Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay for sulfotransferase activity. In particular, SULT1A1 activity may be used as an indicator of minoxidil response. A genetic test for alleles of the SULT1A1 gene may be performed to provide a more personalized therapy.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting anti-androgen therapy response in the treatment of androgenetic alopecia based on a fluorometric assay and proteomics.

Abstract: Switching circuits, latches and methods are provided, such as those that may respond to an input signal that transitions from a first binary level to a second binary level. One such switching circuit may have a metastable state that is closer to a first voltage corresponding to the first binary level than it is to a second voltage corresponding to the second binary level. In other embodiments, the metastable state may be dynamically adjustable so that it is at one voltage before the circuit switches and at a different voltage after the circuit switches. As a result, the switching circuit may respond relatively quickly to the input signal transitioning from the first binary level to the second binary level.

Abstract: A stool for supporting an adult and child includes a plurality of floor engaging legs extending substantially vertically and a seat mounted rigidly on the legs. The seat includes a main seating portion arranged horizontally and having a top surface for the adult to sit on and a bottom connected to at least some of the legs. The main seating portion has a rounded perimeter extending through an arc of at least 180°. The seat has a tongue portion integrally attached to the main seating portion and projecting horizontally from one side. The tongue portion has a top surface for the child to sit on and two opposite edges which taper inwardly towards an outer end. The adult and child are able to sit adjacent each other on the stool. In an exemplary version, the main seating portion has a minimum horizontal width of at least 35 cm.

Abstract: Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength range. Uses may include the treatment of such conditions as psoriasis, vitiligo, pruritus, acne, vitamin-D deficiency and atopic dermatitis. Topical creams, sprays, or other compositions may be used, with or without dosimeters, or in conjunction with an application, which calculates local UV exposure and other factors relating to dosage.

Abstract: A specific naturally occurring or genetically modified bacterial strain can be introduced into the hair follicle of patients suffering from androgenetic alopecia as to reduce the bioavailable extracellular testosterone and hence reduce the effect of androgens on the hair follicle.

Abstract: Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength. A fluorescent component may be included, which absorbs EMR at one wavelength and emits EMR at the desired wavelength. Uses may include the treatment of acne. Pruritus may also be treated by allowing the passage to the skin of a particular UV wavelength from sunlight, which has an immunosuppressive effect, while protecting the skin from other harmful UV radiation.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract: The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist.

Abstract: Methods and compositions are disclosed for administering electromagnetic radiation (EMR), for therapeutic or cosmetic purposes, or for purposes of curing a polymeric material.

Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting anti-androgen therapy response in the treatment of androgenetic alopecia based on a fluorometric assay and proteomics.

Abstract: A molding station and method comprising a hopper having a mouth closable with at least a lower door and a mold to be filled, the hopper and the mold being movable to a filling position in which the hopper is closed by the lower door; the lower door then opening to allow an amount of moldable material to be released into the mold; the mold being made in a deformable material, so that an interior volume of the mold is temporarily reduced when releasing the moldable material into the mold.

Abstract: A stool for supporting an adult and child includes a plurality of floor engaging legs extending substantially vertically and a seat mounted rigidly on the legs. The seat includes a main seating portion arranged horizontally and having a top surface for the adult to sit on and a bottom connected to at least some of the legs. The main seating portion has a rounded perimeter extending through an arc of at least 180°. The seat has a tongue portion integrally attached to the main seating portion and projecting horizontally from one side. The tongue portion has a top surface for the child to sit on and two opposite edges which taper inwardly towards an outer end. The adult and child are able to sit adjacent each other on the stool. In an exemplary version, the main seating portion has a minimum horizontal width of at least 35 cm.

Abstract: Switching circuits, latches and methods are provided, such as those that may respond to an input signal that transitions from a first binary level to a second binary level. One such switching circuit may have a metastable state that is closer to a first voltage corresponding to the first binary level than it is to a second voltage corresponding to the second binary level. In other embodiments, the metastable state may be dynamically adjustable so that it is at one voltage before the circuit switches and at a different voltage after the circuit switches. As a result, the switching circuit may respond relatively quickly to the input signal transitioning from the first binary level to the second binary level.

Abstract: A display assembly includes a transparent cover piece, a display shroud having a contact structure arranged to face the transparent cover piece, an interface subassembly mounted on the display shroud, an electronics board shroud having a support member and a connection feature, and a biasing member operably engaged between the display shroud and the electronics board shroud. The connection feature mechanically connects the electronics board shroud to the display shroud while permitting axial displacement and rotation therebetween. The biasing member rests on the support member of the electronics board shroud, and the biasing member is configured to urge the contact structure of the display shroud into physical contact with the transparent cover piece. The interface subassembly includes a display circuit for providing a digital display and a touch circuit for providing touch actuation at or near the digital display through the transparent cover piece.

Abstract: Switching circuits, latches and methods are provided, such as those that may respond to an input signal that transitions from a first binary level to a second binary level. One such switching circuit may have a metastable state that is closer to a first voltage corresponding to the first binary level than it is to a second voltage corresponding to the second binary level. In other embodiments, the metastable state may be dynamically adjustable so that it is at one voltage before the circuit switches and at a different voltage after the circuit switches. As a result, the switching circuit may respond relatively quickly to the input signal transitioning from the first binary level to the second binary level.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract: A novel, branched, saturated, primary fatty acid amide is disclosed. Application areas are as a slip and/or antiblocking agent or mould release agent. The branched, saturated, primary fatty acid has a formula R—CO—NH2 where R is a saturated, branched hydrocarbon chain having 11 to 23 carbon atoms, wherein at least 60% by weight of the R—CO—NH2 molecules have monoalkyl branches and less than 25% by weight of the R—CO—NH2 molecules have polyalkyl branches.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.