Abstract: A device includes a servo controller that includes or that is coupled to memory. The memory stores multiple distinct disturbance control schemes. The servo controller is configured to select and implement one of the disturbance control schemes in response to receiving a command from a host. The servo controller can be implemented on a system on a chip.

Abstract: A hard disk assembly (HDAs) that include a tuning data memory at least including tuning data regarding the HDA. The HDAs may lack an internal disk controller, but rather may communicate the tuning data and/or other HDA-specific data (e.g., firmware, certification data, etc.) to a reader device comprising a disk controller. In this regard, the reader device may coordinate with the HDA once the tuning data is received to operate the HDA to perform TO commands in response to commands received at the reader device from a host. In turn, upon failure of an HDA, a new HDA may be swapped into place to communicate with the reader device. Because the HDAs may lack onboard disk controllers, the cost and complexity of each HDA may be reduced.

Abstract: Systems and methods for determining a trajectory of an elongated tool and for striking the target using the elongated tool are disclosed. The system for determining a trajectory of an elongated tool includes a memory module configured to receive imaging data of a preliminary 3-dimensional (3D) image of a body from a 3D imaging device, the body comprising an opaque body surface, a target and at least one occlusion between the body surface and the target, and a processor communicatively coupled with the memory module. The processor is configured to process the preliminary 3D image of the body from the 3D imaging device to obtain location data of the target, body surface and at least one occlusion; and based on a location of the target relative to the body surface and at least one occlusion, determine at least one trajectory for the elongated tool to strike the target.

Abstract: A data storage system can connect a cache memory to a caching module, a host, and a data storage device. The caching module can employ one or more local controllers to generate a caching strategy in response to detected data storage operations and execute the caching strategy to divide the cache memory into a first pool having a first size and a second pool having a second size.

Abstract: The invention includes procedures for stereoselective ?-acylation of carboxylic acids having a ?-carbon atom.

Abstract: The invention includes procedures for stereoselective ?-acylation of carboxylic acids having a ?-carbon atom.

Abstract: A system and an apparatus for guiding an instrument may be provided, the apparatus comprising a main body; a holding member for holding an instrument, the holding member coupled to the main body; and one or more actuating members configured to effect movement of the holding member such that said movement of the holding member is capable of providing rotational movement of an instrument about a pivot point external the apparatus. The holding member may preferably be configured to co-operate with a compliance device, said compliance device capable of holding the instrument.

Abstract: This invention discloses the first example of palladium(II)-catalyzed ?-C(sp3)-H iodination or arylation of a wide range of ketones by using a commercially available aminooxyacetic acid auxiliary. This L, X-type directing group overcomes the limitation of the transient directing group approach for -?C(sp3)-H functionalization of ketones. Practical advantages of this method include simple installation of the auxiliary without chromatography, exceptional tolerance of a-functional groups, double bonds and triple bonds and rapid access to diverse sterically hindered quaternary centers.

Abstract: We report the design of a catalytic, bifunctional template that binds heterocyclic substrate via reversible coordination instead of covalent linkage, allowing remote site-selective C—H olefination of heterocycles. The two metal centers coordinated to this template play different roles; anchoring substrates to the proximity of catalyst and cleaving the remote C—H bonds respectively. Using this strategy, we demonstrate remote site-selective C—H olefination of heterocyclic substrates which do not have functional group handles for covalently attaching templates. For instance the olefination can be an alkenylation of a 3-phenylpyridine with an acrylate alkyl ester selective for the meta position of the phenyl group with respect to the pyridine, or can be an alkenylation of a quinoline with an acrylate alkyl ester selective for the 5-position of the quinoline.

Abstract: A system and an apparatus for guiding an instrument may be provided, the apparatus comprising a main body; a holding member for holding an instrument, the holding member coupled to the main body; and one or more actuating members configured to effect movement of the holding member such that said movement of the holding member is capable of providing rotational movement of an instrument about a pivot point external the apparatus. The holding member may preferably be configured to co-operate with a compliance device, said compliance device capable of holding the instrument.

Abstract: Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

Abstract: This invention discloses the first example of palladium(II)-catalyzed ?-C(sp3)-H iodination or arylation of a wide range of ketones by using a commercially available aminooxyacetic acid auxiliary. This L, X-type directing group overcomes the limitation of the transient directing group approach for -?C(sp3)-H functionalization of ketones. Practical advantages of this method include simple installation of the auxiliary without chromatography, exceptional tolerance of a-functional groups, double bonds and triple bonds and rapid access to diverse sterically hindered quaternary centers.

Abstract: A data storage device that includes a data storage medium and a controller communicatively coupled to the data storage medium. The controller is configured to receive commands from a host and to detect a hung state in the data storage device. The controller is also configured to determine an execution status of a command, of the commands from the host, associated with the hung state. The controller is further configured to dynamically carry out a self-recovery operation in the data storage device to clear the hung state. The self-recovery operation includes steps that depend upon the execution status of the command associated with the hung state.

Abstract: A class of mono-protected 3-amino-2-hydroxypyridine (MPAHP) ligands that enable the meta-C—H arylation of anilines, phenols, phenylacetic acids, and biologically relevant heterocyclic compounds using norbornene as a transient mediator is disclosed, such as in the formation of a reaction product of Formula IA: The applicability of this meta-arylation methodology in the pharmaceutical industry is illustrated for heteroaryl substrates and heteroaryl iodide coupling partners, a feat made possible by using the MPAHP ligand. The enabling nature of MPAHP ligands to achieve other meta-C—H functionalization processes is also illustrated by the development of a meta-C—H amination reaction and a meta-C—H alkynylation reaction.

Abstract: We report the design of a catalytic, bifunctional template that binds heterocyclic substrate via reversible coordination instead of covalent linkage, allowing remote site-selective C—H olefination of heterocycles. The two metal centers coordinated to this template play different roles; anchoring substrates to the proximity of catalyst and cleaving the remote C—H bonds respectively. Using this strategy, we demonstrate remote site-selective C—H olefination of heterocyclic substrates which do not have functional group handles for covalently attaching templates. For instance the olefination can be an alkenylation of a 3-phenylpyridine with an acrylate alkyl ester selective for the meta position of the phenyl group with respect to the pyridine, or can be an alkenylation of a quinoline with an acrylate alkyl ester selective for the 5-position of the quinoline.

Abstract: A data storage device includes a data storage medium and a controller. The controller performs a boot-up sequence that includes operations that transition the data storage device from a lower operational state to a higher operational state in which the data storage device is ready to service host commands. The controller also carries out metadata updating operations independently of the boot-up sequence operations. Carrying out the metadata updating operations independently of the boot up sequence operations prevents the metadata updating operations from substantially contributing to a boot-up time.

Abstract: An alternative approach to formation of a C—C bond at a meta-position of an aromatic compound is disclosed that employs an ethylenically unsaturated bicyclic compound as a transient mediator to achieve meta-selective C—H activation with a simple and common ortho-directing group. The use of a pyridine-based ligand assists in relaying the palladium catalyst to the meta-position by the unsaturated bicyclic compound following initial ortho-C—H activation.

Abstract: A data storage device includes a data storage medium and a controller. The controller performs a boot-up sequence that includes operations that transition the data storage device from a lower operational state to a higher operational state in which the data storage device is ready to service host commands. The controller also carries out metadata updating operations independently of the boot-up sequence operations. Carrying out the metadata updating operations independently of the boot up sequence operations prevents the metadata updating operations from substantially contributing to a boot-up time.

Abstract: A data storage device that includes a data storage medium and a controller communicatively coupled to the data storage medium. The controller is configured to receive commands from a host and to detect a hung state in the data storage device. The controller is also configured to determine an execution status of a command, of the commands from the host, associated with the hung state. The controller is further configured to dynamically carry out a self-recovery operation in the data storage device to clear the hung state. The self-recovery operation includes steps that depend upon the execution status of the command associated with the hung state.

Abstract: Chiral acetyl-protected aminoethyl quinoline (APAQ), pyridine and imazoline ligands are disclosed that enable Pd (II)-catalyzed enantioselective arylation or heteroarylation of ubiquitous prochiral ?-methylene C—H bonds of aliphatic amides offers an alternative disconnection for constructing ?-chiral centers. Systematic tuning of the ligand structure reveals that a six-membered instead of a five-membered chelation of these types of ligands with the Pd(II) is important for accelerating the C(sp3)-H activation thereby achieving enantioselectivity for quinoline and pyridine ligands.