Abstract: A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.

Abstract: An information marketplace is provided in which information items are received from various sources. Each item and the item providers carry descriptors that identify various attributes of the information being provided and by whom it is being provided. Requests for information are received from information consumers that are also tagged with attributes describing the consumer and the information being requested. A subset of the information available in the marketplace is provided to the consumer based on a degree of match among the characteristics describing the information, the attributes associated with the provider of the information, and the attributes associated with the consumer without identifying the actionable investment opportunity to the information consumer or identifying the information consumer to the information provider.

Abstract: A linear actuator such as a hydraulic cylinder has linear position sensing apparatus. At least one magnet is provided in a recess in outer surface of the piston for generating a magnetic field that passes through the wall of the cylinder housing. A magnetic sensor arrangement determines the axial position of the piston relative to the housing and comprises at least a pair of magnetic sensor elements arranged at spaced apart locations along the external surface of the wall for sensing the strength of the magnetic field passing through the wall of the housing. The recess in the piston is axially positioned between the first and second end surfaces of the piston and the at least one magnet is disposed between axially spaced north and south pole pieces.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.

Abstract: The present invention is directed to compounds of formula (I): wherein R represents a methyl or an ethyl group X represents N, C—H or C—CH3 when X represents C—H or C—CH3, Y represents N when X represents N, Y represents C—H and physiologically functional derivatives thereof, pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.

Abstract: This invention relates to a computer-based method and system for facilitating the retrieval, classification, and distribution of information. In one embodiment, a method for providing information comprises providing a plurality of entities, each having an entity type, providing a plurality of relationships among the entities, each relationship having a relationship type and direction, and constructing an entity-relationship network comprising the entities and relationships. The method further includes receiving a plurality of information items, facilitating the association of the information items with at least one corresponding entity, receiving a request for information items associated with a selected one of the entities, determining a subset of the entities based on the selected entity, the relationships, the relationship types and the relationship directions, and providing the information items associated with the subset of the entities.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.

Abstract: The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.

Abstract: This invention relates to a computer-based method and system for facilitating the retrieval, classification, and distribution of information. In one embodiment, a method for providing information comprises providing a plurality of entities, each having an entity type, providing a plurality of relationships among the entities, each relationship having a relationship type and direction, and constructing an entity-relationship network comprising the entities and relationships. The method further includes receiving a plurality of information items, facilitating the association of the information items with at least one corresponding entity, receiving a request for information items associated with a selected one of the entities, determining a subset of the entities based on the selected entity, the relationships, the relationship types and the relationship directions, and providing the information items associated with the subset of the entities.

Abstract: A universal mounting bracket tightly attaches display hooks having a common base to a display structure, thereby restraining movement of the display hook relative to the display structure. The mounting bracket includes a mounting member having a feature that cooperates with a complimentary feature on the common base to mount the display hook onto the mounting bracket, an engaging member for engaging the mounting member with the display structure, and a securing member for securing the mounting member against the display structure. The mounting member may include a plate with an outer periphery having a rib that is received within a groove formed in the common base in an interference fit, and the securing member may include an adjustment guide and an adjustment element configured for guided movement relative to the adjustment guide in a direction generally perpendicular to a plane defined by the plate of the mounting member.

Abstract: A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.

Abstract: A compound of formula (I): is claimed wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; R1 represents phenyl, pyridyl or thienyl wherein the phenyl group may be optionally substituted by one or two groups independently selected from fluorine, cyano, —C(O)OCH3 and —C(O)OCH2CH3, and the pyridyl group may be optionally substituted by one fluorine group; and R2 represents methyl or ethyl; along with physiologically functional derivatives thereof, pharmaceutical compositions and formulations thereof, combinations thereof, methods of treatment employing such compounds and processes for preparing the compounds.

Abstract: An information marketplace is provided in which information items are received from various sources. Each item and the item providers carry descriptors that identify various attributes of the information being provided and by whom it is being provided. Requests for information are received from information consumers that are also tagged with attributes describing the consumer and the information being requested. A subset of the information available in the marketplace is provided to the consumer based on a degree of match among the characteristics describing the information, the attributes associated with the provider of the information, and the attributes associated with the consumer without identifying the actionable investment opportunity to the information consumer or identifying the information consumer to the information provider.

Abstract: A compound of formula (I): wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; and R1 and R2 each independently represent hydrogen, fluorine or chlorine; or a physiologically functional derivative thereof.

Abstract: This invention relates to a computer-based method and system for facilitating the classification of information items. Information items are searched for references to entities of interest, and associated with such entities based on calculated confidence levels that the information items contains a reference to the entities and a category confidence level that the information items relate to the entities.

Abstract: Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.

Abstract: Compounds of formula (I), methods for their preparation and their use in the manufacture of neuraminidase inhibitor conjugates.

Abstract: The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which binds to the active site of influenza virus neuraminidase, but is not cleaved by the neuraminidase. The invention also relates to processes for the preparation of the multimeric compound defined above, pharmaceutical compositions containing them or methods for the treatment and/or prophylaxis of a viral infection involving them.

Abstract: This invention relates to a computer-based method and system for facilitating the retrieval, classification, and distribution of information. In one embodiment, a method for retrieving information includes defining command strings that include a URL and a token in a first software application, identifying a value for the token based on a research topic provided by a user, replacing the token in the command strings with the identified value, and transmitting the command strings to instantiations of a second software application, thereby allowing the instantiations of the second software application to retrieve data using its respective command string.