Abstract: An extended release formulation is provided for use in a method for the treatment of Central Precocious Puberty (CPP) in pediatric patients 2 years of age or older. The extended release formulation comprises leuprolide or a pharmaceutically acceptable salt thereof, a biodegradable polymer, and a biocompatible organic solvent. The biodegradable polymer is comprised of poly(lactide-co-glycolide) (PLG) copolymer segments, poly(lactic acid-co-glycolic acid) (PLGA) copolymer segments, poly(lactide) (PL) polymer segments, poly(lactic acid) (PLA) polymer segments, or a combination thereof. The extended release formulation is administered as a subcutaneous injection of a flowable composition that forms a solid in situ depot. The extended release formulation releases leuprolide for a period of about 6 months for the effective treatment of CPP within a pediatric patient.

Abstract: An axial seal assembly is for sealing against a radial engagement surface of an outer member or an inner member disposed within a bore of the outer member. The seal assembly includes an annular case coupled with the outer member or disposed about the inner member and an annular elastomeric seal body. The seal body includes an inner portion attached to the case and an outer portion extending axially and radially from the inner portion so as to be positionable generally parallel to the radial engagement surface. The outer portion has a contact section extending generally axially from a remainder of the outer portion and being sealingly engageable with the radial engagement surface, the seal body outer portion being bendable about the seal body inner portion such that the seal body outer portion remains parallel to the engagement surface during axial displacement between the annular case and the engagement surface.

Abstract: A seal assembly is for sealing a rotating device and includes a dynamic seal component frictionally engageable with a device rotor and a static seal component frictionally engageable with a device stator. The two seal components are formed therebetween with a contact seal based on a sealing lip and a non-contact seal based on a labyrinth gap. The labyrinth gap is located upstream of the sealing lip on the path of foreign matter entering the seal assembly. A thrust bumper is formed in the labyrinth gap and defines a gap width by its own height during the assembly process. The rotating device may be a hub unit of a vehicle or any rotating machine with a rotor and a stator as core components. The rotating equipment adopting the present seal assembly can obtain significantly improved sealing performance, and thus is fully adapted to severely polluted or extremely humid working conditions.

Abstract: Compositions and methods for suppressing ovarian function in subjects with hormone receptor-positive breast cancer.

Abstract: A seal assembly is for sealing an annular space between a shaft and a housing, the housing having a bore and a radial end surface extending outwardly from the bore. The seal assembly includes an outer case disposeable within the housing bore, configured to support a primary seal member and having a radially-outwardly extending flange disposeable against the housing radial surface, the flange defining an annular groove. An inner case is disposed within the outer case and is disposeable upon the shaft. An annular retainer formed of a rigid polymeric material has an outer radial end disposed within the flange groove, an inner radial end disposeable about the shaft and a radial retention surface. The retainer retention surface extends between the inner and outer ends and is contactable by the inner case so as to retain the inner case disposed within the outer case.

Abstract: An apparatus (200) includes a cryostat (202) containing a volume of myogenic fluid. One or more electrically superconducting coils (204) is disposed within the cryostat. The one or more electrically superconducting coils is configured to produce a magnetic field when an electrical current is passed therethrough. One or more high temperature superconducting (HTS) current leads (206) is permanently disposed within the cryostat and coupled to the one or more electrically superconducting coils. One or more sensors (222) is positioned at or near the one or more HTS current leads to monitor the status of the HTS current leads. An HTS protection switch (208) is selectively coupled to the one or more HTS current leads. A magnet controller (220) controls the HTS protection switch to divert current from the one or more HTS current leads upon detection via the sensors of a quench of the one or more HTS current leads.

Abstract: Techniques are described herein for using a high-pressure reactor to separate clean water from dirty water without filtration and to extract and concentrate contaminants from dirty water for use as a fuel. In particular, techniques and systems are described for separating water from hydrocarbon contaminates, other BTU-laden compounds, and dissolved minerals, while also boiling water and condensing the resulting steam into distilled water. In addition, system in which the described techniques are performed can be used as a high-pressure pump for moving the separated hydrocarbon contaminates forward into other processes, such as a high-pressure reactor or incinerator.

Abstract: The present disclosure relates to applicators for microneedle array patches and methods of application of microneedle array patches to a skin surface. The applicator can include a shaft having an opening at a first end for affixing a microneedle array patch, a plunger positioned substantially within the shaft, a loading mechanism operably associated with the plunger within the shaft, and a force applicator. The method can include affixing the microneedle array patch to a first end of a plunger of a microneedle array patch applicator, loading the plunger and the affixed microneedle array patch to a loaded position, positioning the opening against the skin region of the individual and operating the force applicator to release the plunger.

Abstract: The invention provides an improved host strain for production of desired protein.

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: A wheel hub and removable bolt ring assembly for air disk braking system includes a hub cylinder, a bolt ring, a locking collar, a plurality of L-shaped locking recesses, and a plurality of rotor mounts that are concentrically positioned around a central axis. The plurality of rotor mounts is positioned adjacent to an outboard end of the hub cylinder. The plurality of L-shaped locking recesses radially traverses into the hub cylinder. The bolt ring and the locking collar are positioned in between the outboard end and an inboard end of the hub cylinder. A plurality of locking splines of the bolt ring is removably mounted around the hub cylinder through the plurality of L-shaped locking recesses. A plurality of locking tabs of the locking collar is removably mounted around the hub cylinder through the plurality of L-shaped locking recesses.

Abstract: There is provided a multipole magnet for deflecting a beam of charged particles. The multipole magnet comprises a plurality of ferromagnetic poles and a plurality of permanent magnet assemblies to supply a magnetomotive force to the ferromagnetic poles. At least one of the permanent magnet assemblies has a plurality of discrete permanent magnet positions and a plurality of permanent magnets each fixed in one of the permanent magnet positions.

Abstract: A system and apparatus for recording and archiving diverse communications over radio transmissions. The system and apparatus enables unattended airports within a geofenced area to generate a useful archive of all radio communications made by Automatic Dependent Surveillance-Broadcast (ADS-B) equipped aircraft and ground personnel. A combination of hardware and software components are provided to record and store radio transmissions in computer files. Recording archiving and reporting of received and stored data includes aircraft identification, location and heading and other data, including time-based data within one or more user-defined polygons.

Abstract: A reinforced composite laminate for an aircraft and a method of manufacture thereof. The laminate includes a set of stacked plies of pre-preg material laid up forming an XY plane, wherein the laminate further includes a plurality of elongated carbon pins including a round section with a diameter smaller than 0.5 mm. The pins are nailed through the stacked plies following the Z direction to withstand the out-of-plane loads.

Abstract: A system (100) for controlling temperature of a persistent current switch (120) operating in a background magnetic field includes a heat exchanger (138), a loop tube (135), a ball valve (245) and multiple electromagnets (251, 252). The heat exchanger disperses heat to a cryocooler (106). The loop tube enables flow of coolant to convectively transfer thermal energy generated by the persistent current switch to the heat exchanger. The ball valve is integrated with the loop tube between the persistent current switch and the heat exchanger, and contains a ferromagnetic ball (250). The electromagnets are positioned outside the loop tube adjacent to the ball valve, where energizing a first electromagnet of the multiple electromagnets magnetically moves the ferromagnetic ball to a first position opening the loop tube and enabling the flow of the coolant, and energizing a second electromagnets magnetically moves the ferromagnetic ball to a second position closing the loop tube and blocking the flow of the coolant.

Abstract: A mobile ordnance disposal system to dispose of unexploded ordnance in situ by cutting open the ordnance casing and subjecting the explosive material to heat in order to burn the explosive material held within the casing in a controlled manner instead of generating an explosion to effect disposal. By using the system, the operator may remain at safe, remote distance controlling the system operation.

Abstract: A data processing method and apparatus, the method comprising: storing, at a first memory location in a memory, a first copy of a set of data; storing, at a second memory location in a memory, a second copy of a set of data; comparing the first copy to the second copy so as to identify, within the first copy, a pointer, the pointer being located at a first data element of the first copy, the pointer specifying a second data element of the first copy; determining an offset for the identified pointer, the offset specifying a number of data elements between the first data element and the second data element; and modifying the first copy such that the pointer within the first copy specifies the second data element using only the first data element and the offset.

Abstract: A thin-film coating applicator assembly is disclosed for coating substrates in outdoor applications. The innovative thin-film coating applicator assembly is adapted to apply performance enhancement coatings on installed photovoltaic panels and glass windows in outdoor environments. The coating applicator is adapted to move along a solar panel or glass pane while applicator mechanisms deposit a uniform layer of liquid coating solution to the substrate's surface. The applicator assembly comprises a conveyance means disposed on a frame. Further disclosed are innovative applicator heads that comprise a deformable sponge-like core surrounded by a microporous layer. The structure, when in contact with a substrate surface, deposits a uniform layer of coating solution over a large surface.

Abstract: The invention provides an improved host strain for production of desired protein.

Abstract: Methods, systems, and computer program products for designing conflict minimizing outreach strategies are provided herein. A computer-implemented method includes obtaining data from a job matching service corresponding to jobs listed on the job matching service and candidates; generating job clusters for the jobs based on clustering criteria; identifying, for each respective one of the job clusters, a set of candidates from among the candidates to reduce inter-cluster conflict; selecting, for each of the jobs in a given one of the job clusters, individual candidates from among the set of candidates corresponding to the given job cluster to reduce intra-cluster conflict with respect to the plurality of candidates; and outputting one or more optimized lists of the candidates for the jobs based on the identifying and the selecting.