Abstract: Shrink film having a desirable balance of properties is manufactured from a polyethylene blend composition having a fractional melt index and a molecular weight distribution of from about 2.5 to about 7. The blend composition comprises a first blend component that is made with a single site catalyst and has a molecular weight of greater than about 140,000 and a first density, d1. The blend composition also contains a second blend component having a lower molecular weight and a second density, d2, that is greater than the density of d1 in an amount of from about 0.018 to about 0.032 g/cc. The films of this disclosure may be used, for example, as an overwrap or pallet wrap to protect goods during shipping and in food packaging applications (such as shrink wrap for frozen poultry).

Abstract: An assembly and process for forming a two stage extrusion of an elongated marine dock from a plasticized material, such as including but act limited to extruding a first generally “L” shaped bracket from a first more rigid thermoplastic, following which a cross head die arrangement is utilized in order to extrude a secondary arcuate and flexible material in extending fashion from a lower side of the “L” bracket. The secondary/flexible elastomer is extracted in an open flexed position relative to the first extruded bracket, and further such that, following completion, can be flexed into a closed engagement with an upper perpendicularly extending side of the bracket.

Abstract: An assembly and process for forming a two stage extruded pipe having a central inner sleeve and a pair of outer attached lobes. The central sleeve shaped (also termed a grout receiving tube) is produced in an initial extrusion operation, following which it enters a cross head operation where a pair of outer lobes are attached to cross sectional exterior surface locations according to a second stage extrusion operation so as to be integrally formed therewith. Other steps include cooling of the dual stage extruded pipe, as well as sectioning and stacking the pipe. Additional steps include forming elongated slots or apertures into the central sleeve portion of the finished extrusion, such in non-interfering fashion with the individual passageway defining and lobes.

Abstract: A method of aligning the radiation beam in a radiotherapy system comprising a source for producing a beam of radiation and an imaging device for imaging from the beam, both mounted to be rotatable about an axis, a fiducial phantom between the source and imaging device, the method comprising: rotating the beam and imaging device in a trajectory about the axis while obtaining images of the fiducial phantom from a plurality of different angles, at least one image including a feature of the imaging apparatus, adjusting the trajectory of the source relative to that feature to position the isocenter substantially in the center of the volume, determining from each image of the fiducial phantom the position of the source at the rotational position the image was obtained, and calculating the center of rotation of the positions of the source to define the isocenter of the system.

Abstract: A driveshaft includes a shaft defining a passageway and a constant velocity joint defining an interior and having a cover defining a hole. A grommet is disposed in the hole and defines a fluid passage into the interior. The CV joint is coupled to the shaft such that the shaft is disposed against the grommet with the passageway and the fluid passage in fluid communication to vent air from the interior into the passageway.

Abstract: A free-standing wall includes concrete base blocks adjacent to each other forming a base course; a first set of concrete wall blocks stacked on the base course and on each other to form a first wall face; and a second set of concrete wall blocks stacked on the base course and on each other to form a second wall face that faces the opposite direction from the first wall face and that has the same number of courses as the first plurality of wall blocks. Methods of constructing the wall arrangement include laying the base blocks next to each other end to end; stacking individual blocks of a first set of blocks on the base course and then on each other to form a first wall face; stacking individual blocks of the second set of blocks on the base course and then on each other to form a second wall face that faces a direction opposite of the first wall face.

Abstract: The present invention relates to the compound of formula (I) and to compositions comprising the same and to the use of the compound and to compositions of the compound in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compound.

Abstract: This disclosure relates to films comprising at least one layer of an ethylene interpolymer product. The ethylene interpolymer product comprises a first ethylene interpolymer, a second ethylene interpolymer and optionally a third ethylene interpolymer; wherein the ethylene interpolymer product has ?0.03 terminal vinyl unsaturations per 100 carbon atoms and ?3 parts per million (ppm) of a total catalytic metal; and optionally a Dilution Index, Yd, greater than 0. The disclosed ethylene interpolymer products have a melt index from about 0.4 to about 10 dg/minute, a density from about 0.900 to about 0.940 g/cm3, a polydispersity (Mw/Mn) from about 2 to about 12 and a CDBI50 from about 20% to about 98%. Further, the ethylene interpolymer products are a blend of at least two ethylene interpolymers; where one ethylene interpolymer is produced with a single-site catalyst formulation and at least one ethylene interpolymer is produced with a heterogeneous catalyst formulation.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: A portable lighting device adapted to provide an area light, said device including a body having a battery housing to hold batteries to power said device. The device includes a light panel functioning as a lens to act as an area light emitter, characterized in the said light panel is slidable into and out of said body, said light panel being constructed of a substantially flat panel portion.

Abstract: The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.

Abstract: This invention relates to a process for the preparation of surface-functionalised metal oxide, metal sulphide, metal selenide or metal telluride nanoparticles, a process for the preparation of a composite material comprising such nanoparticles, nanoparticles and a composite material produced thereby, the use of such nanoparticles in catalysis and a catalyst comprising such nanoparticles.

Abstract: A constant-velocity joint includes an outer race, inner race, end cap, and seal. The outer race defines a cavity, an opening to the cavity, and a through hole configured to receive a fastener. The inner race is disposed within the cavity and is rotatably connected to the outer race via a plurality of ball bearings. The end cap is secured to the outer race and covers the opening. The seal is disposed between the outer race and the end cap. The seal defines a channel that is in fluid communication with the cavity and the through hole. The channel is configured to vent air between the cavity and through hole.

Abstract: A driveshaft includes a shaft defining a passageway and a constant velocity joint defining an interior and having a cover defining a hole. A grommet is disposed in the hole and defines a fluid passage into the interior. The CV joint is coupled to the shaft such that the shaft is disposed against the grommet with the passageway and the fluid passage in fluid communication to vent air from the interior into the passageway.

Abstract: The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of these peptides. In one embodiment, the peptide comprises or consist of the amino acid sequence of TSFXaa1EYWXaa3LLXaa2, where Xaa1 is (R)-2-(7?-octenyl)alanine or derivative thereof, or is (R)-2-(4?-pentenyl)alanine or derivative thereof; and Xaa2 and Xaa3 are independently any type of amino acid or modified amino acid. In another embodiment, the peptide comprising or consisting of the amino acid sequence of TSFXaa1EYW Xaa3LLXaa2ENXaa5, wherein Xaa1 and Xaa3 are any type of amino acid or modified amino acid; Xaa2 is S, or P, or (S)-2-(4?-pentenyl)alanine or a derivative of (S)-2-(4?-pentenyl)alanine; and wherein Xaa5 is F or Y.

Abstract: A center-bearing assembly includes an annular housing having a circumferential wall with a lip extending radially inward and includes a flange outboard of the circumferential wall. A roller bearing is sized to encircle a vehicle driveshaft and is disposed within the housing between the lip and the flange. An annular retainer is connected to the flange and includes an annular notch configured to shear in response to impact to the driveshaft allowing the bearing to release from the housing.

Abstract: A center-bearing assembly includes an annular housing having a circumferential wall with a lip extending radially inward and includes a flange outboard of the circumferential wall. A roller bearing is sized to encircle a vehicle driveshaft and is disposed within the housing between the lip and the flange. An annular retainer is connected to the flange and includes an annular notch configured to shear in response to impact to the driveshaft allowing the bearing to release from the housing.

Abstract: The various embodiments of the present invention relate to a polymerization reactor where the agitator mixing performance is optimized for use with a high activity catalyst and methods for developing the same.

Abstract: A lighting device (10) having a base housing (12) to receive one or more batteries therein to power a light source located in a light housing (14). The light housing (14) being pivotally attached to the base housing (12) at pivot points on both sides of the base housing (12), wherein a handle (24) is provided which extends along the axis of rotation (13) between the pivot points.

Abstract: The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.