Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: A method of making solid oxidesolid oxide electrolyte membrane comprises steps (S1)-(S5). Step (S1), mixing a high molecular polymer and a first solvent to form a first mixed slurry; and homogenizing the first mixed slurry, to obtain a reagent A. Step (S2), mixing an oxide powder, a dispersant and a second solvent to form a second mixed slurry, treating the second mixed slurry, to obtain a reagent B. Step (S3), adding a protective agent into the reagent B to form a third mixed slurry, and homogenizing the third mixed slurry to obtain a reagent C. Step (S4), mixing the reagent A and the reagent C to form a fourth mixed slurry, and treating the fourth mixed slurry a fifth mixed slurry; and homogenizating the fifth mixed slurry to form a solid electrolyte slurry. And step (S5), producing the solid oxidesolid oxide electrolyte membrane by a coating process.

Abstract: Embodiments of this specification provide for generating dialogue annotation data. A method includes: obtaining grammar that has been pre-generated in a target scenario, the grammar including a first phrase and a second phrase; the first phrase includes a first intent operation and a first variable of a first intent, where the first variable invokes other phrases. The second phrase assigns a value to the first variable and includes a property acquisition operation and a second variable of a second intent. Generating a target meaning representation of nested phrases for simulating a certain human-machine dialogue by invoking the first phrase and the second phrase in the grammar. Performing the first intent operations based on a property value corresponding to the first variable of the second variable assigned to the first variable.

Abstract: Embodiments are disclosed for receiving a modal input including at least one of a text input or an image input. The method may include extracting an intent label from the modal input. The method may further include generating, by an intent embedding generator, an intent embedding from the intent label. The method may further include comparing the intent embedding to a plurality of candidate font embeddings to obtain one or more candidate fonts based on a similarity of the intent embedding to the plurality of candidate font embeddings in an embedding space. The method may further include identifying a recommended font based on the similarity of the intent embedding to a selected candidate font embedding of the plurality of candidate font embeddings.

Abstract: Techniques related to query execution against an in-memory standby database are disclosed. A first database includes PF data stored on persistent storage in a persistent format. The first database is accessible to a first database server that converts the PF data to a mirror format to produce MF data that is stored within volatile memory. The first database server receives, from a second database server, one or more change records indicating one or more transactions performed against a second database. The one or more change records are applied to the PF data, and a reference timestamp is advanced from a first to a second timestamp. The first database server invalidates any MF data that is changed by a subset of the one or more transactions that committed between the first and second timestamps.

Abstract: This disclosure describes methods, non-transitory computer readable storage media, and systems that generate a digital knowledge graph based on a plurality of tutorial content items to generate recommendations of digital resource items. Specifically, the disclosed system extracts a plurality of tasks, subject categories related to the tasks, and context signals related to an environment for the tasks from a plurality of tutorial content items for one or more digital content editing applications. The disclosed system generates a digital knowledge graph including nodes corresponding to the tasks and subject categories connected via edges based on relationships extracted from the tutorial content items. In some embodiments, the disclosed system also includes nodes corresponding to digital resource items in the digital knowledge graph or in a subgraph. The disclosed system utilizes the digital knowledge graph with context data to provide a recommendation of digital resource items for display at a client device.

Abstract: The present disclosure relates to use of an aspirin compound in facilitating exogenous nucleic acid delivery and/or expression.

Abstract: This disclosure describes methods, non-transitory computer readable storage media, and systems that generate a digital knowledge graph based on a plurality of tutorial content items to generate recommendations of digital resource items. Specifically, the disclosed system extracts a plurality of tasks, subject categories related to the tasks, and context signals related to an environment for the tasks from a plurality of tutorial content items for one or more digital content editing applications. The disclosed system generates a digital knowledge graph including nodes corresponding to the tasks and subject categories connected via edges based on relationships extracted from the tutorial content items. In some embodiments, the disclosed system also includes nodes corresponding to digital resource items in the digital knowledge graph or in a subgraph. The disclosed system utilizes the digital knowledge graph with context data to provide a recommendation of digital resource items for display at a client device.

Abstract: Herein is high availability for online transaction processing with redundancy and redo for a federation of pluggable databases and container databases. In an embodiment of a federation of container database management systems that includes a first container database, first redo data of a first pluggable database in a second container database is obtained based on a database dictionary in the first container database. To the first pluggable database in the first container database, the first redo data of the first pluggable database in the second container database is applied. Based on the database dictionary in the first container database, second redo data of a second pluggable database in a third container database is obtained. To the second pluggable database in the first container database, without modifying content of the first pluggable database in the first container database, the second redo data of the second pluggable database in the third container database is applied.

Abstract: The present invention discloses a floor cleaning apparatus includes an upper body and a lower body. The upper body includes a lower housing a roller. The roller is arranged at an internal of the lower housing and is partially exposed externally. The lower housing includes a scraper for scraping foreign objects away from the roller. The roller includes a suction vent hood used sucking foreign objects via a negative pressure, and the scraper is adjacent to the suction vent hood to allow the scraped foreign objects to be sucked away by the suction vent hood directly. The roller includes a nozzle for ejecting a water for cleaning the roller. The present invention provides a cleaning apparatus with water ejection function. The roller can be cleaned through the water ejection and dirt can be sucked away by the negative pressure system, thereby achieving the proper cleaning effect with enhanced effect.

Abstract: A self-cleaning drying cleaning device includes a cleaning appliance with a cleaning brush head, and a cleaning storage seat used to store the cleaning appliance. The cleaning storage seat includes a cleaning storage seat main body including a housing provided with a storage portion that is used to store the cleaning brush head, an air drying device located inside the cleaning storage seat main body, and a control motherboard electrically connected to the air drying device and used to control the working mode of the air drying device. The housing has an air inlet and an air outlet. The air drying device directs wind from the air inlet to the air outlet and blows the wind to the storage portion to dry the cleaning brush head, avoiding the cleaning brush head being kept in a damp state after cleaning, keeping the cleaning brush head hygienic and clean.

Abstract: The present disclosure relates to a tyrosine hydroxylase (TH) variant lacking 60 to 120 amino acid residues at the N terminus, and a pharmaceutical composition comprising the TH variant lacking 60 to 120 amino acid residues at the N terminus and the aromatic L-amino acid decarboxylase (AADC). The present disclosure further relates to a nucleotide construct, a vector plasmid, a cell or a virus comprising the TH variant or the pharmaceutical composition, as well as use of the virus in the manufacture of a medicament for treating neurodegenerative diseases (e.g., Parkinson's Disease).

Abstract: Example lie-flat passenger seat configurations for transportation are described. A non-elevated passenger seat includes a seat base and a seatback pivotably connected to the sliding bar. The seat base may be opened upwardly or downwardly. The seatback may be opened sideway such that a space originally used for seat base and seatback is converted to a passage accessible by the passenger. An elevated-height passenger seat also includes a seat base, a seatback pivotably connected to the seat base, and a hinge at an upper portion of the seatback. The elevated-height passenger seat may rotate upwardly around the hinge. When the elevated-height passenger seat rotates upwardly, the elevated-height passenger seat transitions from a seating position to an elevated position with the seat base and the seatback forming a flat bed such that the passenger can lie flat on the flat bed formed by the seat base and the seatback.

Abstract: The present disclosure provides, inter alia, apparatuses for preparing a suppressor seal of a spark plug insulator assembly, and processes for fabricating and/or assembling a spark plug insulator assembly using the same. Also provided are automated systems for fabricating and/or assembling a spark plug insulator assembly, which includes an induction heating apparatus disclosed herein and other components such as, e.g., an auxiliary unit and a control unit, to automate and accelerate the manufacturing process.

Abstract: A spark plug includes an insulative sleeve. A glaze coating is disposed on an exterior surface of the insulative sleeve. The glaze coating includes a boric acid, a borosilicate glass, a barium borate glass, a phosphorous glass, a silicate glass, or a combination thereof. The glasses are independently modified with a modifier selected from the group consisting of alkali group metals, alkali earth group metals, aluminum, silicon, a halogen, or a combination thereof. The glaze coating has a softening point between about 650° C. and about 1100° C.

Abstract: Components of language processing engines, such as translation models and language models, can be customized for groups of users or based on user type values. Users can be organized into groups or assigned a value on a continuum based on factors such as interests, biographical characteristics, social media interactions, etc. In some implementations, translation engine components can be customized for groups of users by selecting the training data from content created by users in that group. In some implementations, the group identifier or continuum value can be part of the input into a general translation component allowing the translation component to take a language style of that user group into account when performing language processing tasks.

Abstract: Components of language processing engines, such as translation models and language models, can be customized for groups of users or based on user type values. Users can be organized into groups or assigned a value on a continuum based on factors such as interests, biographical characteristics, social media interactions, etc. In some implementations, translation engine components can be customized for groups of users by selecting the training data from content created by users in that group. In some implementations, the group identifier or continuum value can be part of the input into a general translation component allowing the translation component to take a language style of that user group into account when performing language processing tasks.

Abstract: The present invention relates to a system and method for providing a failover of storage for media content, including media content used for broadcasting in cinema. One embodiment of the invention stores copies of digital cinema packages (“DCPs”) to both a central storage facility as well as a local storage facility. When a server module reading DCPs in central storage module encounters abnormalities, it switches reading operations to the local storage module, at the same frame location from which interruption occurred. The present invention provides a multi-layered storage system for cinema broadcasting of a movie to decrease likelihood of interruptions during a broadcast that may be caused by failure of the central storage facility.

Abstract: Techniques are provided for creating a backup of a source pluggable database (SPD) of a source container database and porting the backup for recovery into a different target container database. In an embodiment, a source database server retrieves metadata that describes backups of the SPD. The source database server inserts, into an unplugged pluggable database of the SPD, the metadata that describes each of the backups. For example, unplugging the SPD may automatically create the unplugged pluggable database. Eventually, the unplugged pluggable database may be plugged into the target container database. A target database server transfers the metadata that describes each of the backups from the unplugged pluggable database and into the target container database. Based on at least one backup and the metadata that describes backups of the SPD, the target database server restores a target pluggable database within the target container database.