Patents by Inventor John C. Sih

John C. Sih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11-Deoxy-11-hydroxymethyl-inter-phenylene-19-oxo-PGE.sub.1 compounds
    Patent number: 4277611
    Abstract: The present invention provides novel 11-deoxy-11-hydroxymethyl-inter-phenylene-19-oxo-PGE.sub.1 compounds, which are useful for a variety of pharmacological purposes, e.g. antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: July 7, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-6-oxo-PGF.sub.1 intermediates
    Patent number: 4277613
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-6-oxo-PGF.sub.1 intermediates for preparing prostacyclin analogs which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: July 7, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-inter-phenylene-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4277619
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-inter-phenylene-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: July 7, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 11-Deoxy-19-oxo-PGF.sub.2 compounds
    Patent number: 4277615
    Abstract: The present invention provides novel 11-Deoxy-19-oxo-PGF.sub.2 compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: July 7, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 11-Deoxy-19-oxo-PGE.sub.2 compounds
    Patent number: 4277616
    Abstract: The present invention provides novel 11-Deoxy-19-oxo-PGE.sub.2 compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: July 7, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19,20-Didehydro-PG.sub.1 compounds
    Patent number: 4276427
    Abstract: The present invention provides novel 19,20-didehydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19,20-Didehydro-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4276428
    Abstract: The present invention provides novel 19,20-didehydro-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19,20-Didehydro-13,14-dihydro-PG.sub.1, sulfonyl amides
    Patent number: 4276434
    Abstract: The present invention provides novel 19,20-didehydro-13,14-dihydro-PG.sub.1, sulfonyl amides, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Keto-PG sulfonylamides
    Patent number: 4276436
    Abstract: The present invention provides novel 19-keto-PG sulfonylamides, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19,20-Didehydro-PG.sub.1, sulfonyl amides
    Patent number: 4276435
    Abstract: The present invention provides novel 19,20-didehydro-PG.sub.1, sulfonyl amides methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-inter-oxa-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4275232
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-inter-oxa-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.CROSS REFERENCE TO RELATED APPLICATIONSThe present application is a division of Ser. No. 025,878, filed Apr. 2, 1979, now abandoned.PRIOR ARTProstaglandin analogs exhibiting hydroxylation in the 19-position are known in the art. See, for example, U.S. Pat. No. 4,127,612, Sih, J.C., Prostaglandins 13:831 (1977) and U.S. Pat. Nos. 3,657,316, 3,878,046, and 3,922,297. See also the additional references cited in U.S. Ser. No. 025,878.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: June 23, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-13,14-dihydro-PG.sub.1 compounds
    Patent number: 4275231
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG.sub.1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: June 23, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-7a-homo-PGI.sub.2 compounds
    Patent number: 4275008
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-7a-homo-PGI.sub.2 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: June 23, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-13,14-dihydro-PG.sub.2 compounds
    Patent number: 4275233
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG.sub.2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: June 23, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2 -Decarboxy-2-hydroxymethyl-9-deoxy-6.epsilon.,9.alpha.epoxy-16,16-difluor o-19-hydroxy-PGF.sub.1
    Patent number: 4273718
    Abstract: The present invention provides novel 19-Hydroxy-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: June 16, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-6,9.alpha.-epoxymethano-PGF compounds
    Patent number: 4271078
    Abstract: The present invention provides novel 19-hydroxy-6,9.alpha.-epoxymethano-PGF compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: June 2, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 2-Decarboxy-2-tetrazolyl-19-keto-PG compounds
    Patent number: 4271292
    Abstract: The present invention provides novel 2-decarboxy-2-tetrazolyl-19-keto-PG compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: June 2, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-cis-4,5-didehydro-13,14-dihydro-PG.sub.1 analogs
    Patent number: 4271313
    Abstract: The present invention provides novel 19-hydroxy-cis-4,5-didehydro-13,14-dihydro-PG.sub.1 Analogs methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
    Type: Grant
    Filed: October 26, 1979
    Date of Patent: June 2, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 19-Hydroxy-19-methyl-6-hydroxy-7a-homo-PGI.sub.1 compounds
    Patent number: 4271077
    Abstract: The present invention provides novel 19-hydroxy-19-methyl-6-hydroxy-7a-homo-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: June 2, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih
  • 13,14-Dihydro-inter-phenylene-11-deoxy-19-oxo-PGE.sub.1 compounds
    Patent number: 4269994
    Abstract: The present invention provides novel 13,14-dihydro-inter-3,7-inter-m-phenylene-4,5,6-trinor-3-oxa-11-deoxy-19-o xo-PGE.sub.1 compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: May 26, 1981
    Assignee: The Upjohn Company
    Inventor: John C. Sih