Abstract: Methods and compositions for increasing the efficacy of an agent that directly or indirectly affects a muscarinic receptor by administering a pyrophosphate analog. Methods and compositions for protecting a pharmacological agent in a formulation, comprising combining the pharmacological agent with at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of a neurologic agent by administering at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of an agent that neither directly nor indirectly affects a muscarinic receptor by administering at least one pyrophosphate analog.

Abstract: Methods and compositions for protecting and treating a muscarinic receptor in an animal or plant from bacterial, fungal, algo or algae infections through administration of at least one pyrophosphate analog.

Abstract: Methods and compositions for protecting muscarinic receptor(s) in a subject from at least one carcinogenic or toxic metal by administration of a pyrophosphate analog. Methods and compositions for preventing at least one disease induced or caused by metals compromising the function of muscarinic receptors in a subject by administration of a pyrophosphate analog. Methods and compositions for reducing toxic action of metal ions and for reducing poisoning by metals by administering a pyrophosphate analog.

Abstract: Methods and compositions for protecting muscarinic receptor(s) in a subject by administering at least one protective agent alone, in combination with other protective agents, or in combination with at least one neurologic agent.

Abstract: Methods and compositions for protecting and treating a muscarinic receptor in a subject in need thereof from dysfunction not resulting from oxidative stress, toxic actions of metals or metal ions, or infectious agents by administering a pyrophosphate analog.

Abstract: This invention relates to a computer-based method and apparatus for facilitating the retrieval, classification, and distribution of information. In one embodiment, a method for providing information relating to a topic comprises specifying a first and second topic, specifying a relationship between the two topics, receiving a first and second piece of information, associating the first piece of information with the first topic and the second piece of information with the second topic, requesting information associated with the first topic, and receiving the information associated with the first and second topics.

Abstract: This invention relates to a computer-based method and system for facilitating the retrieval, classification, and distribution of information. In one embodiment, a method for providing information comprises providing a plurality of entities, each having an entity type, providing a plurality of relationships among the entities, each relationship having a relationship type and direction, and constructing an entity-relationship network comprising the entities and relationships. The method further includes receiving a plurality of information items, facilitating the association of the information items with at least one corresponding entity, receiving a request for information items associated with a selected one of the entities, determining a subset of the entities based on the selected entity, the relationships, the relationship types and the relationship directions, and providing the information items associated with the subset of the entities.

Abstract: Compounds of formula (I) 1

Abstract: The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which binds to the active site of influenza virus neuraminidase, but is not cleaved by the neuraminidase. The invention also relates to processes for the preparation of the multimeric compound defined above, pharmaceutical compositions containing them or methods for the treatment and/or prophylaxis of a viral infection involving them.

Abstract: According to the invention are provided compounds of formula (I) (relative stereochemistry indicated) wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) are useful inter alia in the treatment of inflammatory diseases of the respiratory tract.

Abstract: There are described according to the invention, processes for making compounds of formula (XXVIII)3 (relative stereochemistry indicated), wherein P2 is as defined in the specification.

Abstract: According to the invention there are provided Hexahydro-Pyrrolo[3,4-b]pyrrol-2-one compounds of formula (1), (relative stereochemistry indicated), wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (1) are useful inter alia in the treatment or chronic bronchitis.

Abstract: There are described according to the invention, compounds of formula (XXII).sup.a (relative stereochemistry indicated), wherein R.sub.2 is as defined in the specification. Compounds of formula (XXII).sup.a are useful as intermediates in the production of pharmaceuticals useful in the treatment of chronic bronchitis.

Abstract: There are described according to the invention compounds of formula (I) (relative stereochemistry indicated), wherein R.sub.1, R.sub.2, R.sub.3 and X are as defined in the specification, together with processes for preparing them, compositions containing them and their use as pharmaceuticals. Compounds of formula (I) are indicated inter alia for the treatment of chronic bronchitis.

Abstract: A magnetic holding device comprises a housing (2) and includes a number of magnetic regions. Each magnetic region has a rare earth or bimetallic disc magnet (9) and a ferromagnetic plate (10) located within an aperture within the housing (2). A filling material (11) surrounds both the magnet (9) and disc (10).

Abstract: An insert moulding system in which a movably mounted tool head loads inserts into the mould and unloads moulded articles from the mould. The tool head has sensors and an article position and retaining structure on a load face thereof for each of a number of insert pieces to be incorporated in the moulded articles. The operation is computer controlled and the sensors on the tool head sense at least one characteristic of each insert piece thereon, e.g. flatness and generate a signal in response to such characteristic being outside of specification which renders inoperative the moulding process until the offending insert piece is replaced by one meeting specification. Position locators have inter-engageable portions respectively on the tool head and the fixed in position mould positively to locate the movable head and fixed mould in a predetermined fixed relation relative to one another during cycle after cycle of operation providing precision injection moulding.