Abstract: Consistent with the present disclosure, retention assemblies for maintaining the relative position of adjacent vertebral bodies and an implantable device positioned therebetween are described herein. Such retention assemblies may include a plate body and a coupler. The plate body may include structures to allow fixedly attaching the retention assembly to adjacent intervertebral bodies, using vertebral body screws or the like, for example. Furthermore, the coupler may include expandable structures to engage a portion of an implantable device to fixedly attach the retention assembly to the implantable device. Accordingly, once the retention assembly is deployed, the implantable device is fixedly held in relation to the adjacent vertebral bodies, decreasing post operative movement of the implantable device relative to the adjacent vertebral bodies.

Abstract: A cryogenic refrigerator uses a mixture of helium-3 and helium-4. Gaseous helium is pumped from a reservoir containing a liquid mixture of helium-3 and helium-4 to cause cooling and a phase separation into an upper helium-3 rich phase which floats at the top for further evaporation and a lower dilute phase below the helium-3 rich phase. This separation enables operation at temperatures typical of a helium-3 refrigerator while initial liquefaction of the mixture is easier than liquefaction of pure helium-3 and can use a smaller amount of helium-3. Embodiments of the refrigerator can provide continuous cooling.

Abstract: This specification relates to systems (100), methods and apparatus for intelligently controlling the drum rotation of a concrete mixer (104). According to a first aspect of this specification, there is described a method for controlling a concrete mixing drum (104) on a concrete mixer vehicle (102), the method comprising, for each of a plurality of time-steps: inputting, into one or more machine-learned models (210), input data comprising a current state of the concrete mixer vehicle and one or more delivery requirements for a concrete mix in the concrete mixing drum; processing, using the one or more machine-learned models, the input data to generate a drum rotation cycle data (c) for the concrete mixing drum; outputting, from the one or more machine-learned models, the drum rotation cycle data; and controlling the concrete mixing drum based on the generated drum rotation cycle data.

Abstract: The present disclosure relates to methods for treating or preventing or delaying progression or reducing or inhibiting or hindering development of a complication associated with sickle cell disease in a subject suffering from sickle cell disease, the method comprising administering to the subject a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling and/or G-CSF activity.

Abstract: A reaction socket assembly includes a socket configured to slidingly engage an associated nut so as to define a socket axis. The socket engages the associated nut for paired rotational movement. The reaction socket assembly also includes a lower part disposed coaxially exterior to the socket. The lower part defines a plurality of recesses and a plurality of keyways and the plurality of recesses are fluidly connected with the respective plurality of keyways. The reaction socket assembly also includes a plurality of keys selectively disposed in the plurality of recesses and the plurality of keyways and a sleeve disposed coaxially exterior to the lower part. The sleeve includes a plurality of ramps that are selectively received in the plurality of recesses.

Abstract: The instant invention relates to a composition useful as a precursor for imparting flame-retardant properties to textile articles, comprising a condensate of: (a) a tetrakis (hydroxyorgano) phosphonium sulfate THPS; (b) urea, or alternatively thiourea; (c) optionally, and preferably, an aliphatic hydroxyl-reactive compound, such an amine wherein said composition has a very low free formaldehyde content, namely of less than 0.1%.

Abstract: Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy without hypertension are disclosed. Preferred methods comprise the administration of a therapeutically effective amount of the dual SGLT1/2 inhibitor sotagliflozin.

Abstract: Methods of using a sodium glucose cotransporter 2 (SGLT2) inhibitor to treat type 1 diabetes, improve cardiovascular health, slow kidney function decline, reduce the risk of cardiovascular death, and reduce the risk of hospitalization for heart failure while minimized adverse events such as diabetic ketoacidosis and severe hypoglycemia are disclosed. In preferred methods, the SGLT2 inhibitor is sotagliflozin. Methods of prescribing and administering sotagliflozin are also disclosed.

Abstract: A limb support fastening arrangement for fastening a limb support to a limb of a wearer is disclosed. The arrangement comprises a first and second fastening portion, the first portion comprising an inflatable chamber comprising an upper and lower chamber wall and a first fastener disposed proximate the upper chamber wall, the lower chamber wall being arranged in use, to extend proximate the limb of the wearer. The second portion similarly comprises an inflatable chamber comprising an upper and lower chamber wall and a second fastener disposed proximate the upper chamber wall, the lower chamber wall being arranged in use, to extend proximate the limb of the wearer. The fastener associated with the first portion is arranged to detachably couple with the fastener associated with the second portion to detachably couple the first and second portions together, by positioning the lower chamber wall of one portion over the upper chamber wall of the other portion.

Abstract: The present disclosure relates to a controller (20) for controlling operation of an access control device (2) for a vehicle (3). The access control device (2) is selectively operable in a first operating mode (P1) and a second operating mode (P2). The access control device (2) is in a limited response mode when operating in the first operating mode (P1). The controller (20) includes a processor (24) and a memory means (23). The processor (24) is configured to determine a position of the access control device (2) and to generate a control signal for activating the first operating mode (P1). The control signal is generated in dependence on the determined position of the access control device (2). The controller (20) may be provided in the access control device (2). The present disclosure also relates to a method of controlling operation of an access control device (2).

Abstract: A reaction washer can include a castellated portion circumferentially disposed around a perimeter of the reaction washer and a main body portion defining an inner diameter that slidingly receives an associated threaded element therethrough. The castellated portion can include a plurality of castellations that cooperate to define an outer diameter of the reaction washer. Further, the main body can include a first side and a second side that face in opposite directions and an inner engagement ring that extends from the first side and is coaxially disposed between the inner diameter and the castellated portion. The inner engagement ring can include a plurality of serrations that each define a respective serration axis that do not intersect with the engagement axis.

Abstract: A method of applying an address space to data storage in a non-volatile solid-state storage is provided. The method includes receiving a plurality of portions of user data for storage in the non-volatile solid-state storage and assigning to each successive one of the plurality of portions of user data one of a plurality of sequential, nonrepeating addresses of an address space. The address range of the address space exceeds a maximum number of addresses expected to be applied during a lifespan of the non-volatile solid-state storage. The method includes writing each of the plurality of portions of user data to the non-volatile solid-state storage such that each of the plurality of portions of user data is identified and locatable for reading via the one of the plurality of sequential, nonrepeating addresses of the address space.

Abstract: A midsole for a shoe, where the midsole is 3D printed from an elastic polymeric material, the midsole comprising: a sole facing surface, a foot facing surface, a plurality of walls that in a first position are substantially perpendicular to the sole facing surface that extend from the sole facing surface to the foot facing surface where each wall has a height, where the plurality walls define a plurality of cells having a central axis that is substantially parallel to the walls and having a radius from a wall to the central axis, where the walls in a second position are configured to elastically deform upon application of an external force so that the deformation provides a change in the radius and/or the height, and where the walls are adapted to return to their first position upon removal of the external force.

Abstract: Techniques for map refinement (e.g., tracking data refinement) by an inside-out location tracking system may include computing a transform from a reference point to an epipolar line using an Essential Matrix derived from a reference frame camera motion in a live frame, computing several appearance errors between a feature associated with the reference point and other projected and optimized features, using a perpendicular projection hypothesis and an optimized point generated on the epipolar line, and evaluating the appearance errors using a greedy, ordered optimization. If the appearance error is less than a predetermined quality threshold, the optimized point is retained in tracking data. Otherwise the tracking data may be reset at the reference point location for reinitialization. An updated map and associated map data reflecting updated optimized points may be provided, for example, to a client device, as well as returned to a visual inertial odometry system.

Abstract: Techniques for optical flow translation estimation by an inside-out location tracking system may include generating an updated distance parameter by optimizing a distance parameter using a translation vector and a set of other fixed terms of a homography for a set of matched image point pairs in an image, determining whether to keep or to discard the updated distance parameter, optimizing the translation vector using a current distance parameter, either the updated distance parameter or a prior distance parameter that was retained, thereby generating an updated translation vector. An optical flow translation method also may include evaluating for convergence, and iteratively optimizing the distance parameter and the translation vector until there is convergence. Once there is convergence, a current updated translation may be output. Convergence may depend on one or more predetermined thresholds relating to a size of parameter updates, an error reduction, and/or a number of iterations.

Abstract: Techniques for hierarchical map relaxation by an inside-out location tracking system may include generating a pair of image patches comprising P×P patches of corresponding coordinates of a source image and a target image, evaluating the pair of image patches using hierarchical image pyramids, wherein an image in its original resolution is provided at a base level and is downsampled at each level above the base level. Hierarchical map relaxation may include iteratively estimating an error vector between the pair of image patches, finding a local map update vector for minimizing the error vector, expanding the local map update vector into a level below, evaluating the local map update by performing a greedy evaluation at each successive level until the base level, wherein the local map update from above is evaluated, and a final greedy evaluation is performed using another estimated error vector.

Abstract: The present disclosure relates to methods for treating or preventing or delaying progression or reducing or inhibiting or hindering development of a complication associated with sickle cell disease in a subject suffering from sickle cell disease, the method comprising administering to the subject a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling and/or G-CSF activity.

Abstract: Aspects of the disclosure relate to methods of promoting expression or activity of a dystrophin protein and/or methods of treating DMD in a subject. In some embodiments, the methods comprise administering to the subject a composition comprising complexes (e.g., muscle targeting complexes) comprising a phosphorodiamidate morpholino oligomer (e.g., useful for targeting DMD) covalently linked to an antibody (e.g., anti-TfR1 antibody).