Abstract: The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.

Abstract: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.

Abstract: The present invention is generally directed towards a reagent system for detecting an analyte in a sample. The reagent system has a detection reagent comprising an enzyme-coenzyme complex in a form such that no regeneration of the coenzyme takes place, whereby the enzyme-coenzyme complex is employed in an at least stoichiometric amount relative to the analyte present in the sample, and a support to receive the detection reagent.

Abstract: The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element.

Abstract: A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte.

Abstract: A reagent for detecting an analyte by a redox reaction and a fluorimetric determination is disclosed. The reagent comprises a compound of formula (I): wherein R1 and R2 are each independently selected from R, (CH2CH2O)mR, COR, COOR, and OCOR; each R3 is independently selected from NO2, CN, R, OR, OCOR, COOR, SR, and halogen; R is H or C1-C4 alkyl, where alkyl is optionally substituted with one or more functional group independently selected from the group consisting of halogen, OR, SR, NR2, COOR, CONR2, SO3R and salts thereof, and PO(OR)3 and salts thereof; m is an integer from 1 to 20; and n is 1, 2, or 3. The reagent may further comprise an enzyme or a coenzyme for reducing or oxidizing an analyte.

Abstract: A system for analyzing a bodily fluid is described, which contains at least one lancing element, such as a lancet, stored in a first magazine, and at least one test element with a detection area, stored in a second magazine, the detection area containing reagents if necessary for use in detecting the analyte. The system also includes a housing, which encloses at least part of the first magazine and the second magazine and includes an opening for placement of a body part. At least one of the lancing elements and at least one of the test elements are located below the opening, and one of the magazines is located at least partly between the opening and the other magazine. The two magazines may at least partially overlap. The lancing element and the test element may be moved toward the opening so the body part resting on the opening can be lanced with the lancing element and the emerging bodily fluid can be collected using the test element at the same opening.

Abstract: The invention concerns an analytical system and a method for determining an analyte which ensures an exact determination by correcting the measured values based on sample- and analyte-independent light intensity changes. The invention takes into account light intensity changes which are based on changes of measurement conditions in the apparatus. The invention is particularly suitable for use in analytical systems for glucose determination in which light-conducting test elements are used.

Abstract: The present invention concerns a body fluid testing device (10) for analyzing a body fluids, comprising a test media tape (30) adapted to collect the body fluid, a supply portion (100) storing an uncontaminated section of the test media tape, a storage portion (110) for storing a contaminated section of the test media tape, an exposure portion positioned between the supply portion and the storage portion, the exposure portion being adapted to expose a section of the test media tape to the body fluid. An important aspect is a tip portion (20) for exposing a test medium to body fluid application. The application further concerns a test media cassette for housing test media. Another aspect is a testing device and method that employs illumination of a test medium at the site for body fluid application.

Abstract: The invention concerns methods and reagent kits for the fluorimetric determination of analytes.

Abstract: Lancing system for extracting a body fluid from the skin of a human or animal comprising a needle element (3) for lancing the skin, a lancing device (2) which includes a lancet drive (15a), by which a lancing movement of the needle element (3) coupled with the lancet drive by means of a coupling mechanism (28) is driven in lancing direction, wherein the lancing device (2) comprises a housing (4) with a housing opening (5) at its in lancing direction front end and the housing opening (5) is surrounded by a housing skin contact surface (7) which is pressed against the skin when using the lancing device (2), the needle element (3) is moved on a predetermined lancing path in a lancing direction in a forward phase of the lancing movement until its tip (3c) enters the skin in order to create a wound and in a return phase of the lancing movement following the reaching of a reversal point corresponding to the lancing depth (S) in the skin is retracted again, a lancing depth reference element (8) with a reference skin

Abstract: A system is described for determining the concentration of an analyte in a liquid by absorption measurement comprising a test element with a detection area which contains at least one reaction area with reagents for detecting the analyte which cause a change in the absorption behavior upon reaction with the analyte. The detection area contains at least one reference area in which the absorption behavior is substantially not changed when wetted by a sample having the analyte. Furthermore, the system contains a detection unit for the spatially resolved detection of light intensities which are received from the detection area and an evaluation unit for evaluating signals from the detection unit. Further embodiments of the system comprise reaction areas and reference areas arranged alternately in two dimensions.

Abstract: The invention concerns test elements and methods for the optical detection of an analyte in a sample. The test element includes a support having at least one transparent portion, and a one-layer film positioned on the support. The film has a thickness when dry of less than about 10 ?m. The method includes contacting the sample with the test element and determining the analyte concentration in the sample.

Abstract: The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.

Abstract: A portable measuring system which analyzes a liquid sample for at least one analyte. The portable measuring system has a substantially moisture-proof housing with an internal atmosphere. The housing prevents moisture from the air and water vapor from penetrating into the housing. The portable measuring system also has at least one test element support inserted into the internal atmosphere of the housing. The test element support is equipped with a retaining structure and a test element that is supported by the retaining structure. The test element support is designed such that, after insertion into the internal atmosphere, the test element is exposed to the internal atmosphere. A release mechanism is also provided which can convey at least one test element into an application position within the internal atmosphere of the housing. In this application position, the liquid sample can be applied to the test element.

Abstract: The invention concerns a device for collecting body fluids which has at least one lancet comprising a lancet body with at least two tips of different lengths. The device is characterized in that it has a selection means with the aid of which only one tip is selected before the lancing. This selection means can have different functions and shapes. The selection means is used to select a tip from a plurality of lancet tips which have different lengths and make only this tip available for use in the lancing process. Since the various tips are attached to a lancet body, it is, for example, possible to use a bending element which bends one of the various tips out of the plane of the lancet body in order to provide only one lancet tip for use. This is especially preferable for lancet tips that are arranged linearly relative to one another.

Abstract: The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.

Abstract: The invention concerns a method for detecting an underdosage of an analytical test element and optionally for compensating the underdosage. The invention also concerns an analytical system and a test element which are suitable for detecting an underdosage. An underdosage of the test element can be reliably detected and optionally calculated by irradiating the analytical test element in a control wavelength range. For this purpose the test element contains a control substance which interacts with the radiation in the control wavelength range as a function of the contact with the applied amount of sample.

Abstract: The invention is related to a lancet wheel (1) having a plurality of lancets (2) in a ring-shaped arrangement, the lancets (2) comprising a lancet body (4) that ends in a lancet tip (3). A lancet wheel (1) according to the invention has a carrier (5) that carries the lancets (2), whereby the lancets (2) are connected to the carrier (5) via bars (7, 7a, 7b, 7c) that allow for mobility of the lancets (2) relative to the carrier (5).

Abstract: The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.

Abstract: There is provided a new and useful removable lid, particularly adapted for commercial sized containers of the type which holds oils, grease, bulk food stuffs and the like. The lid comprises a central lid area which has parallel upper and lower surfaces. A continuous channel extends about the periphery of the lower surface. The channel has inner and outer walls for releasably receiving therebetween the upper lid of a container. A skirt downwardly depends about the periphery of the lid area. The skirt forms part of the outer wall of the channel. Means at the bottom of the channel act as a seal between the lid and the container when the lid is in position on the container.