Abstract: Compounds of the formula: wherein R1, Y, W, A and R2 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage.

Abstract: A method and apparatus for monitoring posture deficiencies in the spine and including a flexible body (30) encapsulating a flexible operating arm (31) cantilevered from a base moulding (34). The operating arm (31) is provided with upper (37) and lower (40) strain gauges bonded to the upper and lower faces respectively of the operating arm (31) at the point beyond the stiffening base moulding (34) to ensure that differential strain is experienced on deflection of the operating arm (31). Wire tails (41) are terminated as a PCB assembly (45) mounted to the printed circuit support (35), which assembly comprises a PC board bearing an LSI processor (46), rechargeable battery (47), vibrating motor (50) and inductive coil (51) selected to fulfil the functions of transmitting and receiving element, and inductive power supply for charging the battery (47), under the control of processor (46).

Abstract: The invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon or nitrogen atom said group being optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by 1 or 2 substituents each independently selected from C1-C4 alkyl, C2-C4 alkenyl, C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, C3-C7 cycloalkyloxy, —COOH, C1-C4 alkoxycarbonyl, —CONR3R4, —NR3R4, —S(O)p(C1-C4 alkyl), —SO2NR3R4, aryl, aryloxy, aryl(C1-C4)alkoxy, and het, said C1-C4alkyl being optionally substituted by C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, halo(C1C4)alkoxy, C3-C7 cycloalkyloxy, C3-C7 cycloalkyl (C1-C4) alkoxy, —COOH, C1-C4 alkoxycarbonyl, —CONR3R4, —NR3R4,—S(O)p(C1-C4 alkyl), —SO2(aryl), —SO2NR3R4 morpholino, aryl, aryloxy, aryl(C1-C4)

Abstract: An emergency flight control system is disclosed for lateral control using only differential engine thrust modulation of multiengine aircraft having at least two engines laterally displaced to the left and right from the axis of the aircraft in response to a heading angle command .psi..sub.c to be tracked. By continually sensing the heading angle .psi. of the aircraft and computing a heading error signal .psi..sub.e as a function of the difference between the heading angle command .psi..sub.c and the sensed heading angle .psi., a track control signal is developed with compensation as a function of sensed bank angle .PHI., bank angle rate .phi., or roll rate p, yaw rate .tau., and true velocity to produce an aircraft thrust control signal ATC.sub..psi.(L,R).

Abstract: An improved polymer film material for the packaging of perishable foodstuffs, wherein the surface structure of the polymer is altered by means of an ion bombardment process so as to reduce the rates of transport of oxygen and water vapor through the polymer material wherein the polymer film material is produced by subjecting at least one surface of the film to ion bombardment with ions selected from the group consisting of hydrogen, carbon, nitrogen, helium, and argon at energies of 30-80 KeV and ion doses in the range of 10.sup.12 to 10.sup.18 ions/cm.sup.2.

Abstract: Compounds of formula (I): ##STR1## and their pharmaceutically acceptable salts, wherein R.sup.1 and R.sub.2 are each independently Cl, Br, CH.sub.3, CH.sub.2 CH.sub.3 or CF.sub.3 ; R.sup.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 ; and X is a 5-membered heterocyclic group containing up to four nitrogen atoms, attached via a nitrogen atom, the said group being optionally substituted by C.sub.1 -C.sub.6 alkyl or (CH.sub.2).sub.n NR.sup.4 R.sup.5, wherein n is an integer from 1 to 5 and R.sup.4 and R.sup.5 are each independently H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.1 -C.sub.4 alkyl substituted by phenyl or pyridyl, or R.sup.4 and R.sup.5 are linked to form, together with the nitrogen atom to which attached, a pyrrolidine, piperidine, piperazine, N-(C.sub.1 -C.sub.4 alkyl) piperazine, morpholine or azepine group, or, when X is triazolyl, said group may optionally be benzofused, are NMDA antagonists of value in the treatment of acute neurodegenerative disorders, e.g.

Abstract: A process for preparing a compound of general formula ##STR1## where Ar represents an optionally substituted aromatic or heteroaromatic group, the process comprising reacting a compound of general formulaAr--C(L.sup.1).sub.2 Cl (II)where each L.sup.1 independently represents a leaving group (preferably a chlorine atom), with water in the presence of a Lewis acid and a chlorocarbon solvent which includes at least two chlorine atoms, is disclosed.

Abstract: A buckle assembly configured for one-handed release by an operator thereof, including a pair of clasps, each having a release tab. Each of the clasps are adapted for release by pressure from a single finger of the operator on the release tab. A main buckle is designed to independently and releasably engage the clasps. The main buckle is configured so that both clasps are releasable from the main buckle with two fingers of one hand.

Abstract: An aerobic conditioning apparatus for use by a trainee in simultaneously exercising the upper and lower body in a smooth shock-free manner substantially simulating movement of the arms and legs during swimming. The apparatus includes a supporting frame, first and second foot supporting assemblies mounted on the supporting frame for controlling the movement of the right and left feet of the user respectively to an oscillatory motion along first and second paths between first forward positions and a second rearward position, first and second hand engaging assemblies mounted on the supporting frame for controlling the movement of the right and left hands of the user respectively to an oscillatory motion along paths between a first upraised position and a second lowered position, and synchronizing mechanisms mounted on the supporting frame for causing synchronous movement of the foot engaging assemblies and the hand engaging assemblies.

Abstract: A fanny pack in combination with an insulated handwarmer muff provides a device for carrying objects and a handwarming device, each of which can be used independently of the other. The handwarmer pack is worn to the rear of the user's body on the hips. When turned to the front of the user's body the user's hands may be inserted into an insulated handwarmer muff through separate openings which do not give access to the compartment in which objects are carried. With the muff removed, the other contents of the pack are unaffected, while the muff can still be used to warm the hands, or opened flat as a seat cushion. The pocket which housed the muff is then available for additional carrying space, while the contents of the main compartment, or fanny pack are accessible by means of a separate opening at the top.

Abstract: A line switch including a concentrator arrangement for coupling telephone calls between a plurality of subscriber lines and a plurality of port group highways to a central office switching network in a telephony system. The analog voice signals are first digitized and multiplexed into time slot channels on line group highways for transfer to the concentrator arrangement. The concentrator arrangement couples the digitized voice information signals between time slot channels on any of the line group highways and any of the port group highways. The line switch includes control circuitry that selects the time slot channel, line group highway and port group highway to couple the digitized voice information signals between the subscriber line and the central office matrix switch through the concentrator.