Abstract: The present disclosure generally relates to a lock including a blocker (e.g., a bolt) useable to selectively prevent access through a portal such as a door. The blocker can be retained in a blocking position to prevent access through the portal by a retainer. In alternative embodiments, the blocker can also be retained in an open position to allow access through the portal. A retainer can be utilized to retain the blocker in the blocking position preventing access through the portal and can also be utilized, in certain embodiments, to retain the blocker in the open position to allow access through the portal. A retainer blocker can be utilized to maintain the retainer in position to retain the blocker (e.g., bolt) in a fixed position. An actuator may, in certain alternative embodiments, be employed to position the retainer blocker. In certain embodiments, the actuator is controlled by an electronic controller.

Abstract: A system for remotely communicating sports instructions that includes a transmitter and an audio receiver. The transmitter includes a transmitter unit configured to transmit wireless signals, a first microcontroller coupled to the transmitter unit, the first microcontroller configured to provide the transmitter unit with a selection signal to wirelessly transmit, and a display screen with plurality of user actuatable input elements coupled to the transmitter unit. The user actuatable input elements respectively correspond to different sports instructions. The first microcontroller is configured to provide the transmitter unit with the selection signal to wirelessly transmit a prewritten text in accordance with actuation of the user actuatable input elements, the selection signal corresponding to a sports instruction.

Abstract: Provided herein are compositions and methods for detecting the binding of a peptide to an MHC molecule, and the binding of a peptide:MHC complex to a TCR. In preferred embodiments, the compositions and methods are in a highly-multiplexed way. The compositions and methods disclosed herein can be used to provide direct information on which peptides are bound to an MHC molecule. Also provided is a method for simultaneously detecting a large number of peptides for binding to an MHC molecule and/or a T cell. A method for detecting competitive binding of a large number of peptides to an MHC molecule and/or a T cell is also disclosed. Also provided herein is a method for simultaneously detecting a large number of specific TCRs. The compositions and methods of the present invention are useful for vaccine design, research and monitoring of autoimmune and infectious disease, immunogenicity testing of therapeutics, and tissue typing.

Abstract: An interchangeable electro-mechanical lock core for use with a lock device having a locked state and an unlocked state is disclosed. The interchangeable electro-mechanical lock core may include a moveable plug having a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which corresponds to the lock device being in the unlocked state. The interchangeable electro-mechanical lock core may include a core keeper moveably coupled to a lock core body. The core keeper may be positionable in a retain position wherein the core keeper extends beyond an envelope of lock core body to hold the lock core body in an opening of the lock device and a remove position wherein the core keeper is retracted relative to the envelope of the lock core body to permit removal.

Abstract: An apparatus includes a housing that defines a fluid reservoir and includes a port that is in fluid communication with the fluid reservoir. An inlet adapter is removably coupleable to the housing. A user can engage an actuator to move a plunger from a first position in which the fluid reservoir has a first volume, to a second position in which the fluid reservoir has a second volume greater than the first volume, which draws bodily fluid into the fluid reservoir via the inlet adapter. The actuator modulates a plunger rate of motion below a threshold as the plunger is moved. When a predetermined volume of bodily fluid is transferred into the fluid reservoir, a volume indicator transitions from a first state to a second state and the inlet adapter can then be removed to transfer the predetermined volume into a sample bottle external to the housing via the port.

Abstract: Apparatuses, systems, and methods for brewing a desired portion of a beverage, such as a single-cup portion of coffee, are provided. The system can include one or more hopper assemblies configured to provide a controlled dose of beverage material to a brew chamber. The system can also include a water input system configured to wet the ground beverage material as the grinds enter the brew chamber and substantially prevent steam from reaching grinder components of the system. Further, the system can include an automatic cleaning mechanism such that a user does not need to manually clean components of a brewing machine between brew cycles.

Abstract: A system including a point of load converter module (POL). The POL module includes a point of load printed circuit board. At least one inductor is mounted to the point of load printed circuit board. The POL module includes a power network. The point of load converter module is configured to be surface mounted. The system includes a heat sink including a first leg configured to be surface mounted adjacent the point of load printed circuit board, a second leg configured to be surface mounted adjacent the point of load printed circuit board opposite the first leg, and a cap portion connecting the first leg to the second leg. The heat sink is sized and shaped to encompass the POL and configured to connect to the power network. The power network may be a PGND network.

Abstract: A workstation is described for mounting specimens into a cryotransfer holder at cryogenic temperature. The workstation allows rotation about the cryotransfer holder axis to improve access to the sample placement area on the holder and to facilitate easy removal and retrieval of the sample after imaging. The cryotransfer holder includes a cylindrical dewar configured to maintain a constant center of mass about the holder axis regardless of orientation of the dewar.

Abstract: A container includes a base; side walls extending upwards from an upper face of the base; and at least one support plate which is spaced apart from a lower face of the base and is connected to the lower face of the base by ribs extending transversely to the base and transversely to the at least one support plate. At least two laterally protruding projections are formed at least on an edge portion of the support plate extending along one of the side walls. At least two support recesses for receiving at least two projections of a support plate of an identical container stacked thereon are formed in the upper edge portion of the at least one side wall.

Abstract: Implementations of the present disclosure generally relate to an apparatus for large-scale external pressure storage, and more particularly for large-scale storage of liquid hydrogen and other products that require evacuated insulation. In some examples, a plate for a storage apparatus is provided. The plate a body that includes a beveled joint with the body having a nominal thickness at the beveled joint. The beveled joint is configured to be welded to a corresponding beveled joint of an adjacent plate.

Abstract: A beverage pad (100) for use in a beverage preparation machine for preparing a beverage comprises an amount of extractable and/or soluble beverage preparation product in a compacted puck (130) enclosed between two sheets of filtering material (110, 120) sealed to each other at a periphery edge of the pad. A first sheet of the two sheets has a bottom portion, side portion and a first edge portion. A second sheet of the two sheets comprises a central portion and a second edge portion. The edge portions of the sheets are sealed to each other forming the periphery edge of the pad. The side portion, bottom portion and central portion define a space holding the compacted puck (130) of extractable and/or soluble beverage preparation product which has a uniform thickness.

Abstract: Various aspects include wearable devices and related approaches for stimulating nerves proximate a user's ear, e.g., providing one or more health benefits. In some particular aspects, a wearable device for providing vibrotactile stimulus to at least one nerve proximate an ear of a user includes: an earpiece having a vibration device for application of vibrotactile stimulus proximate at least one of a concha region or an ear canal of the user; and a controller connected with the vibration device, the controller configured to actuate the vibration device according to a modulated pattern to stimulate at least one nerve proximate the ear of the user, where the modulated pattern is characterized by: a peak drive level sufficient to stimulate nerve endings of at least one nerve proximate the ear of the user; and a carrier frequency of approximately 50 Hertz (Hz) to approximately 500 Hz.

Abstract: A covert sports communication system has a transmitter configured to wirelessly transmit coded audio track selection signals. The system includes a receiver that may be worn within headgear. The receiver includes stored audio tracks and is configured to receive coded audio track selection signals from the transmitter, decode the audio track selection signals, and play at least one stored audio track in accordance with the decoded audio track selection signals. The audio tracks may include audio instructions to a participant of a sporting event.

Abstract: A current transformer assembly includes a first current transformer, a plug, a first wire and a second wire between the plug and the first current transformer adapted to transmit a measurement of the first current transformer; and a memory chip adapted to store a first scale factor of the first current transformer.

Abstract: Interchangeable primary massage heads for therapeutic treatment of body regions are mounted on secondary massage heads partially fitting inside of the primary massage heads. The secondary heads are fixed at proximal ends of intermediate mounting shafts in turn having distal ends fitting in or over drive shafts of percussive massage guns. Either primary or secondary massage head may be shaped as a bullet, disc, ball, spade, scraper, paddle or flexible net. A different embodiment is an adapter converter shaft formed as a secondary massage head shaped as a truncated conical cone with a center top hole sized to receive an intermediate mounting shaft on which a primary massage head is inserted. The adapter shaft has a distal end adapted to slip over short stroke drive shafts of compact massage guns enabling primary massage heads usage with either bigger or compact massage guns.

Abstract: A network element includes a port; and a device with circuitry configured to encode data for communication to a second device via a plurality of physical channels, and utilize one of the plurality of physical channels as a dedicated timing channel with encoding thereon different from encoding on the other plurality of physical channels, and interface encoded data via the plurality of physical channels with the port for transmission and reception with a second device.

Abstract: Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides.

Abstract: Various examples are directed to systems and methods for interfacing a computing system to a human user. For example, a computing system may provide a graphical user interface at a display of a user computing device. The user interface may include a positive financial profile indicator at a first position on the display; a negative financial profile indicator at a second position on the display opposite the positive financial profile indicator; and a user financial profile indicator describing a user, the user financial profile indicator positioned between the positive financial profile indicator and the negative financial profile indicator. The computing system may receive user transaction data describing a financial transaction. The computing system may determine that the financial transaction worsens a financial profile of the user. The computing system may also modify the user interface to orient the user financial profile indicator towards the negative financial profile indicator.

Abstract: A method and system for determining or predicting the most commonly billed supplementary codes or medical services for each unique primary CPT code or service by identifying patterns between co-occurring billed supplementary services in historical claims data. The accuracy of the predictions is scored by applying a similarity index, and an accuracy score is provided for each prediction.

Abstract: Systems, methods, and devices associated with the precise manipulation and placement of virtual content/objects in virtual space are disclosed herein. In some embodiments, user input data associated with placement of virtual content in a virtual space can be filtered/transformed across one or more degrees of freedom of the coordinate system associated with the virtual space. The filters/transforms may add precision to placement of the virtual content. The user input data can continually be monitored to detect an indication that the virtual content is close to a target location/orientation in the virtual space, and filters/transforms may be adjusted or applied to provide the user with additional precision and control over placement of the virtual content.