Abstract: The compositions and methods described herein are related to the identification of disease related genes, the expression of which involves a fraction of transcripts with a retained intron, comprising antisense oligonucleotides (ASO) compositions and methods that target genes which meet two criteria: the genes have a fraction of transcripts that retains an intron, and haploinsufficiency of the gene is associated with disease.

Abstract: Disclosed is an electronic device for predicting sarcopenia, which includes a memory and a processor connected with the memory to execute instructions included in the memory. The processor extracts a first result value as output data for a first machine learning model by using an eye image of a subject as input data for the first machine learning model and determines whether sarcopenia of the subject occurs based on the first result value. The first result value includes an MRD1 value of the subject corresponding to the eye image, an upper eyelid edge location change value, an eye closing speed value, and an eye opening speed value.

Abstract: A method of predicting the anterior chamber angle of the eye of a surgical candidate for lens implantation according to an embodiment of the present invention includes obtaining input data including a lens size, obtaining a predicted postoperative anterior chamber angle based on a learning model using the input data. The learning model may be trained based on the lens size and the measured postoperative anterior chamber angle of a plurality of patients who have undergone the lens implantation in the past.

Abstract: An electronic device for predicting myopia regression, which includes a memory and a processor connected with the memory to execute instructions included in the memory. The processor collects first target data of a subject and second target data of the subject, extracts a first result value as output data for a first machine learning model by using the first target data as input data for the first machine learning model, and determines whether there is a possibility of myopia regression of the subject based on the first result value.

Abstract: The present invention relates to a method for recommending a vision correction surgery, and the method according to one aspect of the present invention comprises: obtaining an examination data of a subject; predicting whether the vision correction surgery is suitable for the subject from the examination data; when the vision correction surgery is suitable for the subject, predicting whether the vision correction surgery using a laser is available for the subject from the examination data; when the vision correction surgery using the laser is available for the subject, calculating corneal shape factor prediction values of the subject after a standard vision correction surgery and a custom vision correction surgery from the examination data; and when the vision correction surgery using the laser is available for the subject, suggesting a vision correction surgery corresponding to the subject from the examination data.

Abstract: The present invention provides antisense oligonucleotides for the treatment of various T-type calcium channel ?1G subunit-related disorders, and more specifically, antisense oligonucleotides for inhibiting expression of the gene encoding Cav3.1, targeting SEQ ID NO: 1, for the treatment of various neuropsychiatric disorders, including Parkinson's disease, epilepsy, essential tremor, depression, anxiety disorders, and unconsciousness.

Abstract: Disclosed is a blowing unit of an air conditioner for a vehicle, having a two-layer structure and capable of effectively suppressing a flow of air flowing backward around a scroll bell mouth. In a blowing unit of an air conditioner for a vehicle, having a scroll case in which a first flow path and a second flow path are partitioned so as to separate inside and outdoor air to be sucked, the scroll case has a partition wall for separating a suction part of the first flow path and a suction part of the second flow path, and the partition wall has an air backflow prevention part for preventing air flowing into one of the first flow path or the second flow path from flowing backward into the other.

Abstract: Disclosed is a blowing unit of an air conditioner for a vehicle, having a two-layer structure and capable of effectively suppressing a flow of air flowing backward around a scroll bell mouth. In a blowing unit of an air conditioner for a vehicle, having a scroll case in which a first flow path and a second flow path are partitioned so as to separate inside and outdoor air to be sucked, the scroll case has a partition wall for separating a suction part of the first flow path and a suction part of the second flow path, and the partition wall has an air backflow prevention part for preventing air flowing into one of the first flow path or the second flow path from flowing backward into the other.

Abstract: A method for determining a lens and apparatus using the method are disclosed. According to an embodiment, a method for determining a lens to be inserted into an eyeball during lens implant surgery using machine learning may be provided, the method comprising: obtaining a plurality of examination data of a person to be operated on; and determining a size of a lens to be inserted into an eyeball of the person among a plurality of lens sizes by inputting the obtained plurality of examination data of the person to a lens determination model, wherein the lens determination model is different from a formula for determining a lens to be inserted into an eyeball during lens implant surgery, and is trained based on examination data of patients who have had lens implant surgery in the past and size information of lenses inserted into eyeballs of the patients.

Abstract: A method for determining a lens and apparatus using the method are disclosed. According to an embodiment, a method for determining a lens to be inserted into an eyeball during lens implant surgery using machine learning may be provided, the method comprising: obtaining a plurality of examination data of a person to be operated on; and determining a size of a lens to be inserted into an eyeball of the person among a plurality of lens sizes by inputting the obtained plurality of examination data of the person to a lens determination model, wherein the lens determination model is different from a formula for determining a lens to be inserted into an eyeball during lens implant surgery, and is trained based on examination data of patients who have had lens implant surgery in the past and size information of lenses inserted into eyeballs of the patients.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: The present invention relates to a method for recommending a vision correction surgery, and the method according to one aspect of the present invention comprises: obtaining an examination data of a subject; predicting whether the vision correction surgery is suitable for the subject from the examination data; when the vision correction surgery is suitable for the subject, predicting whether the vision correction surgery using a laser is available for the subject from the examination data; when the vision correction surgery using the laser is available for the subject, calculating corneal shape factor prediction values of the subject after a standard vision correction surgery and a custom vision correction surgery from the examination data; and when the vision correction surgery using the laser is available for the subject, suggesting a vision correction surgery corresponding to the subject from the examination data.

Abstract: The present invention relates to a method for recommending a vision correction surgery, and the method according to one aspect of the present invention comprises: obtaining an examination data of a subject; predicting whether the vision correction surgery is suitable for the subject from the examination data; when the vision correction surgery is suitable for the subject, predicting whether the vision correction surgery using a laser is available for the subject from the examination data; when the vision correction surgery using the laser is available for the subject, calculating corneal shape factor prediction values of the subject after a standard vision correction surgery and a custom vision correction surgery from the examination data; and when the vision correction surgery using the laser is available for the subject, suggesting a vision correction surgery corresponding to the subject from the examination data.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: A method for determining a lens and apparatus using the method are disclosed. According to an embodiment, a method for determining a lens to be inserted into an eyeball during lens implant surgery using machine learning may be provided, the method comprising: obtaining a plurality of examination data of a person to be operated on; and determining a size of a lens to be inserted into an eyeball of the person among a plurality of lens sizes by inputting the obtained plurality of examination data of the person to a lens determination model, wherein the lens determination model is different from a formula for determining a lens to be inserted into an eyeball during lens implant surgery, and is trained based on examination data of patients who have had lens implant surgery in the past and size information of lenses inserted into eyeballs of the patients.

Abstract: The present invention relates to a method for recommending a vision correction surgery, and the method according to one aspect of the present invention comprises: obtaining an examination data of a subject; predicting whether the vision correction surgery is suitable for the subject from the examination data; when the vision correction surgery is suitable for the subject, predicting whether the vision correction surgery using a laser is available for the subject from the examination data; when the vision correction surgery using the laser is available for the subject, calculating corneal shape factor prediction values of the subject after a standard vision correction surgery and a custom vision correction surgery from the examination data; and when the vision correction surgery using the laser is available for the subject, suggesting a vision correction surgery corresponding to the subject from the examination data.

Abstract: A method of arranging components in an integrated circuit includes providing two or more circuit cells of a first type and providing two or more circuit cells of a second type. The circuit cells of the first type are configured to operate in conjunction with the circuit cells of the second type. The method further includes arranging the circuit cells of the first and second types in an alternating pattern such that each circuit cell of the first type is adjacent to at least one circuit cell of the second type. The alternating pattern may be an array of rows and columns and may include a repeating pattern of one first type cell and one second type cell in each of the columns. The alternating pattern may include a repeating pattern of one cell of the first type and two cells of the second type in each of the columns.

Abstract: A method of driving a pixel array includes providing a ramp signal to one or more columns of the pixel array. For each cycle of the ramp signal, the method further includes providing a first row driving signal to at least a first row of the pixel array and a second row driving signal to a second row of the pixel array. A pixel array driver may include a ramp signal generator configured to produce a ramp signal, a first amplifier configured to receive the ramp signal and produce a first amplified ramp signal, and a second amplifier configured to receive the ramp signal and produce a second amplified ramp signal. The first amplified ramp signal may be electrically connected to a first set of pixels of a pixel array, and the second amplified ramp signal may be electrically connected to a second set of pixels of the pixel array.

Abstract: Disclosed is a camera module capable of simplifying a structure and facilitating assembly and disassembly. The camera module includes a lens unit, an AF assembly which adjusts advance and retreat movement in an optical axis direction of the lens unit, and an OIS assembly which is provided as an independent module structurally separated from the AF assembly and allows the AF assembly to move in a direction vertical to the optical axis direction of the lens unit, and the AF assembly and the OIS assembly are provided separately and assemblably in an independent modularized to each other.