Abstract: Systems, methods, and kits for treating, preventing, and diagnosing viral infection using an androgen mediated pathway are described. Additionally, methods and kits for guiding treatment of viral respiratory disease are described by a method for testing for polymorphisms in the androgen receptor gene. Further, systems and methods for treatment of viral respiratory disease with various anti-androgens is detailed. Finally, systems, methods, and kits for treating, preventing, and diagnosing SARS-CoV-2 (COVID-19) are presented.

Abstract: The present disclosure includes methods, systems, kits and compositions for treating, preventing and diagnosing viral infections, specifically SARS-CoV-2 infections, with an anti-androgen and anti-thyroid medication, a thyroid receptor antagonist, a TGF-? inhibitor or a combination thereof. The present disclosure also describes methods and compositions for the treatment of viral respiratory diseases, specifically SARS-CoV-2 infections, including anti-androgens, anti-thyroid medications, thyroid receptor antagonists, TGF-? inhibitors, RXR inhibitors, furin inhibitors or other agents to disrupt the androgen signaling.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are method of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: Hair shedding and other disorders related to mechanical pulling on hair are treated or prevented by administering a topical composition comprising a trace amine associated receptor agonist or another compound to contract the arrector pili muscle.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are method of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR?NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are method of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: Disclosed herein are compositions including a topical agent that may be used to reduce and/or inhibit the effects of chemotherapy and/or radiotherapy, which can include reducing and/or inhibiting the effects of hair loss and/or hair shedding due to chemotherapy and/or radiotherapy. The topical agent can be hydrogen sulfide, a hydrogen sulfide donor, or a substrate for a hydrogen sulfide producing enzyme such as sulfanegen. Some embodiments of the composition can include the topical agent combined with an agent to promote vasoconstriction or the topical agent combined with an agent to modulate deposition, mode of action, and/or metabolism of a chemotherapeutic agent and/or a reactive oxygen species agent. Embodiments can be used for improving the outcome of a hair transplant surgery by optimizing a holding solution to stabilize hair follicle grafts. In yet another embodiment, a system for realizing hydrogen sulfide slowly into a holding solution is described.

Abstract: This invention brings three new elements to the design of a low-power RTG; 1) an RHU suspension system, 2) a module tensioning system, and 3) a flexible thermal conductor. Taken together, these three elements enable the design of a system which finds optimal balancing of shock resistance with energy conversion efficiency.

Abstract: Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are method of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Abstract: The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a LINGO-4 antagonist.

Abstract: Disclosed herein are compositions of synephrine and a penetration enhancer and methods of reducing hair loss from pulling by applying the compositions. In one embodiment, the composition is a prewash composition comprising water, synephrine, and PEG-6 caprylic/capric glycerides.

Abstract: Powder layer smoothing devices (34) adapted for use with powder-layer three-dimensional printers (10) are described. The smoothing devices (34) include a counter rotating roller (36, 50, 60) having a complex powder engaging face (38) that may include a series or plurality of flutes (54) or may include knurling (64) extending along at least a portion of the counter rotating roller (36, 50, 60) along its rotational axis (56, 66). The smoothing device (34) may also include a vertically adjustable finishing roller (35) to follow the counter rotating roller (36, 50, 60) across the build box (12) of the powder-layer three-dimensional printer (10).

Abstract: Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells.

Abstract: The present invention relates to apparatuses for distributing build powder in powder-layer three-dimensional printers (2) and for the collection of particulates of the build powder that have become suspended in the gaseous atmosphere in the vicinity of the build platform of the three-dimensional printer. These apparatuses include recoaters (20) that are particularly useful in providing uniform distribution of fine build powder across the width of the build platform or powder bed. The present invention also includes powder-layer three-dimensional printers (2) which comprise such apparatuses for distributing build powder and/or apparatuses for collecting such suspended particulates. The improved fine powder recoater (20) uses an ultrasonic transducer (30) to move powder through a sheet screen (28). The sheet screen (28) may be presented to the powder fed onto it in a narrow dispensing slot to limit the flow rate of powder from the dispenser and to provide control over the amount of powder dispensed.

Abstract: The present invention relates to powder-layer three-dimensional printers (2) having a discrete supply hopper (340) and a recoater (20). The discrete supply hopper (340) is configured to transfer a build powder to the recoater (20) in a manner that enhances the uniformity of build powder layers that are dispensed from the recoater (20). In some embodiments, at least one of the discrete supply hopper and the powder hopper of the recoater is adapted to selectively contact the other, seal against the other, and/or have one partially inserted inside the other so as to diminish or prevent powder pluming during the transfer of build powder from the discrete supply hopper to the recoater.

Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay for sulfotransferase activity. In particular, SULT1A1 activity may be used as an indicator of minoxidil response. A genetic test for alleles of the SULT1A1 gene may be performed to provide a more personalized therapy.

Abstract: The present invention discloses compositions, methods, and systems of treating female sexual dysfunction by stimulating the contraction of the smooth muscle of the nipple. The smooth muscle in the nipple expresses trace amine associated receptors and thus can be contracted through a class of trace amine associated receptor agonists such as octopamine or tyramine, but any agent that promotes contraction of smooth muscle can be considered for the methods and compositions described herein. The contraction of the smooth muscle erects the nipple and increases female sexual arousal. The smooth muscle stimulatory compound can be formulated in a solution, foam, ointment, gel, spray, lotion, powder, topical cream, emulsion, slow release capsule or any similar method, compound, or delivery vehicle including a pre-wetted gauze or cotton pad. Additionally, the disclosed composition can be used to improve the quality of a sexual experience, e.g.

Abstract: Powder layer smoothing devices (34) adapted for use with powder-layer three-dimensional printers (10) are described. The smoothing devices (34) include a counter rotating roller (36, 50, 60) having a complex powder engaging face (38) that may include a series or plurality of flutes (54) or may include knurling (64) extending along at least a portion of the counter rotating roller (36, 50, 60) along its rotational axis (56, 66). The smoothing device (34) may also include a vertically adjustable finishing roller (35) to follow the counter rotating roller (36, 50, 60) across the build box (12) of the powder-layer three-dimensional printer (10).

Abstract: A powder layer smoothing devices adapted for use with powder-layer three-dimensional printers are described. The smoothing devices include a counter rotating roller having a complex powder engaging face that may include a series or plurality of flutes or may include knurling extending along at least a portion of the roller along the rotational axis. The smoothing device may also include a vertically adjustable finishing roller to follow the counter rotating roller across the build box of the powder-layer three-dimensional printer.