Abstract: A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units.

Abstract: An equipment mounting system for mounting equipment to a support structure is described. An equipment mounting system including: (i) a mounting plate having defined therein a plate aperture of a particular shape; (ii) a bolt having a shaft portion including a threaded portion and a non-threaded portion that is of a complementary shape that complements the particular shape of the plate aperture; and (iii) a washer having defined therein a scored aperture that includes multiple radially extending scorings. In an assembled configuration of the mounting plate, the bolt and the washer, the plate aperture of the particular shape aligns with the scoring aperture such that both of the plate aperture and the scoring aperture receive the non-threaded portion of the complementary shape, and the particular shape of the mounting plate engages with the complementary shape of the bolt to prevent rotational displacement of the bolt around the mounting plate.

Abstract: An insulated wire or cable is made by a process comprising the steps of: (A) extruding onto a covered or uncovered metal conductor or optical fiber a composition having a DF measured at 130° C. (60 Hz, 2 kV) or 120° C. (60 Hz, 8 kV) or 100° C. (60 Hz, 8 kV) of ?0.5% and comprising: (1) a high melt strength ethylene-based polymer made in a tubular reactor, and (2) a peroxide, and (B) crosslinking the high melt strength ethylene-based polymer.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4f, X1, X2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R4f, R5, R6 have the meaning as indicated in the description and claims The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: Systems and methods for generating three-dimensional models with correlated three-dimensional and two dimensional imagery data are provided. In particular, imagery data can be captured in two dimensions and three dimensions. Imagery data can be transformed into models. Two-dimensional data and three-dimensional data can be correlated within models. Two-dimensional data can be selected for display within a three-dimensional model. Modifications can be made to the three-dimensional model and can be displayed within a three-dimensional model or within two-dimensional data. Models can transition between two dimensional imagery data and three dimensional imagery data.

Abstract: A network element includes at least two Time Division Multiplexing (TDM) modules each including a TDM client interface, TDM processing circuitry, and circuit emulation circuitry; and a packet switch fabric connected to the at least two TDM modules in a Link Aggregation Group (LAG) for a protected TDM service, and configured to output a packet interface, wherein the protected TDM service is provided as a single packetized TDM stream via the packet interface from the packet switch fabric.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present invention relates to a support structure for supporting a top structure, in particular a wind turbine, above the ground or a seabed, the support structure comprising: one single support pile having a length and a first outer diameter, the one single support pile comprising an upper part configured and intended to extend above the ground or the seabed, wherein the upper part of the support pile is configured to be connected to the top structure; a lower part configured to be in contact with the ground or seabed, wherein the support pile is configured to exert an upward vertical force on the top structure in order to carry the top structure; a plurality of foundation guides connected to the lower part of the single support pile, each foundation guide having an opening extending in a direction of the support pile.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra4, Ra5, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: A radiotherapy device is disclosed. The radiotherapy device includes a radiation source, a detecting means and controller communicatively coupled to the radiation source and the detecting means. The radiation source is configured to generate a treatment beam for irradiating a subject. The detecting means is configured to detect a motion of the subject, the motion comprising a first physiological motion component and a second physiological motion component.

Abstract: Systems and methods for generating three-dimensional models with correlated three-dimensional and two dimensional imagery data are provided. In particular, imagery data can be captured in two dimensions and three dimensions. Imagery data can be transformed into models. Two-dimensional data and three-dimensional data can be correlated within models. Two-dimensional data can be selected for display within a three-dimensional model. Modifications can be made to the three-dimensional model and can be displayed within a three-dimensional model or within two-dimensional data. Models can transition between two dimensional imagery data and three dimensional imagery data.

Abstract: A biopharmaceutical flow port, a biopharmaceutical liquid container assembly, and a method for manufacturing the biopharmaceutical flow port and the biopharmaceutical liquid container assembly are described. The biopharmaceutical flow port includes a hose barb coupled to an elliptic body. The hose barb includes a bore. The elliptic body includes a flow passage, a first edge, and a second edge. The flow passage is fluidly coupled to the bore. The first edge extends from the elliptic body away from the flow passage in a first direction and the second edge extends from the elliptic body away from the flow passage in a second direction opposite the first direction. The biopharmaceutical liquid container assembly includes a biopharmaceutical liquid container with an opening and the biopharmaceutical flow port coupled to the biopharmaceutical liquid container within the opening and in fluid communication with a volume of the biopharmaceutical liquid container.

Abstract: The present invention relates to methods of manufacture for producing a drug substance (DS) or drug product (DP) comprising a mammalian anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO: 36 and a light chain (LC) comprising SEQ ID NO: 37.

Abstract: A set of tools for prying and removing virtually all vehicle trim and upholstery items includes a sharp curve trim removal tool having an elongate cylindrical rod with a scalloped, scoop-shaped distal end and a pocket clip, a defined fulcrum trim and upholstery removal tool having a flat bar having a rectilinear handle segment extending from the tool proximal end to a middle segment, and a curved tool distal end defining a rounded corner functioning as an acute upturned fulcrum curve along a tool lower surface, giving the user added mechanical advantage. The bar tapers to a sharp edge at the distal end. The set further includes a clip removal tool which is the same as the trim and upholstery removal tool except that it additionally includes a central notch in the sharp edge at the distal end for clip engagement.

Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

Abstract: Continuous processes for the manufacture of porous carbon materials are disclosed. The process includes the reaction of a self-assembling polymeric mixture, followed by drying and extrusion of the cured, semi-dry polymeric gel extrudate prior to pyrolysis. Also disclosed are porous carbon materials, such as porous carbon monoliths, produced by these processes. In particular, hierarchically porous carbon materials for use as a catalyst support or for the adsorption of gas and other substances that are manufactured by these processes are also disclosed.

Abstract: The present invention relates to a breath tester. The breath tester includes a sensor for sensing a mind-altering substance in breath from a blower (i.e., person blowing and providing a sample). A breath guide is provided for guiding the breath so that it is not returned to the blower. Advantageously, the guide guides the breath so that it is not returned to the blower to thereby minimise the likelihood of spread of infectious disease.