Abstract: A glucoside derivative, and a preparation method therefor and an application thereof. Specifically, provided is a glucoside derivative, which is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. The glucoside derivative can be used for treatment of diabetes mellitus II or diabetes mellitus I.

Abstract: The present invention provides a backlight module having a backplate, a position-limiting unit, a reflective sheet, a light guiding plate, and a light-emitting unit. The position-limiting unit is disposed on the backplate and has a position-limiting surface, a guiding surface, and a gap. The reflective sheet is disposed on the backplate and has a first side edge, a second side edge, a cutting line extending inward from the first side edge, and a bendable portion formed between the cutting line and the second side edge. The bendable portion abuts the position-limiting surface of the position-limiting unit and is guided by the guiding surface to extend into the gap as the reflective sheet expands along the position-limiting surface. The present invention also provides a display device having aforementioned backlight module and a display panel.

Abstract: A method for obtaining an antibody sequence includes: obtaining first features of amino acids at different sequence positions according to an antigen multiple sequence alignment (MSA) sequence, an antibody MSA sequence, and a concatenated sequence of the antigen MSA sequence and the antibody MSA sequence; obtaining second feature of the amino acids at different 3D coordinates according to a graph constructed according to a reference antigen-antibody complex; fusing the first features of amino acids at different sequence positions with the second features of amino acids at 3D coordinates corresponding to the different sequence positions, and obtaining probability information of each of the amino acids at different positions in the antibody sequence according to fused features; and obtaining a target antibody sequence according to the amino acids and their probability information at different positions in the antibody sequence.

Abstract: A method for protein docking includes docking a first protein and a second protein according to at least two molecular docking methods to generate a complex conformation in each round of iteration; recognizing that an iteration end condition is not satisfied, continuing a next round of iteration until the iteration end condition is satisfied, and obtaining a final complex conformation.

Abstract: A power converter and a method are disclosed. The power converter includes a converter circuit with a first electronic switch and a first inductor connected in series with the first electronic switch; a control circuit configured to control operation of the first electronic switch and comprising a first input node; and a sense circuit. The sense circuit includes a sense resistor connected in series with the first electronic switch; a second inductor inductively coupled with the first inductor and coupled to the first input node of the control circuit; and a first coupling circuit coupling the sense resistor to the first input node of the control circuit. The first coupling circuit includes a first resistor coupled between the sense resistor and the first input node, and a second electronic switch connected in parallel with the first resistor. The control circuit is further configured to control operation of the second electronic switch.

Abstract: An anode material includes an inner core, a first coating layer coated on a surface of the inner core, and a second coating layer coated on a surface of the first coating layer. The inner core includes silicon nanoparticles and titanium monoxide particles, the first coating layer includes silicon suboxide, and the second coating layer includes carbon fibers with a porous structure.

Abstract: A method of fabricating a semiconductor device includes etching a first trench and a second trench in an epitaxial layer over a semiconductor and forming a dielectric liner within the trenches. A photoresist layer is formed within the trenches and over the epitaxial layer and given a post-exposure bake at a first temperature. The photoresist layer is then given an adhesion-promoting bake at a greater second temperature; The photoresist layer is then removed from a top portion the trenches, thereby exposing a top portion of the dielectric liner and leaving a remaining portion of the photoresist in a bottom portion of the trenches. The exposed dielectric liner is etched, thereby leaving a remaining portion of the dielectric liner in the top portion of the trenches. The remaining portion of the photoresist is removed and the trenches are filled with a polysilicon layer.

Abstract: Disclosed is a method for synthesizing an O-antigen saccharide chain of Helicobacter pylori serotype O:6 using seven glycosylation building blocks. Inexpensive and easily available D-glucosamine, D-galactose, D-mannose and L-fucose are used as starting materials, and seven glycosylation building blocks are obtained through a series of chemical reactions. The saccharide building blocks are then selectively linked together to produce O-antigen oligosaccharide chains of Helicobacter pylori serotype O:6 with different saccharide configuration through a series of glycosylation reactions. Also disclosed is a method to assemble an amino linker at the reducing end of the O-antigen saccharide chain of Helicobacter pylori serotype O:6, and the synthesized oligosaccharide chain with an amino linker can be coupled to a carrier molecule or immobilized on a matrix.

Abstract: Pseudomonas and a use thereof are provided. The preservation number of the Pseudomonas is CGMCC No. 22583. The growth temperature of the Pseudomonas is 37-45° C. Under a medium-high temperature oil reservoir condition, the Pseudomonas can be denatured from a non-viscosity fluid to a multifunctional oil-extraction bacterial solution having both surface activity and viscoelasticity, and also has the functions of expanding the swept volume and improving the oil washing efficiency. The recovery ratio is increased by more than 20% in a physical simulation experiment.

Abstract: A T cell receptor (TCR) capable of specifically binding to a short peptide FMNKFIYEI derived from an AFP antigen. The antigen short peptide FMNKFIYEI can form a complex with HLA A0201 and be presented together with same to the cell surface. A nucleic acid molecule encoding the TCR, a vector comprising the nucleic acid molecule, and a cell that transduces the TCR.

Abstract: An image processing method includes segmenting, by a cloud server and based on a zoom ratio of a high-definition image in a high-definition image library, a low-definition image of a small zoom ratio from a terminal to obtain a plurality of image blocks. For each image block, performing, by the cloud server, retrieval and matching in the high-definition image library to obtain one or more high-definition reference images, and then performing, by the cloud server, image quality improvement using an image enhancement network that is based on the high-definition reference images to obtain a plurality of high-definition image blocks. Finally, stitching, by the cloud server, the high-definition image blocks into a super-definition image with higher resolution and higher definition, and returning, by the cloud server, the super-definition image to the terminal.

Abstract: Provided is a display substrate. The display substrate includes a base substrate, a wiring, and a first insulation layer. The first insulation layer covers the wiring. The wiring includes a first sub-layer and a second sub-layer. The first sub-layer is disposed on the base substrate, wherein a side wall of the first sub-layer is a first inclined surface. The second sub-layer is disposed on the base substrate and covers the first sub-layer, and the second sub-layer includes a first portion stacked on the first inclined surface, wherein a side wall of the first portion is a second inclined surface. An included angle between the second inclined surface and a bearing surface of the base substrate is less than an included angle between the first inclined surface and the bearing surface of the base substrate.

Abstract: The disclosure discloses a chemical synthesis method of oligosaccharides of a Pseudomonas aeruginosa serotype O11 O-antigen, and belongs to the field of chemistry. The disclosure includes constructing an O-antigen trisaccharide by using a D-glucose building block, an L-fucosamine building block and a D-fucosamine building block; wherein the D-glucose building block or the L-fucosamine building block is linked with the D-fucosamine building block through a 1,2-?-cis-glycosidic bond, the D-glucose building block is linked with the L-fucosamine building block through a 1,2-?-trans-glycosidic bond, and the construction of the 1,2-?-cis-glycosidic bond is conducted in a mixed solvent; and the mixed solvent includes two or more of dichloromethane, diethyl ether and thiophene.

Abstract: A data search apparatus includes a plurality of storage modules configured to store a data table. Any one of the plurality of storage modules stores a part of entries of the data table. Any entry in the data table is unique in the plurality of storage modules, and storage addresses of entries stored in at least one of the plurality of storage modules are inconsecutive.

Abstract: The disclosure discloses a glyco-metal-organic frameworks-based hepatic targeted therapeutic drug and a preparation method thereof, and belongs to the field of biomedicine. The disclosure loads a chemotherapeutic drug onto specific metal-organic frameworks, and modifies targeted molecule galactose on the surface of the materials through amide reaction. The biocompatibility and cytotoxicity of the obtained hepatic targeted therapeutic drug have been carefully evaluated at the cellular level. The hepatic targeted therapeutic drug of the disclosure has good stability and acidic pH triggered drug release property, and can exert the synergistic therapeutic effect of photodynamic therapy and chemotherapy. In addition, in vivo behavioral tracing and therapeutic efficacy are evaluated in mouse models with subcutaneous solid tumor and tumor in situ, and the disclosure is expected to play a huge role in clinical applications.

Abstract: A bit index explicit replication (BIER) operations, administration, and maintenance (OAM) detection method includes a bit forwarding ingress router (BFIR) obtaining a detection request packet based on a first BIER OAM packet, and sending the detection request packet to at least one bit forwarding egress router BFER. The detection request packet includes a first packet and a first packet header. The first packet is a packet obtained by encapsulating the first BIER OAM packet. The first packet header includes a bit string, and the bit string indicates the at least one bit forwarding egress router BFER that is to be measured.

Abstract: The present disclosure discloses an economical epoxy resin material for epoxy asphalt with low-temperature resistance and high flexibility as well as a preparation method thereof. The material comprises 60 parts of an epoxy resin main agent, 0.4 parts to 1.6 parts of a modifying gent, 31 parts to 36.5 parts of an active curing agent, 0.5 parts to 1.5 parts of a titanate coupling agent, and 1.6 parts to 6.4 parts of a reversible deformation additive.