surface of the substrate; an insulating layer disposed on a side, away from the substrate, of the first metal trace layer; a second metal trace layer disposed on a side, away from the substrate, of the insulating layer, an overlapping area existing between an orthographic projection of the second metal trace layer on the substrate and an orthographic projection of the first metal trace layer on the substrate; and a barrier layer disposed between the first metal trace layer and the second metal trace layer, an orthographic projection of the barrier layer on the substrate covering the overlapping area, and the barrier layer being used for preventing metals in the first metal trace layer and the second metal trace layer from growing towards each other.

Abstract: The present disclosure relates to a benzamide compound as shown in Formula I, an insecticidal comprising same, and a use of the compound as an insecticide in the fields of agriculture, forestry and health.