Patents by Inventor John C. Sih

John C. Sih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of camptothecin derivatives
    Patent number: 6444820
    Abstract: This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as a novel method of making mappicine.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: September 3, 2002
    Inventors: Kevin E. Henegar, John C. Sih
  • Intermediates useful in making mappicine and related compounds
    Patent number: 6235907
    Abstract: This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as a novel method of making mappicine.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: May 22, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kevin E. Henegar, John C. Sih
  • Heterocyclic compounds for the treatment of CNS and cardiovascular disorders
    Patent number: 6133446
    Abstract: Novel aromatic bicyclic amines of formula (I) ##STR1## are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: October 17, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ruth E. TenBrink, Michael D. Ennis, Chiu-Hong Lin, Robert A. Lahti, Arthur G. Romero, John C. Sih
  • Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
    Patent number: 6121451
    Abstract: This invention relates to intermediates and processes for the synthesis of camtothecin derivatives, such as irinotecan. Related procedures and compounds are disclosed, such as a method of making mappicine.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: September 19, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Kevin E. Henegar, John C. Sih
  • Process for the preparation of roquinimex
    Patent number: 5912349
    Abstract: The present invention is an improved process to prepare roquinimex (IV) which comprises:(1) contacting N-methyl-N-phenyl-.alpha.-carbomethoxyamide (V) with from about one to about two equivalents of base and(2) contacting the mixture of step (1) with N-methylisatoic anhydride (I).
    Type: Grant
    Filed: January 13, 1998
    Date of Patent: June 15, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventor: John C. Sih
  • .alpha.-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
    Patent number: 5245046
    Abstract: Provided are novel .alpha.-aminoindole-3-acetic acid derivatives having the formula ##STR1## wherein R through R9 are as defined in the specification, and pharmacologically acceptable salts of compounds wherein R.sub.9 is not OM, which are useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: September 14, 1993
    Assignee: The Upjohn Company
    Inventors: Gilbert A. Youngdale, John C. Sih, Steven P. Tanis, Chiu-Hong Lin
  • Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles
    Patent number: 5077407
    Abstract: The present invention provides novel substituted 2-[monoannelated(3,4- 4,5-, and 5,6-)pyridylalkylenesulfinyl]-benzimidazoles with gastric acid inhibiting effects.
    Type: Grant
    Filed: October 31, 1988
    Date of Patent: December 31, 1991
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • N-substituted derivatives of 2-(pyridylalkenesulfinyl) benzimidazoles as gastric antisecretory agents
    Patent number: 4873337
    Abstract: The present invention provides novel N-substituted derivatives 2-(pyridylalkylenesulfinyl)benzimidazoles with gastric acid inhibiting effects.
    Type: Grant
    Filed: August 3, 1987
    Date of Patent: October 10, 1989
    Assignee: The Upjohn Company
    Inventors: John C. Sih, Moo J. Cho
  • Pyridyl-substituted benzothiophenes
    Patent number: 4855435
    Abstract: The present invention provides novel pyridinyl- benzothiophenes and derivatives thereof which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: August 8, 1989
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
    Patent number: 4619997
    Abstract: The present invention provides substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles with gastric acid inhibiting effects.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: October 28, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Pyridyl-substituted benzothiophenes
    Patent number: 4611059
    Abstract: The present invention provides novel pyridinyl-benzothiophenes and derivatives thereof which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: September 9, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Novel 9-substituted carbacyclin analogs
    Patent number: 4590297
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: May 20, 1986
    Assignee: The Upjohn Company
    Inventors: Paul A. Aristoff, John C. Sih
  • 9-Substituted carbacyclin analogs
    Patent number: 4585886
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 29, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
    Patent number: 4575554
    Abstract: The present invention provides novel substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles with gastric acid inhibiting effects.
    Type: Grant
    Filed: September 6, 1984
    Date of Patent: March 11, 1986
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 9-Substituted carbacyclin analogs
    Patent number: 4533749
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: February 16, 1982
    Date of Patent: August 6, 1985
    Assignee: The Upjohn Company
    Inventors: Paul A. Aristoff, John C. Sih
  • 9-Substituted carbacyclin analogs
    Patent number: 4490555
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: December 25, 1984
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-7a-homo-PGI.sub.1 and 19-hydroxy-19-methyl-7a-homo-PGI.sub.1 compounds
    Patent number: 4474966
    Abstract: The present invention provides novel 19-hydroxy-7a-homo-PGI.sub.1 19-hydroxy-19-methyl-7a-homo-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: December 31, 1981
    Date of Patent: October 2, 1984
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • Imidazolyl-substituted benzothiophenes
    Patent number: 4447620
    Abstract: The present invention provides novel imidazolyl-benzothiophenes and derivatives thereof which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: May 8, 1984
    Assignee: The Upjohn Company
    Inventors: John C. Sih, Chiu-Hong Lin
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-PG compounds
    Patent number: 4398025
    Abstract: The present invention provides novel 2-decarboxy-2-hydroxymethyl-19,20-didehydro-13,14-dihydro-PG.sub.1 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: January 7, 1982
    Date of Patent: August 9, 1983
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-6-iodo-PGF.sub.1 compounds
    Patent number: 4337337
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-6-iodo-PGF.sub.1 compounds. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: June 29, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih