Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating orexin-2 receptor activity and may be used in the treatment of disorders in which orexin-2 receptor activity is implicated, such as a neurodegenerative disorder, a symptom of a rare genetic disorder, a mental health disorder, a metabolic syndrome, osteoporosis, cardiac failure, coma, or a complication in emergence from anaesthesia.

Abstract: An improved finger splint includes an outer frame that partly surrounds an inner comfort sleeve. The outer frame is a substantially tubular shape with an oblong opening that cooperates with a patient's knuckle when the patient wears the splint around his finger and a pair of spine areas that extend along the underside of the patient's finger to encourage extension. The inner comfort sleeve includes a channel on its outer surface for receiving the outer frame, ridges along its inner surface, and holes and slots extending between its outer and inner surfaces to facilitate adjustment and breathability. Optionally, a fingertip guard can be removable attached to the inner sleeve with a series of protrusions that cooperate with the holes positioned around the inner sleeve. When assembled, the outer frame and inner comfort sleeve create a low profile, comfortable, and attractive and customizable splint.

Abstract: A multi-purpose truncated triangular pyramidal shaped cone is used as a sports field marker having a multi-sided shape with sides sloping at approximately 102.5° upward for the support of a smartphone with camera(s) leaning against a side to provide a stable view and record a timed finish of an athlete crossing a finish line of a race. The smartphone is secured to a side of the cone by an intermediate clamp holder having tapered resilient plugs pressed into receiving holes in the cone side. In an alternate use, plural cones are used to hold ends of a horizontal hurdle bar. This bar is raised higher by stacking identical hollow cones forming a stack with a long pole extending through a hole in a flat top surface of a top truncated cone. The pole is secured along a vertical axis of the cone stack by set screws converging along their axes from holes on each side of the pyramidal cone. A bowed cradle is mounted atop the pole to hold the horizontal hurdle bar.

Abstract: An adapter for removably coupling a tracker to a surgical handpiece includes a proximal member having an interface configured to engage and prevent rotation of the proximal member relative to the surgical handpiece, a distal member slidably and rotatably coupled to the proximal member, a biasing member disposed between the proximal distal members and configured to urge the proximal and distal members in opposing directions, and a tracking array mount coupled to the distal member. The biasing member is configured to be compressed by a reference feature of the end effector and the surgical handpiece when the distal member is disposed on the end effector and the end effector is coupled to the surgical handpiece, the compressed biasing member creating a frictional force between the distal and proximal members that resists rotation of the distal member relative to the proximal member.

Abstract: An interchangeable electro-mechanical lock core for use with a lock device having a locked state and an unlocked state is disclosed. The interchangeable electro-mechanical lock core may include a moveable plug having a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which corresponds to the lock device being in the unlocked state. The interchangeable electro-mechanical lock core may include a core keeper moveably coupled to a lock core body. The core keeper may be positionable in a retain position wherein the core keeper extends beyond an envelope of lock core body to hold the lock core body in an opening of the lock device and a remove position wherein the core keeper is retracted relative to retain position to permit removal.

Abstract: A fitting system for an earpiece that comprises a support structure that is configured to contact at least one of the ear canal or the concha of an ear of a user, including at least first and second spaced electrodes that are each configured to contact the user's skin, circuitry that is configured to determine an impedance between the first and second electrodes, and a controller, responsive to the determined impedance, for causing the earpiece support structure to move.

Abstract: A covert sports communication system has a transmitter configured to wirelessly transmit coded audio track selection signals. The system includes a receiver that may be worn within headgear. The receiver includes stored audio tracks and is configured to receive coded audio track selection signals from the transmitter, decode the audio track selection signals, and play at least one stored audio track in accordance with the decoded audio track selection signals. The audio tracks may include audio instructions to a participant of a sporting event.

Abstract: The invention described herein relates to compounds of Formula (1b): or a salt thereof, wherein R1, R1a, R2, R3 and R5 are defined herein, and their use in the treatment of SARS-CoV-2 and related viruses and disorders associated with SARS-CoV-2.

Abstract: A baseball pitch selection communication system has a transmitter and a body-worn visual receiver. The transmitter includes a transmitter unit configured to transmit wireless signals, a first microcontroller and a plurality of user actuatable input elements. The first microcontroller is configured to provide the transmitter unit with a selection signal to wirelessly transmit in accordance with actuation of the user actuatable input elements, the selection signal corresponding to a pitch selection. The visual receiver includes a receiving unit configured to wirelessly receive the selection signal, a memory configured to contain a plurality of stored visual instructions, a display configured to display visual instructions, and a second microcontroller. The second microcontroller is configured to control the memory and the display to display a selected visual instruction in accordance with the received selection signal, where the selected visual instruction corresponds to the pitch selection.

Abstract: A cooling system configured to remove heat from a chimney of a server cabinet. The cooling system including a first chimney portion adjacent to the server cabinet, a second chimney portion extending from a top of the first chimney portion, wherein the second chimney portion is disposed above the server cabinet, a chimney heat exchanger disposed in the second chimney portion and above the server cabinet, a fluid inlet for providing a working fluid to the chimney heat exchanger, a fluid outlet for discharging the working fluid from the chimney heat exchanger, and an air handler heat exchanger connected to the chimney heat exchanger by a return air plenum, wherein the chimney heat exchanger has an upstream surface that receives waste heat generated by a server disposed in the server cabinet and a downstream surface that discharges air to the return air plenum.

Abstract: Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides.

Abstract: Systems, methods, and devices for operating an integrated telehealth platform are disclosed herein. In some embodiments, the integrated telehealth platform provides telehealth kits and associated services and sessions, such as diagnostic testing, temperature measurement, and drug screening, to users. The platform can guide the user through the steps of performing such sessions. The platform can analyze the session results, such as a thermometer reading, and/or coordinate delivery of the telehealth kit to a laboratory for further analysis. Based on the analysis result, the platform can provide microbenefits to the user in the form of, for example, discounted or free medication. The platform can communicate with users, proctors, providers, pharmacies, and other entities. The platform can also unlock or lock vehicles based on a drug screening test performed by a potential vehicle operator prior to operation of the vehicle.

Abstract: A container for transporting and storing liquid, viscous or pourable substances, in particular a container of the Intermediate Bulk Container type. The container has a base, a side wall, and at least one outlet recess in the base and/or the side wall, in which an outlet valve is or can be arranged and which is closable on the outside of the container by a cover. The cover has a base section, by which the cover is fastened or fastenable to the container, and a closure section which is hinged on the base section via a hinge assembly such that it can pivot about a rotational axis. The hinge assembly can hold or lock the closure section in a self-supporting manner in a position releasing the outlet recess.

Abstract: One example method for managing participants in video conferences includes generating, by a video conferencing server, a request for a response status for each of a plurality of invitations to a video conference, each of the plurality of invitations associated with a video conference attendee, transmitting the request to a video conferencing application executed by a client device, receiving, by the video conferencing server, the response status for each of the plurality of invitations to the video conference, initiating, by the video conference server, the video conference, generating, by the video conference server, a list of each video conference attendee and the response status for each of the plurality of invitations to the video conference, and transmitting, by the video conferencing server, the list of each video conference attendee and the response status to the video conferencing application on the client device.

Abstract: A multi-directional expandable modular agility exercise ladder has spaced rows of two part paired rungs having overlapping ends joined to each by a pivot post forming a variable angle chevron prow. Outer ends of the paired rungs are interlocked to two parallel spaced bands to complete the ladder. A hook and loop pad interlock is used. Alternately, spaced key holes extend through the bands with the outer ends of the rungs having downwardly extending retainer poles secured in a respective key hole. Alternately, releasable spring clamps hand movable along the band length secure rung ends to the bands.

Abstract: Systems and methods for providing remotely proctored at-home health testing and diagnostics are provided herein. In particular, systems and methods for improving proctor performance by increasing accuracy and reducing proctor time are disclosed. In some embodiments, images and/or video of a patient may be enhanced to aid the proctor. In some embodiments, proctor performance may be evaluated. In some embodiments, proctor time per patient may be reduced by automating one or more steps in a proctored testing process.

Abstract: Examples described herein relate to a network interface device comprising a multi-stage programmable packet processing pipeline circuitry to determine a path to transmit a packet based on relative network traffic transmitted via multiple paths. In some examples, determine a path to transmit a packet is based on Deficit Round Robin (DRR). In some examples, the programmable packet processing pipeline circuitry includes: a first stage to manage two or more paths, wherein a path of the two or more paths of the first stage is associated with two or more child nodes, a second stage to manage two or more paths, wherein a path of the two or more paths of the second stage is associated with two or more child nodes, and at least one child node is associated with the determined path.

Abstract: Methods for loading a module on a plurality of device types without modification includes initializing an application native to the client device, the application including a web browser; determining a module to be loaded on the application, the module written in a web-based format and having a set of dependencies indicated within a code thereof; and loading the determined module on the web browser for recognition by the application native to the client device. The loading the determined module on the web browser includes loading the set of dependencies of the module.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: The present invention is directed to an agricultural composition comprising a protoporphyrinogen oxidase (PPO) inhibitor, one or more sugar alcohols and optionally, one or more auxin herbicides. The present invention is further directed to a method of controlling weeds comprising applying concurrently or sequentially a PPO inhibitor and one or more sugar alcohols, and optionally one or more auxin herbicides to the weeds or an area in need of weed control.