Abstract: This invention relates to the protein, Mycobacterium paratuberculosis acylase (mpa) and the gene encoding mpa, which we have identified in the pathogen Mycobacterium paratuberculosis Mptb (also designated Mycobacterium avium subspecies paratuberculosis MAP), and to their use in the diagnosis of Mptb/MAP infections in animals and humans, as well as their use as components of vaccines for the prevention and treatment of diseases caused by Mptb/MAP. The importance of an intact uninterrupted mpa gene as a determinant of pathogenicity in Mptb/MAP is recognized and the invention also provides attenuated strains of normally pathogenic Mptb/MAP and other mycobacteria in which mpa has been inactivated, for use as vaccines.

Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.

Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.

Abstract: A delivery system, including: a material for storing molecules and/or nanoparticles by substantially binding said molecules and/or nanoparticles to said material; means for applying an electric field to said material to release said molecules and/or nanoparticles; and means for applying an ultrasonic signal to said material to transport said molecules and/or nanoparticles through said material to a surface for delivery to an entity.

Abstract: The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP.

Abstract: An exercise device includes two foot carriage assemblies. The foot carriage assemblies are operable to support a user's feet on a frame and to travel along a generally lateral path of motion. The foot carriages are operable to engage first and second torque tubes, which in turn participate in resisting the lateral movement of the foot carriages. A lateral striding motion on the exercise device may include a simulation of a motion associated with skating and/or skiing.

Abstract: A method for enabling strong mutual authentication between two computers or devices in a communication system. A user attempting to gain access to a first computer transmits login information to the first computer. The first computer transmits a first message, including a first key encrypted by a second key, to the second computer. The first computer then transmits a second message to a third device. The second message includes the second key needed by the second computer to decrypt the first message. The third device uses the user's login information to obtain the user's private key, which the third device uses to obtain the second key. The third device transmits the second key in a third message to the second computer. The second computer then uses the second key to decrypt the first message and obtain the first key. Once the second computer obtains the first key, the second computer switches the role of the keys from the first message by encrypting the second key with the first key into a fourth message.

Abstract: An exercise device includes two foot carriage assemblies. The foot carriage assemblies are operable to support a user's feet on a frame and to travel along a generally lateral path of motion. The foot carriages are operable to engage first and second torque tubes, which in turn participate in resisting the lateral movement of the foot carriages. A lateral striding motion on the exercise device may include a simulation of a motion associated with skating and/or skiing.

Abstract: Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and optionally substituted C1-6 alkyl, or R5 and R8 are an alkylene chain, are novel.

Abstract: Compounds according to formula (I) wherein n is 0-3, R′ is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and optionally substituted C1-6 alkyl, or R5 and R8 are an alkylene chain, are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.

Abstract: An assay method for determining binding of a test compound to pyruvate dehydrogenase kinase (PDHK) at a given site comprising determining (a) the degree of polarisation of the light emitted by a PDHK complex formed by contacting in solution a known concentration of PDHK with a known concentration of a fluorescent compound known to bind to PDHK at that site, and (b) the degree of polarisation of the light emitted by a PDHK complex formed by contacting in solution the test compound, the same concentration of PDHK and the same concentration of the fluorescent compound, a lesser value of the degree of polarisation (b) than that of (a) being taken as indicative of binding of the test compound to that site.

Abstract: Described are a system and method for securely distributing session keys over a network to each node in a chain of computer system nodes. The chain of nodes recursively constructs and presents a nested request to the authentication server. The nested request includes a request from each of the nodes in the chain requiring a session key to communicate with a neighboring node. The authentication server recursively unravels the request and recursively prepares a response that includes a session key for each node that submitted a request. The response traverses the chain of nodes in the reverse order taken by the nested request to reach the authentication server. Each node receiving the response extracts the portion of the response directed to that node, and forwards the remainder of the response, if any, to the next node in the chain. Thus, with a single traversal of the chain of nodes each node receives at least one session key.

Abstract: Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-8 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and optionally substituted C1-6 alkyl, or R5 and R8 are an alkylene chain, are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.

Abstract: Compounds according to formula (I) wherein n is 0-3, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen and optionally substituted C1-6 alkyl, or R5 and R8 are an alkylene chain, are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.

Abstract: Compounds of the formula: wherein R1, Y, W, A and R2 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage.

Abstract: A method and apparatus for monitoring posture deficiencies in the spine and including a flexible body (30) encapsulating a flexible operating arm (31) cantilevered from a base moulding (34). The operating arm (31) is provided with upper (37) and lower (40) strain gauges bonded to the upper and lower faces respectively of the operating arm (31) at the point beyond the stiffening base moulding (34) to ensure that differential strain is experienced on deflection of the operating arm (31). Wire tails (41) are terminated as a PCB assembly (45) mounted to the printed circuit support (35), which assembly comprises a PC board bearing an LSI processor (46), rechargeable battery (47), vibrating motor (50) and inductive coil (51) selected to fulfil the functions of transmitting and receiving element, and inductive power supply for charging the battery (47), under the control of processor (46).

Abstract: The invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon or nitrogen atom said group being optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by 1 or 2 substituents each independently selected from C1-C4 alkyl, C2-C4 alkenyl, C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, C3-C7 cycloalkyloxy, —COOH, C1-C4 alkoxycarbonyl, —CONR3R4, —NR3R4, —S(O)p(C1-C4 alkyl), —SO2NR3R4, aryl, aryloxy, aryl(C1-C4)alkoxy, and het, said C1-C4alkyl being optionally substituted by C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, halo(C1C4)alkoxy, C3-C7 cycloalkyloxy, C3-C7 cycloalkyl (C1-C4) alkoxy, —COOH, C1-C4 alkoxycarbonyl, —CONR3R4, —NR3R4,—S(O)p(C1-C4 alkyl), —SO2(aryl), —SO2NR3R4 morpholino, aryl, aryloxy, aryl(C1-C4)

Abstract: An emergency flight control system is disclosed for lateral control using only differential engine thrust modulation of multiengine aircraft having at least two engines laterally displaced to the left and right from the axis of the aircraft in response to a heading angle command .psi..sub.c to be tracked. By continually sensing the heading angle .psi. of the aircraft and computing a heading error signal .psi..sub.e as a function of the difference between the heading angle command .psi..sub.c and the sensed heading angle .psi., a track control signal is developed with compensation as a function of sensed bank angle .PHI., bank angle rate .phi., or roll rate p, yaw rate .tau., and true velocity to produce an aircraft thrust control signal ATC.sub..psi.(L,R).

Abstract: An improved polymer film material for the packaging of perishable foodstuffs, wherein the surface structure of the polymer is altered by means of an ion bombardment process so as to reduce the rates of transport of oxygen and water vapor through the polymer material wherein the polymer film material is produced by subjecting at least one surface of the film to ion bombardment with ions selected from the group consisting of hydrogen, carbon, nitrogen, helium, and argon at energies of 30-80 KeV and ion doses in the range of 10.sup.12 to 10.sup.18 ions/cm.sup.2.

Abstract: Compounds of formula (I): ##STR1## and their pharmaceutically acceptable salts, wherein R.sup.1 and R.sub.2 are each independently Cl, Br, CH.sub.3, CH.sub.2 CH.sub.3 or CF.sub.3 ; R.sup.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 ; and X is a 5-membered heterocyclic group containing up to four nitrogen atoms, attached via a nitrogen atom, the said group being optionally substituted by C.sub.1 -C.sub.6 alkyl or (CH.sub.2).sub.n NR.sup.4 R.sup.5, wherein n is an integer from 1 to 5 and R.sup.4 and R.sup.5 are each independently H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.1 -C.sub.4 alkyl substituted by phenyl or pyridyl, or R.sup.4 and R.sup.5 are linked to form, together with the nitrogen atom to which attached, a pyrrolidine, piperidine, piperazine, N-(C.sub.1 -C.sub.4 alkyl) piperazine, morpholine or azepine group, or, when X is triazolyl, said group may optionally be benzofused, are NMDA antagonists of value in the treatment of acute neurodegenerative disorders, e.g.