Patents by Inventor John Brown

John Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-MEMBRANE DISRUPTIVE P53 ACTIVATING STAPLED PEPTIDES
    Publication number: 20180030090
    Abstract: The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of these peptides. In one embodiment, the peptide comprises or consist of the amino acid sequence of TSFXaa1EYWXaa3LLXaa2, where Xaa1 is (R)-2-(7?-octenyl)alanine or derivative thereof, or is (R)-2-(4?-pentenyl)alanine or derivative thereof; and Xaa2 and Xaa3 are independently any type of amino acid or modified amino acid. In another embodiment, the peptide comprising or consisting of the amino acid sequence of TSFXaa1EYW Xaa3LLXaa2ENXaa5, wherein Xaa1 and Xaa3 are any type of amino acid or modified amino acid; Xaa2 is S, or P, or (S)-2-(4?-pentenyl)alanine or a derivative of (S)-2-(4?-pentenyl)alanine; and wherein Xaa5 is F or Y.
    Type: Application
    Filed: February 15, 2016
    Publication date: February 1, 2018
    Inventors: Yaw Sing TAN, Christopher John BROWN, Chandra S. VERMA, Fernando Jose FERRER GAGO, David P. LANE, Thomas JOSEPH
  • CENTER BEARING ASSEMBLY WITH SHEAR MEMBER
    Publication number: 20180031043
    Abstract: A center-bearing assembly includes an annular housing having a circumferential wall with a lip extending radially inward and includes a flange outboard of the circumferential wall. A roller bearing is sized to encircle a vehicle driveshaft and is disposed within the housing between the lip and the flange. An annular retainer is connected to the flange and includes an annular notch configured to shear in response to impact to the driveshaft allowing the bearing to release from the housing.
    Type: Application
    Filed: July 26, 2016
    Publication date: February 1, 2018
    Inventors: Chris Peter NICHOLAS, Brian John BROWN, Duane Allan LEWIS, Bradley W. DONER, Edward Steven LANIVICH, Rakesh SHARMA
  • Center bearing assembly with shear member
    Patent number: 9879728
    Abstract: A center-bearing assembly includes an annular housing having a circumferential wall with a lip extending radially inward and includes a flange outboard of the circumferential wall. A roller bearing is sized to encircle a vehicle driveshaft and is disposed within the housing between the lip and the flange. An annular retainer is connected to the flange and includes an annular notch configured to shear in response to impact to the driveshaft allowing the bearing to release from the housing.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: January 30, 2018
    Assignee: Ford Global Technologies, LLC
    Inventors: Chris Peter Nicholas, Brian John Brown, Duane Allan Lewis, Bradley W. Doner, Edward Steven Lanivich, Rakesh Sharma
  • OPTIMIZED AGITATOR SYSTEM FOR PRODUCTION OF POLYOLEFIN
    Publication number: 20170361301
    Abstract: The various embodiments of the present invention relate to a polymerization reactor where the agitator mixing performance is optimized for use with a high activity catalyst and methods for developing the same.
    Type: Application
    Filed: January 4, 2016
    Publication date: December 21, 2017
    Applicant: NOVA Chemicals (International) S.A.
    Inventors: Yves Lacombe, Eric Clavelle, Stephen Salomons, Andrew Hawriuk, Stephen John Brown, Marion Walls
  • Lighting device and light panel construction
    Patent number: 9845940
    Abstract: A lighting device (10) having a base housing (12) to receive one or more batteries therein to power a light source located in a light housing (14). The light housing (14) being pivotally attached to the base housing (12) at pivot points on both sides of the base housing (12), wherein a handle (24) is provided which extends along the axis of rotation (13) between the pivot points.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: December 19, 2017
    Assignee: Energizer Brands, LLC
    Inventors: Timothy Rugendyke, Angelo Kotsis, John Brown, Michael Squires
  • Compounds
    Patent number: 9834560
    Abstract: The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 5, 2017
    Assignee: Respivert Ltd.
    Inventors: John King-Underwood, Kazuhiro Ito, Peter John Murray, George Hardy, Frederick Arthur Brookfield, Christopher John Brown
  • FREE-STANDING WALL ARRANGEMENT AND METHODS
    Publication number: 20170292264
    Abstract: A free-standing wall includes concrete base blocks adjacent to each other forming a base course; a first set of concrete wall blocks stacked on the base course and on each other to form a first wall face; and a second set of concrete wall blocks stacked on the base course and on each other to form a second wall face that faces the opposite direction from the first wall face and that has the same number of courses as the first plurality of wall blocks. Methods of constructing the wall arrangement include laying the base blocks next to each other end to end; stacking individual blocks of a first set of blocks on the base course and then on each other to form a first wall face; stacking individual blocks of the second set of blocks on the base course and then on each other to form a second wall face that faces a direction opposite of the first wall face.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 12, 2017
    Inventors: Robert Joel Wolter, Robert B. Burnquist, Harrison John Brown, Dale A. Buker, Jay J. Johnson
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170292150
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 12, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Derek Alexander Weddell, Daryl Simon Walter, Paul Richard Giles, Ian James Wigginton, Malcolm George Taylor, Sébastien René Gabriel Galan, Peter David Johnson, Thomas Martin Krülle, Inaki Morao, Daniel Clark-Frew
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170281804
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Thomas Martin Krülle, Daniel Clark-Frew, Sarah Hayes
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170283439
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Applicant: CCHDI Foundation Inc.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Daniel CLark-Frew
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20170283436
    Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 28, 2015
    Publication date: October 5, 2017
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Sébastien René Gabriel Galan, Michael Edward Prime, Paul Richard Giles, Elise Luciennen Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, Peter David Johnson, Samuel Coe, Sarah Hayes
  • SEAL ASSEMBLY TO SEAL CORNER LEAKS IN GAS TURBINE
    Publication number: 20170284214
    Abstract: Various embodiments include gas turbine seals and methods of forming such seals. In some cases, a turbine includes: a first arcuate component adjacent to a second arcuate component, each arcuate component including one or more slots located in an end face, each of the one or more slots having a plurality of axial surfaces and radially facing surfaces extending from opposite ends of the axial surfaces and a seal assembly disposed in the slot. The seal assembly including a backup intersegment seal disposed in the slot on a high-pressure side of the slot and a shim seal disposed in the slot over the backup intersegment seal and covering the backup intersegment seal on a low-pressure side of the slot. The shim seal including one or more shim seal segments and having a gap formed between each of the one or more shim seal segments.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Inventors: Jason Edward Albert, Bodhayan Dev, Neelesh Nandkumar Sarawate, Michael John Brown
  • Free-standing wall arrangement and methods
    Patent number: 9745743
    Abstract: A free-standing wall includes concrete base blocks adjacent to each other forming a base course; a first set of concrete wall blocks stacked on the base course and on each other to form a first wall face; and a second set of concrete wall blocks stacked on the base course and on each other to form a second wall face that faces the opposite direction from the first wall face and that has the same number of courses as the first plurality of wall blocks. Methods of constructing the wall arrangement include laying the base blocks next to each other end to end; stacking individual blocks of a first set of blocks on the base course and then on each other to form a first wall face; stacking individual blocks of the second set of blocks on the base course and then on each other to form a second wall face that faces a direction opposite of the first wall face.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: August 29, 2017
    Assignee: Anchor Wall Systems, Inc.
    Inventors: Robert Joel Wolter, Robert B. Burnquist, Harrison John Brown, Dale A. Buker, Jay J. Johnson
  • Methods for making free fatty acids from soaps using thermal hydrolysis followed by acidification
    Patent number: 9745541
    Abstract: Provided are methods, processes and systems for treating a soapstock. In alternative embodiments, provided are systems and methods for treating a soapstock to generate free fatty acids and/or fatty acid derivatives, e.g. fatty acid alkyl esters. In alternative embodiments, provided are systems and methods for realizing the full fatty acid yield of a soapstock by first converting substantially all of the saponifiable material in a soapstock to salts of fatty acids (soaps) and acidulating the soaps to generate free fatty acids and/or fatty acid derivatives, e.g. fatty acid alkyl esters, wherein the soapstock comprises soaps and saponifiable lipids, e.g. glycerides and/or phospholipids, and the generating of free fatty acids and/or fatty acid is achieved.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 29, 2017
    Assignee: INVENTURE RENEWABLES, INC.
    Inventors: William Rusty Sutterlin, Ryan Alexander Long, Cory Oneil Blanchard, John Brown
  • Assembly and process for creating an extruded pipe for use in a geothermal heat recovery operation
    Patent number: 9744710
    Abstract: An assembly and process for forming a two stage extruded pipe having a central inner sleeve and a pair of outer attached lobes. The central sleeve shaped (also termed a grout receiving tube) is produced in an initial extrusion operation, following which it enters a cross head operation where a pair of outer lobes are attached to cross sectional exterior surface locations according to a second stage extrusion operation so as to be integrally formed therewith. Other steps include cooling of the dual stage extruded pipe, as well as sectioning and stacking the pipe. Additional steps include forming elongated slots or apertures into the central sleeve portion of the finished extrusion, such in non-interfering fashion with the individual passageway defining and lobes.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: August 29, 2017
    Assignee: U.S. Farathane Corporation
    Inventors: Steve Porter, Timothy John Brown
  • QUINAZOLIN-4 (3H)-ONE DERIVATIVES USED AS P13 KINASE INHIBITORS
    Publication number: 20170202841
    Abstract: The present invention relates to the compound of formula (I) and to compositions comprising the same and to the use of the compound and to compositions of the compound in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compound.
    Type: Application
    Filed: March 30, 2017
    Publication date: July 20, 2017
    Applicant: Respivert Limited
    Inventors: John King-Underwood, Kazuhiro Ito, Peter John Murray, George Hardy, Frederick Arthur Brookfield, Christopher John Brown
  • Radiotherapy and imaging apparatus
    Patent number: 9694205
    Abstract: Radiotherapy apparatus comprises a source of radiation mounted on a chassis, that is rotatable about a rotation axis and the source being adapted to emit a beam of radiation along a beam axis; a patient support, moveable along a translation axis; a set of magnetic coils located on either side of the beam, for establishing a magnetic field along a first direction; the translation axis, the rotation axis, and the first direction being substantially parallel; and further comprising a multi-leaf collimator fixed in its orientation with respect to the source of radiation, the multi-leaf collimator comprising a plurality of elongate leaves disposed with their longitudinal directions substantially aligned with the first direction and movable in that direction between a withdrawn position in which the leaf lies outside the beam, an extended position in which the leaf projects across the beam.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: July 4, 2017
    Assignee: ELEKTA AB (PUBL)
    Inventors: John Allen, Duncan Neil Bourne, Kevin John Brown
  • Continuous ethylene tetramerization process
    Patent number: 9688588
    Abstract: A continuous flow process for the oligomerization of ethylene using a chromium catalyst having a phosphorus-nitrogen-phosphorus (“P—N—P”) ligand provides high selectivity to the desired tetramer (1-octene) with reduced production of coproduct C10+ oligomers. Prior art processes that maximize catalyst activity have provided comparatively poor product selectivity. In particular, the production of larger amounts of C10+ oligomers have been observed under conditions that maximize activity. The present process resolves this problem through the use of a combination of low catalyst concentration and by limiting the octene concentration in the reactor.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: June 27, 2017
    Assignee: NOVA Chemicals (International) S.A.
    Inventors: Peter Zoricak, Stephen John Brown, P Scott Chisholm
  • ASSEMBLY FOR CREATING AN EXTRUDED PIPE FOR USE IN A GEOTHERMAL HEAT RECOVERY OPERATION
    Publication number: 20170157827
    Abstract: An assembly and process for forming a two stage extruded pipe having a central inner sleeve and a pair of outer attached lobes. The central sleeve shaped (also termed a grout receiving tube) is produced in an initial extrusion operation, following which it enters a cross head operation where a pair of outer lobes are attached to cross sectional exterior surface locations according to a second stage extrusion operation so as to be integrally formed therewith. Other steps include cooling of the dual stage extruded pipe, as well as sectioning and stacking the pipe. Additional steps include forming elongated slots or apertures into the central sleeve portion of the finished extrusion, such in non-interfering fashion with the individual passageway defining and lobes.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Inventors: Steve Porter, Timothy John Brown
  • Method and apparatus for assembling a driveshaft flange to a transmission flange
    Patent number: 9657782
    Abstract: A drivetrain assembly includes a transmission and a driveshaft that are joined together by a transmission flange and a driveshaft flange that has a plurality of pre-assembled bolts. The driveshaft flange defines a plurality of holes and countersink recesses and the bolts are secured to the driveshaft flange by a bolt retainer disposed in each of the countersink recesses between the transmission flange and the driveshaft flange. A method is disclosed for assembling a transmission flange and a driveshaft flange that defines a plurality of holes and countersink recesses. A bolt is assembled into each of the holes and countersink recesses and a bolt retainer is attached to each of the bolts and nested inside the countersink recesses to retain the bolts on the driveshaft flange. The bolts on the driveshaft flange are then installed into the threaded holes of the transmission flange.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 23, 2017
    Assignee: FORD MOTOR COMPANY
    Inventors: Christopher Peter Nicholas, Scott Wilson, Brian John Brown, Duane Allan Lewis