Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

Abstract: The invention provides a semiconductor device and a lateral diffused metal-oxide-semiconductor transistor. The semiconductor device includes a substrate having a first conductive type. A gate is disposed on the substrate. A source doped region is formed in the substrate, neighboring with a first side of the gate, wherein the source doped region has a second conductive type different from the first conductive type. A drain doped region is formed in the substrate, neighboring with a second side opposite to the first side of the gate. The drain doped region is constructed by a plurality of first doped regions with the first conductive type and a plurality of second doped regions with the second conductive type, wherein the first doped regions and the second doped regions are alternatively arranged.

Abstract: A self-lubricated actuator for a rotor blade flap of a helicopter having a housing; a motor having a shaft disposed in a bearing is provided. The actuator further has an output rod and a mechanism operatively associated with the motor and the output rod to transmit movement from the motor to the output rod. The housing includes a lubrication medium capable of substantially immersing the bearing, the motor shaft and the mechanism during operation.

Abstract: Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

Abstract: Various devices and methods for accessing and preparing treatment sites within the intervertebral disc space for subsequent negligible-incision surgical (NIS) or percutaneous procedures to treat disc degeneration and disc related back pain are disclosed. Also disclosed is a method for performing a percutaneous spine procedure including preparing a treatment site within the intervertebral disc space for subsequent delivery of a biomaterial to treat disc degeneration and disc related back pain.

Abstract: A self-lubricated actuator for a rotor blade flap of a helicopter having a housing; a motor having a shaft disposed in a bearing is provided. The actuator further has an output rod and a mechanism operatively associated with the motor and the output rod to transmit movement from the motor to the output rod. The housing includes a lubrication medium capable of substantially immersing the bearing, the motor shaft and the mechanism during operation.

Abstract: A device for controlling the pitch of a helicopter's rotor blade, the device having a BLDC motor based actuator; and at least one control surface operatively connected to the BLDC motor based actuator. The actuator and the control surface are preferably fully integrated into the interior profile of the rotor blade and are capable of controlling the PFC of the helicopter and improving HHC during operation by reducing noise and vibration. The motor is preferably a high power density motor incorporating rare earth permanent magnets connected to a roller/ball screw or planetary gear set to provide the right combination of force/torque, stroke and frequency.

Abstract: An architecture and methodology of redirection for dynamic new URL Links uses a first server device to get information flow content from a second server device. By inserting an application into the information flow content retrieved from the second server device, the first server device replaces the web objects, which may generate dynamic new URL links, with the redirect functions in the code and sends the content to the browser. The browser will execute the code automatically. Whenever the browser generates new dynamic new URL links, it would call the provided redirect functions, and thus redirect them and retrace back to the first server device.

Abstract: An auto-pumping unit for a bag-valve-mask resuscitator includes a housing, a pressure device, and driving mechanism. The housing has a receiving space for accommodating a bag of the bag-valve-mask, and a baffle mounted at a side of the receiving space. The pressure device is movably mounted at the other side of the receiving space opposite to the baffle. The driving mechanism is mounted in the housing and controlled to drive the pressure device to move close to or away from the baffle to compress or release the bag at a predetermined speed.