Abstract: The invention relates to a compound which is (S)-4-((S)-3-Fluoro-3-(2-(5,6,7,8-tetrahydro-1, 8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy)phenyl) butanoic acid (1:1) citrate salt, pharmaceutical compositions including such compound, and to the use of such compound in therapy, including in the treatment of a disease or condition for which an ?vJ36 integrin antagonist is indicated, and in particular idiopathic pulmonary fibrosis.

Abstract: A method and system for optimization of an advertisement in a network resource in a proxy server of a cloud-based proxy service are described. Responsive to determining that there is an advertisement element in a network resource, the proxy server automatically modifies the advertisement element. The automatic modification of the advertisement element includes: 1) compressing style code into compressed style code; 2) compressing the image; and 3) compressing the style generation code. The proxy server generates a modified version of the network resource including the modified version of the advertisement element, where the modified version of the advertisement element is smaller in size than the advertisement element included in the network resource retrieved from the origin server; and transmits the modified version of the network resource to the client device instead of the network resource.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: A method and system for dynamically optimizing a script library are described. A request for a script library is received from a set of client devices. An instrumented version of the script library is transmitted to at least one of the set of client devices. The instrumented version of the script library includes code for tracing execution of the script library. Responsive to execution of the instrumented version of the script library at each one of the at least one of client devices, script library usage feedback indicative of usage of the script library at these client devices is received. An optimized version of the script library, generated based on the script library usage feedback by removing portions of the script library that are unused by the subset of client devices, is transmitted to the client device instead of the script library in response to a second request.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: A compound according to formula (I) wherein R1 is hydrogen, cyclopropyl, or pyrazolyl, wherein said pyrazolyl is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof.

Abstract: A compound according to formula (I) wherein R1 is hydrogen, cyclopropyl, or pyrazolyl, wherein said pyrazolyl is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof.

Abstract: A compound of formula (I) or a salt thereof: wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono- or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono- or di-substituted pyrazole, Ri does not represent 3,5-Dimethyl-1H-pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1-yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl.

Abstract: A set of dies for embossing or debossing is disclosed. The set has a female die (4, 80) and a male die (7, 67) each which has a steel backing plate (5, 47, 75). One of the dies is strongly magnetically attracted to a base plate (1, 68) which results in a weak magnetic attraction between the two dies (4, 7 or 67, 80). The weak magnetic attraction enables the set of dies to be substantially automatically self-aligning. Furthermore, such a set of dies can be used with a cutting and creasing die (50) to permit embossing or debossing simultaneously with cutting and/or folding during the same run.

Abstract: A connector for interconnecting or mutually isolating two or more electrical circuits is provided. The connector comprises first and second inter-engageable connector parts. A first part comprises a spigot and first contact pins for connection to an electrical circuit. The second connector part comprises a socket and second contact pins for connection to an electrical circuit. The second part has a lock ball projecting into the socket. The first part defines a groove for receipt of the lock ball. The first contact holder has a first shroud disposed around the first contact pins. The first shroud extends beyond the first contact pins. The second contact holder has second shrouds disposed around the each second contact pin. The second shrouds extends beyond the second contact pins. The contact holders are arranged such that when the spigot is received in the socket, the connector parts are moveable between a first position and a second position.

Abstract: A linear actuator such as a hydraulic cylinder has linear position sensing apparatus. At least one magnet is provided in a recess in outer surface of the piston for generating a magnetic field that passes through the wall of the cylinder housing. A magnetic sensor arrangement determines the axial position of the piston relative to the housing and comprises at least a pair of magnetic sensor elements arranged at spaced apart locations along the external surface of the wall for sensing the strength of the magnetic field passing through the wall of the housing. The recess in the piston is axially positioned between the first and second end surfaces of the piston and the at least one magnet is disposed between axially spaced north and south pole pieces.

Abstract: A connector for interconnecting or mutually isolating two or more electrical circuits is provided. The connector comprises first and second inter-engageable connector parts. A first part comprises a spigot and first contact pins for connection to an electrical circuit. The second connector part comprises a socket and second contact pins for connection to an electrical circuit. The second part has a lock ball projecting into the socket. The first part defines a groove for receipt of the lock ball. The first contact holder has a first shroud disposed around the first contact pins. The first shroud extends beyond the first contact pins. The second contact holder has second shrouds disposed around the each second contact pin. The second shrouds extends beyond the second contact pins. The contact holders are arranged such that when the spigot is received in the socket, the connector parts are moveable between a first position and a second position.

Abstract: This invention relates to a computer-based method and system for facilitating the classification of information items. Information items are searched for references to entities of interest, and associated with such entities based on calculated confidence levels that the information items contains a reference to the entities and a category confidence level that the information items relate to the entities.

Abstract: A control actuation system for an air-breathing rocket motor propelled guided missile positions the drive motors and input gears in an inlet fairing extending aft of the air inlet towards the tail of the missile. The output gears are positioned coincident with and mechanically coupled to their respective tail fins spaced around the circumference of the missile. At least one of the tail fins is offset in a circumferential direction of the missile from its corresponding input gear and the inlet fairing. At least one ring gear is positioned around the exhaust tube to rotate in the circumferential direction of the missile. The ring gear comprises input and output teeth that engage the input and output gears, respectively, to actuate the tail fin.

Abstract: A control actuation system for an air-breathing rocket motor propelled guided missile positions the drive motors and input gears in an inlet fairing extending aft of the air inlet towards the tail of the missile. The output gears are positioned coincident with and mechanically coupled to their respective tail fins spaced around the circumference of the missile. At least one of the tail fins is offset in a circumferential direction of the missile from its corresponding input gear and the inlet fairing. At least one ring gear is positioned around the exhaust tube to rotate in the circumferential direction of the missile. The ring gear comprises input and output teeth that engage the input and output gears, respectively, to actuate the tail fin.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.

Abstract: A photopolymer die for foil stamping, foil printing, embossing, debossing, or a combination thereof is disclosed. The die has a metal backing plate on which is mounted a photopolymer layer which has a number of micro-grooves therein. Preferably the micro-grooves are arranged in a swatch like pattern. Preferably images have adjacent regions each with a different pattern of micro-grooves. The spacing between adjacent micro-grooves can be resolvable by the human eye, or cannot.

Abstract: A set of dies for embossing or debossing is disclosed. The set has a female die (4, 80) and a male die (7, 67) each which has a steel backing plate (5, 47, 75). One of the dies is strongly magnetically attracted to a base plate (1, 68) which results in a weak magnetic attraction between the two dies (4, 7 or 67, 80). The weak magnetic attraction enables the set of dies to be substantially automatically self-aligning. Furthermore, such a set of dies can be used with a cutting and creasing die (50) to permit embossing or debossing simultaneously with cutting and/or folding during the same run.