Abstract: Systems and methods for user-guided iterative node discovery and topology discovery in a network of nodes involved in secure and reliable data transfer.

Abstract: A system and method for facilitating analysis and modification of a computer program. A directed graph is generated from an intermediate language representation of a computer program function, with a node representing each instruction. Meta-edges or meta-nodes are inserted into the directed graph to facilitate location of instruction nodes. One type of meta-edge is a back edge that identifies branch instruction nodes. Some meta-nodes may identify instructions of a specific type. Some meta-nodes may identify exception blocks and corresponding handlers. Analysis of a program function may include insertion of new instructions prior to execution of the function.

Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

Abstract: A method comprising forming a coating solution which comprises a matrix precursor material, a porogen material and a solvent, by selecting a polyarylene matrix precursor material which cross-links to form a matrix with a calculated cross-link moeity density of at least 0.003 moles/ml, and reacting the polyarylene matrix precursor material with a porogen which is linear oligomer or polymer which is formed from monomers comprising alkenyl or alkynyl functional monomers, which has reactive end groups and a weight average molecular weight in the range of less than about 5000, where the porogen is present in amounts in the range of about 10 to less than 50 percent by weight based on total weight of porogens and matrix precursor material.

Abstract: The present invention is directed to the use of yeasts to produce spiroketal fragrance materials. The preferred yeasts used in the method of the invention are Bensingtonia ciliate and Cryptococcus laurentii.

Abstract: Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor, such as decitabine, preferably in combination with an effective amount of a histone deacetylase inhibitor. The compositions, kits and methods can be used to treat or present neurological disorders such as Lou Gehrig's disease, fragile X syndrome, Parkinson's disease and Alzheimer's disease.

Abstract: The invention provides compounds of the formula (I) or a salt, solvate or N-oxide thereof, wherein: R1 and R2 are the same or different and each is selected from hydrogen, saturated C1-3 hydrocarbyl, halogen and cyano; X is selected from C?O, C?S, C(?O)NH, C(?S)NH, C(?O)O, C(?O)S, C(?S)O and C(?S)S; R3 is selected from aryl and heteroaryl groups each having from 5 to 12 ring members and being unsubstituted or substituted by one or more substituent groups R10 as defined in the claims; R4 and R5 are the same or different and are selected from hydrogen and methyl; or one of R4 and R5 is selected from hydroxymethyl and ethyl and the other is hydrogen; and R6 and R7 are the same or different and are selected from hydrogen and methyl. The compounds of the formula (I) hayed activity as p38 MAP kinase and Taf kinase inhibitors.

Abstract: Methods are provided for treating patients with hematological disorders such as acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and the myelodysplastic syndromes (MDS). By administering a DNA methylation inhibitor to the patients following unique dosing regimens, the diseases can be efficaciously treated with reduced toxic side effects.

Abstract: A watertight connector for an RV sewer line and a conventional garden hose is provided to limit or prevent leakage when water from the garden hose is used to clean the sewer line. The connector comprises a cone, a threaded nut, a washer that forms a seal within the nut, a male fitting that fits over a female RV sewer line, and securing pins for securely attaching the male fitting to the sewer line. The nut may be a moveable swivel-type nut or may comprise the material tip of the cone. The user attaches the nut to the tip of a garden hose and the male fitting at the base of the cone to an RV sewer line and secures the fitting with the securing pins. Afterwards, the user turns on the garden hose, so that water from the hose cleans the sewer line without leaking from the connector.

Abstract: A particle detection system uses a reflective optic comprising a curved surface to detect high angle scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. When the particles transit the laser beam, light is scattered in all directions and is described by MIE scattering theory for particles about the size of the wavelength of light and larger or Rayleigh Scattering when the particles are smaller than the wavelength of light. By using the reflective optic, the scattered light can be detected over angles that are greater than normally obtainable.

Abstract: Methods are provided for treating diseases associated with abnormal activity of kinases. The method comprises: administering a DNA methylation inhibitor to the patient in therapeutically effective amount; and administering a kinase inhibitor to the patient in therapeutically effective amount, such that the in vivo activity of the kinase is reduced relative to that prior to the treatment.

Abstract: Systems and methods for user-guided iterative node discovery and topology discovery in a network of nodes involved in secure and reliable data transfer.

Abstract: An active damping arrangement for a power conditioning circuit comprising a converter or an inverter and an electronically driven output line having an output terminal for connecting to an external load, the active damping arrangement comprising an inductor-capacitor low-pass output filter (OPF) for connecting between an output of the inverter/converter (PWMVC or BBHCC) and the output terminal; means for sensing current in or voltage across the capacitor or voltage between one end of the capacitor (C) and an effective neutral point; means for multiplying the sensed voltage or current by a coefficient G to provide a damping signal, and means for feeding back the damping signal to an input of the inverter/converter (PWMVC or BBHCC), thereby to damp the output of the inverter/converter.

Abstract: A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation, the method comprising: administering to the patient a 20(S)-camptothecin for a period of time during which a pyrimidine base analog is not being administered to the patient; and administering a pyrimidine base analog to the patient.

Abstract: Methods are provided for treating diseases associated with abnormal activity of kinases. The method comprises: administering a DNA methylation inhibitor to the patient in therapeutically effective amount; and administering a kinase inhibitor to the patient in therapeutically effective amount, such that the in vivo activity of the kinase is reduced relative to that prior to the treatment.

Abstract: An apparatus for the improvement of AC waveform comprising means for applying a demand input waveform at an input of a circuit for power conditioning (including an inverter PWMVC or BBHCC) that is operable to provide an output waveform at an output; a feedback loop between the input and output, the feedback loop including means for sampling the output waveform (ADC1), means for subtracting a required waveform (RW) from the output waveform to produce an error waveform, means for processing the error waveform in a pre-defined manner to produce a processed error waveform (Clip1, Disc1, Att1), means for adding or subtracting the processed error waveform from Th. demand waveform to produce a revised demand waveform, and means for applying the revised demand waveform to the input of the power conditioning circuit at a subsequent time as an input demand waveform to produce a new AC output waveform at the output.

Abstract: A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation, the method comprising: administering to the patient a 20(S)-camptothecin for a period of time during which a pyrimidine base analog is not being administered to the patient; and administering a pyrimidine base analog to the patient.

Abstract: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

Abstract: Methods, compositions and kits are provided for treating cancer associated with protein tyrosine kinase activity such as chronic myelogenous leukemia. In particular, a treatment method is provided comprising: administering to a patient having chronic myelogenous leukemia and a degree of resistance to imatinib mesylate, a therapeutically effective amount of a DNA methylation inhibitor which mitigates the imatinib mesylate resistance.

Abstract: Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor, such as decitabine, preferably in combination with an effective amount of a histone deacetylase inhibitor. The compositions, kits and methods can be used to treat or present neurological disorders such as Lou Gehrig's disease, fragile X syndrome, Parkinson's disease and Alzheimer's disease.