Abstract: The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.

Abstract: The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.

Abstract: Methods for detecting an analyte in a body fluid are described as well as devices and systems adapted for performing such methods. In embodiments of the method, a sample of body fluid is applied to a test element having at least one test field including at least one test material that is adapted to change at least one measurable property in the presence of the analyte. The test element further includes a capillary to guide the sample across said test field in a flow direction. The test element also includes first and second measurement locations offset from each other in the flow direction. The measurable property is measured in at least one first measurement location, providing at least one first measurement value, and it is measured in at least one second measurement location, providing at least one second measurement value.

Abstract: The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.

Abstract: A system for withdrawing body fluid is described which has a housing with at least one opening and at least one lancet which is elongate and substantially straight in its original and unused form. The lancet has a distal end with a lancet tip for carrying out a lancing operation. The system also includes a drive unit for driving the lancet in a drive direction and at least one guide element which makes contact with the lancet at least during the lancing operation and guides the lancet movement such that the lancet is bent relative to the drive direction. The lancet can have a high restoring force such that it returns to its original substantially straight shape after contacting the guide element.

Abstract: A test element includes a puncture element and a test panel. The puncture element has a tip positioned at one end for generating a wound in a body part. A capillary structure extends from the tip to the test panel and has a fluid connection to the tip. The test panel contains at least a part of a reagent system and is positioned in the test element adjacent to a part of the capillary structure of the puncture element so that body fluid penetrating into the capillary structure contacts a liquid entry side of the test panel. The test panel comprises a transparent support layer and a test layer applied to the support layer by coating. The side of the test panel facing away from the support layer forms its liquid entry side, which faces toward the capillary structure.

Abstract: The invention relates to a magazine for a device of a measuring system for determining an analyte concentration in a body fluid sample, wherein the magazine contains consumable analytical elements in a plurality of chambers. According to the invention, a data carrier, on which information is stored, is fastened to the magazine, the information indicating which magazine chambers are not intended for removal of a consumable element due to manufacturing defects. The invention further relates to a device, the control unit of which suppresses access by the removal unit to predefined magazine chambers, to a measuring system comprising such a device and a magazine, and to a method for controlling the removal unit of the device.

Abstract: The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.

Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.

Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

Abstract: An analytic magazine is proposed, which comprises at least one chamber with at least one analytic aid. The analytic aid comprises at least one test element for detecting at least one analyte in a sample of a bodily fluid. The test element has at least one test field with at least one test chemical. The test field is at least partly arranged within the chamber, wherein at least one wall of the chamber at least partly covers the test field and at least partly delimits a test-field surface that is accessible from the chamber.

Abstract: The invention concerns an analytical instrument for assaying body fluids, the instrument having the following features: a) a housing provided with a receiving element for engaging a body part, b) an abutment for the body part which can be moved between a release position and an operating position relative to the receiving element, c) a lancing unit having a lancing element that can pierce the body part resting against the abutment in a linear lancing stroke, d) a test tape unit having a test tape for receiving body fluid issuing from the body part, and e) a detection unit for examining the body fluid applied to a section of the test tape.

Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Abstract: An analysis system is provided which comprises an integrated analysis device and a test strip magazine, for determining an analyte in a body fluid, wherein the analysis system comprises a first group comprising reusable components and a second group of components comprising a plurality of disposable articles. The second group includes non-electronic and electronic components, with critical interfaces configured between two or more such components, wherein non-electronic components can be disconnected from electronic components at a disconnection point. In one embodiment, critical interfaces are produced and tested during production of the analysis system.

Abstract: The invention concerns a test device, in particular for blood sugar tests, comprising a lancing element which is provided with a lancing component for producing a skin puncture, and a protecting element shielding the lancing element at least in the area of the lancing component. According to the invention it is proposed that the lancing element has a collecting structure for collecting body fluid from the skin puncture and that the protecting element comprises a protecting foil to cover the collecting structure and a holding body for holding the protecting foil on the lancing element.

Abstract: There is disclosed a method for controlling a photometric measuring unit of a measuring device for a bodily fluid sample, wherein a test field partially wetted by a bodily fluid sample is illuminated and light from a measuring area that covers a portion of the test field of the measuring unit is fed to a detector of the measuring unit, and the measuring area is displaced relative to the test field toward a partial surface wetted by the fluid sample and past the partial surface. The intensity of a detector signal is detected during the displacement, an extreme value in the course of the detector signal is determined, the measuring area is brought back to the position in which an extreme detector signal was previously measured, and the position of the measuring area in which the detector signal is extreme is used for a photometric determination of concentration.

Abstract: A portable measuring system which analyzes a liquid sample for at least one analyte. The portable measuring system has a substantially moisture-proof housing with an internal atmosphere. The housing prevents moisture from the air and water vapor from penetrating into the housing. The portable measuring system also has at least one test element support inserted into the internal atmosphere of the housing. The test element support is equipped with a retaining structure and a test element that is supported by the retaining structure. The test element support is designed such that, after insertion into the internal atmosphere, the test element is exposed to the internal atmosphere. A release mechanism is also provided which can convey at least one test element into an application position within the internal atmosphere of the housing. In this application position, the liquid sample can be applied to the test element.

Abstract: Lancing system comprising a needle and a lancing device The lancing device comprises a housing with a housing opening that is surrounded by a housing skin contact surface. A lancing depth reference element with a reference skin contact surface is adapted in such a manner that the reference skin contact surface at a reversal point of the lancing movement is in contact with the skin. The lancing depth is determined by the distance between the reference skin contact surface and the tip of the needle element at the reversal point of the lancing movement. The lancing depth reference element is in a stationary defined position relative to the reversal point of the lancing movement. The lancing depth reference element is adapted to stabilize the skin when pressed against the reference skin contact surface with respect to a skin deformation which occurs upon lancing of the skin.