Patents by Inventor John C. Sih

John C. Sih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy PGF.sub.1 amides
    Patent number: 4337203
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-PGF.sub.1 amides. These compounds are useful for a wide variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: June 29, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-6-iodo-PGF.sub.1 amides
    Patent number: 4337338
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-6-iodo-PGF.sub.1 amides. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: June 29, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 2-Decarboxy-2-tetrazolyl-PG.sub.1 compounds
    Patent number: 4336392
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4336393
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.2 compounds
    Patent number: 4336371
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-13,14-dihydro-PG.sub.2 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-PG.sub.2 compounds
    Patent number: 4336372
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-PG.sub.2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 22, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-7.alpha.-homo-PGI.sub.1 compounds
    Patent number: 4328156
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-7.alpha.-homo-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: May 4, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2,5-Inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-PGF.sub.1 amides
    Patent number: 4328338
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-PGF.sub.1 amides. These compounds are useful for a wide variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: May 4, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 2,5-Inter-o-phenylene-3,4 -dinor-6,9.alpha.-epoxy-6.beta.-5-iodo-PGF.sub.1 amides
    Patent number: 4324889
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-5-iodo-PGF.sub.1 amides. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: April 13, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 2,5-Inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-PGF.sub.1 compounds
    Patent number: 4321370
    Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-PGF.sub.1 compounds. These compounds are useful for a wide variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: March 23, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 19-Hydroxy-7a-homo-PGI.sub.1 compounds
    Patent number: 4321203
    Abstract: The present invention provides novel 19-hydroxy-7a-homo-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: March 23, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-19-methyl-6a-carba-PGI.sub.1 compounds
    Patent number: 4312983
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-19-hydroxy-19-methyl-6a-carba-PGI.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-9-deoxy-PGF.sub.1 compounds
    Patent number: 4312810
    Abstract: This invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) and 5,6-dehydroprostacyclin (PGI.sub.1) and 5,9.alpha.-epoxy-9-deoxy-PGF.sub.1, wherein between the position beta to the carboxy (C-2) and C-5 there is substituted an inter-o-phenylene for the ethylene chain. These novel 2,5-inter-o-phenylene-3,4-dinor-prostaglandin or prostacyclin-type compounds are useful for certain of the same pharmacological purposes as prostacyclin, particularly being smooth muscle stimulators, blood pressure depressors and platelet aggregation inhibitors. Also provided are novel intermediates therefor, namely corresponding interphenylene-containing PGF.sub.2.alpha. and 5-halo-PGI.sub.1 and 6-halo-5,9.alpha.-epoxy-9-deoxy-PGF.sub.1 compounds.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventors: Udo F. Axen, John C. Sih
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-6-oxo-PGF .sub.1 compounds
    Patent number: 4312984
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-19-hydroxy-6-oxo-PGF.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-6-oxo-PGF.sub.1 amides
    Patent number: 4312997
    Abstract: The present invention provides novel 19-hydroxy-6-oxo-PGF.sub.1 amides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-19-methyl-6-oxo-PGF.sub.1 compounds
    Patent number: 4311834
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-19-hydroxy-19-methyl-6-oxo-PGF.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: January 19, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-19-hydroxy-6a-carba-PGI.sub.1 compounds
    Patent number: 4311835
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-19-hydroxy-6a-carba-PGI.sub.1 sulfonylamides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: January 19, 1982
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 13,14-Didehydro-11-deoxy-9-deoxy-9-methylene-19-oxo-PGF.sub.2 compounds
    Patent number: 4302596
    Abstract: The present invention provides novel 13,14-didehydro-11-deoxy-9-deoxy-9-methylene-19-oxo-PGF.sub.2 compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: November 24, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-PGI.sub.1 compounds
    Patent number: 4301079
    Abstract: The present invention provides novel 19-Hydroxy-19-methyl-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: November 17, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-6a-carba-PGI.sub.2 compounds
    Patent number: 4297504
    Abstract: The present invention provides novel 19-hydroxy-6a-carba-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.CROSS REFERENCE TO RELATED APPLICATIONThe present invention is a divisional application of U.S. Ser. No. 054,811, filed July 5, 1979, now U.S. Pat. No. 4,225,508.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: October 27, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih