Abstract: Methods for treating moderate-to-severe or severe atopic dermatitis in a pediatric subject are provided. In one aspect, the methods comprise administering to the subject one or more doses of an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

Abstract: A storage cluster includes a plurality of storage nodes. Each of the plurality of storage nodes includes nonvolatile solid-state memory and each of the plurality of storage nodes is configured to cooperate with others of the plurality of storage nodes having differing storage capacities in applying erasure coding. The plurality of storage nodes are configured to distribute the user data and metadata throughout the plurality of storage nodes.

Abstract: Intervertebral devices and systems, and methods of their use, are disclosed having configurations suitable for placement between two adjacent vertebrae, replacing the functionality of the disc therebetween. Intervertebral devices and systems contemplated herein are implantable devices intended for replacement of a vertebral disc, which may have deteriorated due to disease for example. The intervertebral devices and systems are configured to allow for ample placement of therapeutic agents therein, including bone growth enhancement material, which may lead to better fusion between adjacent vertebral bones. The intervertebral devices and systems are configured for use in minimally invasive procedures, if desired.

Abstract: Enhancing edges of objects in a thermal image comprises receiving a thermal image and generating a gradient magnitude image comprising a plurality of pixels having associated gradient magnitude values. The gradient magnitude image is partitioned into subregions and gradient magnitude statistics are calculated for each. Mapping parameters are calculated for each of the subregions that equalize and smooth a dynamic range of the corresponding gradient magnitude statistics across the subregions. The mapping parameters calculated for each of the subregions are applied to pixels in the subregions to generate enhanced gradient magnitude values having equalized luminosity and contrast, and a wireframe image is formed therefrom having enhanced edges of objects. The wireframe image is displayed on a display device, wherein the wireframe image appears as a decluttered line drawing where the enhanced edges have increased luminosity and contrast compared to the thermal image to reduce the cognitive load of the user.

Abstract: A method of applying an address space to data storage in a non-volatile solid-state storage is provided. The method includes receiving a plurality of portions of user data for storage in the non-volatile solid-state storage and assigning to each successive one of the plurality of portions of user data one of a plurality of sequential, nonrepeating addresses of an address space. The address range of the address space exceeds a maximum number of addresses expected to be applied during a lifespan of the non-volatile solid-state storage. The method includes writing each of the plurality of portions of user data to the non-volatile solid-state storage such that each of the plurality of portions of user data is identified and locatable for reading via the one of the plurality of sequential, nonrepeating addresses of the address space.

Abstract: A self-learning translation-engine brokering system characterizes a set of language-translation engines by associating each engine with values of a set of engine parameters. The system receives a request to translate text or speech input, along with a set of weightings that identify the relative importance of each engine parameter to the translation requester. The system formats the input into a quantifiable engine-agnostic form and performs an optimization procedure that finds the best fit between the source's weightings and the sets of engine parameters. The system directs the input to the best-fitting translation engine, receives the translated output from the selected engine, directs the output to the translation requester, and then determines how well the translated output meets user expectations. This feedback used to update the best-fitting engine's parametric values and to train the system to make more accurate selections in the future.

Abstract: Intervertebral devices and systems, and methods of their use, are disclosed having configurations suitable for placement between two adjacent vertebrae, replacing the functionality of the disc therebetween. Intervertebral devices and systems contemplated herein are implantable devices intended for replacement of a vertebral disc, which may have deteriorated due to disease for example. The intervertebral devices and systems are configured to allow for ample placement of therapeutic agents therein, including bone growth enhancement material, which may lead to better fusion between adjacent vertebral bones. The intervertebral devices and systems are configured for use in minimally invasive procedures, if desired.

Abstract: A method of applying a data format in a direct memory access transfer is provided. The method includes distributing user data throughout a plurality of storage nodes through erasure coding, wherein the plurality of storage nodes are housed within a single chassis that couples the storage nodes as a cluster, each of the plurality of storage nodes having nonvolatile solid-state memory for user data storage. The method includes reading a self-describing data portion from a first memory of the nonvolatile solid-state memory and extracting a destination from the self-describing data portion. The method includes writing data, from the self-describing data portion, to a second memory of the nonvolatile solid-state memory according to the destination.

Abstract: A method of treating a reservoir penetrated by at least one well is provided. In accordance with the method, a consolidated solids pack is placed into a permeable zone of rock in the reservoir. The consolidated solids pack has a reduced permeability to water and a reduced mobility in the permeable zone. For example, when placed in the permeable zone in connection with a water flooding operation, the consolidated solids pack diverts the injectant from the permeable zone to other less permeable zones of the reservoir that contain oil.

Abstract: In one embodiment, a method includes determining television content that a particular user is currently watching on a television. The method further includes determining, using one or more of a plurality of sensors, an attention level for the particular user. The attention level indicates an amount of attention paid by the particular user to the television content on the television. The method further includes determining, using one or more of the plurality of sensors, demographic information for the particular user. The method further includes storing the determined demographic information for the particular user and the particular user's attention level for the television content in the storage media.

Abstract: According to one or more embodiments of the present invention, a delay circuit includes a first sub-circuit that delays a leading edge of an input signal according to first control settings, the input signal being for an electric device. The delay circuit further includes a second sub-circuit that delays a trailing edge of the input signal according to second control settings. An output signal from the delay circuit is received by the electric device.

Abstract: A platform comprises one or more sensors that collect information about an environment as sensor data. A processor is in communication with the one or more sensors, wherein the processor executes enhancement engines that processes the sensor data into enhanced characterization data having a reduced amount of data compared to the sensor data. An output device electronically communicate the enhanced characterization data to a user, wherein the sensor and the output device comprise an assisted perception module worn by the user during an incident. A command interface device remote from the user to enable a person of authority to manage the incident and the user by receiving and displaying the enhanced characterization data, and by transmitting data and commands back to the assisted perception module.

Abstract: A method of applying an address space to data storage in a non-volatile solid-state storage is provided. The method includes receiving a plurality of portions of user data for storage in the non-volatile solid-state storage and assigning to each successive one of the plurality of portions of user data one of a plurality of sequential, nonrepeating addresses of an address space. The address range of the address space exceeds a maximum number of addresses expected to be applied during a lifespan of the non-volatile solid-state storage. The method includes writing each of the plurality of portions of user data to the non-volatile solid-state storage such that each of the plurality of portions of user data is identified and locatable for reading via the one of the plurality of sequential, nonrepeating addresses of the address space.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

Abstract: A process is provided for the preparation of lacing resistant, titanium dioxide particles for use in photodurable thin film production. Said process involves dewatering titanium dioxide particles that have been encapsulated with a layer of amorphous alumina in continuous fashion at temperatures in excess of 100° C.

Abstract: A midsole for a shoe, where the midsole is 3D printed from an elastic polymeric material, the midsole comprising: a sole facing surface, a foot facing surface, a plurality of walls that in a first position are substantially perpendicular to the sole facing surface that extend from the sole facing surface to the foot facing surface where each wall has a height, where the plurality walls define a plurality of cells having a central axis that is substantially parallel to the walls and having a radius from a wall to the central axis, where the walls in a second position are configured to elastically deform upon application of an external force so that the deformation provides a change in the radius and/or the height, and where the walls are adapted to return to their first position upon removal of the external force

Abstract: Intervertebral devices and systems, and methods of their use, are disclosed having configurations suitable for placement between two adjacent vertebrae, replacing the functionality of the disc therebetween. Intervertebral devices and systems contemplated herein are implantable devices intended for replacement of a vertebral disc, which may have deteriorated due to disease for example. The intervertebral devices and systems are configured to allow for ample placement of therapeutic agents therein, including bone growth enhancement material, which may lead to better fusion between adjacent vertebral bones. The intervertebral devices and systems are configured for use in minimally invasive procedures, if desired.

Abstract: Dynamically forming a failure domain in a storage system that includes a plurality of blades, each blade mounted within one of a plurality of chassis, including: identifying, in dependence upon a failure domain formation policy, an available configuration for a failure domain that includes a first blade mounted within a first chassis and a second blade mounted within a second chassis, wherein each chassis is configured to support multiple types of blades; and creating the failure domain in accordance with the available configuration.

Abstract: A technique relates to computer artifacts in a computer system. The technique includes creating a list of insights from artifacts, determining a similarity level between the insights of the artifacts and a predefined area of capability, comparing similarity level of insights for each of the artifacts to a threshold metric, removing artifacts having the similarity level below threshold metric such that artifacts remaining meet the threshold metric, and performing a pair-wise similarity comparison on the artifacts remaining which compares insights of the artifacts to each other to determine which ones are least common. The technique includes creating feature vectors for artifacts that are least common, determining a feature vector having a most variation in feature vectors, an artifact associated with the feature vector being determined to comprise a unique insight, and generating a unique message using the artifact associated with the feature vector being the unique insight.