Abstract: A device for opening a sealed flexible packet and for dispensing its contents has a flexible body that allows a user to dispense a product from a sealed packet with the use of only one hand. The device has a body with a flexible a flexible outer wall defining a slot into which a user can place a sealed packet. The inner surface of the body has blades that pierce the packet when the body is squeezed around the packet. Further squeezing of the body causes the contents of the packet to be dispensed through openings in the body. The body is spring biased to a position to facilitate loading a packet, unloading the packet after dispensing the product, and replacing it with a sealed packet, all with the use of only one hand. Tabs at the end of the body help keep it upright during loading and unloading.

Abstract: An apparatus for separating a hydrocarbon content from a material matrix composes the hydrocarbon content and a water content, the apparatus comprising: a material feeder arranged to feed material through a treatment chamber, the treatment chamber comprising a window which is substantially transparent to microwaves; a microwave emitter arranged in use to expose feed material in the treatment chamber to microwaves via the window in order to cause rapid heating of at least part of the water content of the matrix to form steam, so as to remove at least part of the hydrocarbon content from the matrix; wherein the material feeder and treatment chamber are arranged so that in use, the treatment chamber is substantially tilted with material/matrix.

Abstract: Treatment targets such as tumors or lesions, located within an anatomical region that undergoes motion (which may be periodic with cycle P), are dynamically tracked. A 4D mathematical model is established for the non-rigid motion and deformation of the anatomical region, from a set of CT or other 3D images. The 4D mathematical model relates the 3D locations of part(s) of the anatomical region with the targets being tracked, as a function of the position in time within P. Using fiducial-less non-rigid image registration between pre-operative DRRs and intra-operative x-ray images, the absolute position of the target and/or other part(s) of the anatomical region is determined. The cycle P is determined using motion sensors such as surface markers. The radiation beams are delivered using: 1) the results of non-rigid image registration; 2) the 4D model; and 3) the position in time within P.

Abstract: A coin validator apparatus includes an inclined coin chute interconnecting the coin outlet gate with a coin rejection outlet via a validation sensor module and a coin diverter mechanism, the coin chute defining a coin transport path and including a radially outer curved guide wall, such that in operation a coin exiting the coin outlet gate and traversing the coin transport path is subjected to a centripetal acceleration that constrains the coin to follow and abut the contour of the radially outer curved guide wall between the coin outlet gate and a coin diverter sensor disposed downstream in the coin transport path.

Abstract: The film sealing and wrapping machine with a rotary cut and seal jaw is provided. The rotary cut and seal jaw has an internal sliding mechanism which provides for smooth and quiet operation. The rotational speed of the jaw may be varied to increase through put and to provide for a title bag around products. The rotary cut and seal jaw may comprise a seal bar and pressure pad may both be spring loaded to self align the seal bar and pressure pad during the sealing and cutting process. Lastly, a gap defined by a belt disposed upstream and downstream of the seal bar and pressure pad may be mechanically linked to the pressure pad through a control carriage.

Abstract: A plurality of different video transmissions may be sent over a network in a reduced definition mode which may be encoded on macroblock domains. The reduced definition video transmissions may be assembled into a composite having numerous thumbnails of reduced definition video transmissions on macroblock boundaries, without decoding the reduced definition video transmissions. These may be sorted and filtered and then combined into a single combined transmission (e.g., stream), which then may be decoded using, for example, a single decoder and displayed.

Abstract: A combined metrology mark, a system, and a method for calculating alignment on a semiconductor circuit are disclosed. The combined metrology mark may include a mask misregistration structure and a wafer overlay mark structure.

Abstract: A method for separating hydrocarbon content from a hydrocarbon contaminated matrix. The method includes controlling water content of a feed material having the hydrocarbon contaminated matrix; continuously conveying the feed material into a treatment cavity; exposing the feed material in a treatment area of the treatment cavity to microwave radiation arranged to cause rapid heating of at least a portion of the water content to form steam, wherein the rapid steam formation results in thermal desorption of at least a portion of the hydrocarbon content from the matrix; and continuously removing the treated matrix from the treatment cavity.

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

Abstract: The film sealing and wrapping machine with a rotary cut and seal jaw is provided. The rotary cut and seal jaw has an internal sliding mechanism which provides for smooth and quiet operation. The rotational speed of the jaw may be varied to increase through put and to provide for a title bag around products. The rotary cut and seal jaw may comprise a seal bar and pressure pad may both be spring loaded to self align the seal bar and pressure pad during the sealing and cutting process. Lastly, a gap defined by a belt disposed upstream and downstream of the seal bar and pressure pad may be mechanically linked to the pressure pad through a control carriage.

Abstract: A device for opening a sealed flexible packet and for dispensing its contents has a flexible body that allows a user to dispense a product from a sealed packet with the use of only one hand. The device has a body with a flexible a flexible outer wall defining a slot into which a user can place a sealed packet. The inner surface of the body has blades that pierce the packet when the body is squeezed around the packet. Further squeezing of the body causes the contents of the packet to be dispensed through openings in the body. The body is spring biased to a position to facilitate loading a packet, unloading the packet after dispensing the product, and replacing it with a sealed packet, all with the use of only one hand. Tabs at the end of the body help keep it upright during loading and unloading.

Abstract: The film sealing and wrapping machine with a rotary cut and seal jaw is provided. The rotary cut and seal jaw has an internal sliding mechanism which provides for smooth and quiet operation. The rotational speed of the jaw may be varied to increase through put and to provide for a title bag around products. The rotary cut and seal jaw may comprise a seal bar and pressure pad may both be spring loaded to self align the seal bar and pressure pad during the sealing and cutting process. Lastly, a gap defined by a belt disposed upstream and downstream of the seal bar and pressure pad may be mechanically linked to the pressure pad through a control carriage.

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

Abstract: A mounting assembly for holding a blade relative to a surface of a disc for a soil engaging apparatus, including: a first blade mount; and a blade; wherein the blade is mounted on the first blade mount such that the blade can move at least partially along the first blade mount and can tilt about an axis of the first blade mount.

Abstract: Disclosed is a method of forming on the surface of a substrate a first solid layer which is suitable for activating a chemical reaction to form a second layer thereon, the method comprising the steps of: applying to the surface of the substrate a first liquid comprising a curable composition and an activator for the second layer-forming chemical reaction; and curing the curable composition, thereby forming a first solid layer adhered to the surface of the substrate, capable of activating the second layer-forming chemical reaction. A second layer can then be formed on the substrate by bringing into contact with the first solid layer a second fluid comprising components of a second layer-forming chemical reaction, activated by the activator, thereby causing a second layer to be formed on the first solid layer.

Abstract: The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.

Abstract: Disclosed is a method of forming on the surface of a substrate a first solid layer which is suitable for activating a chemical reaction to form a second layer thereon, the method comprising the steps of: applying to the surface of the substrate a first liquid comprising a curable composition and an activator for the second layer-forming chemical reaction; and curing the curable composition, thereby forming a first solid layer adhered to the surface of the substrate, capable of activating the second layer-forming chemical reaction. A second layer can then be formed on the substrate by bringing into contact with the first solid layer a second fluid comprising components of a second layer-forming chemical reaction, activated by the activator, thereby causing a second layer to be formed on the first solid layer.

Abstract: A method of manufacturing a flexible composite panel having a plurality of reservoirs connected by at least one capillary includes forming a capillary assembly by winding a flexible, deformable capillary base web partially around a rotating cylinder that has a plurality of recessed features formed therein; drawing the capillary base web into the recessed features to form the capillaries in the capillary base web; filling the capillaries; and laminating a capillary barrier web over the capillary base web. A flexible reservoir assembly is formed by cutting the perimeter of the at least two reservoirs and associated catchments into a flexible reservoir web; removing the waste cut interiors of the reservoirs and the catchments from the reservoir web; securing the reservoir web to a base layer; overfilling each reservoir; and laminating the capillary assembly over the reservoir assembly, driving excess filler from the reservoirs into the catchments.

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

Abstract: Various methods and systems for creating or performing a dynamic sampling scheme for a process during which measurements are performed on wafers are provided. One method for creating a dynamic sampling scheme for a process during which measurements are performed on wafers includes performing the measurements on all of the wafers in at least one tot at all measurement spots on the wafers. The method also includes determining an optimal sampling scheme, an enhanced sampling scheme, a reduced sampling scheme, and thresholds for the dynamic sampling scheme for the process based on results of the measurements. The thresholds correspond to values of the measurements at which the optimal sampling scheme, the enhanced sampling scheme, and the reduced sampling scheme are to be used for the process.