Abstract: Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoin-dolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

Abstract: Integrated heat spreaders having electromagnetically-formed features, and semiconductor packages incorporating such integrated heat spreaders, are described. In an example, an integrated heat spreader includes a top plate flattened using an electromagnetic forming process. Methods of manufacturing integrated heat spreaders having electromagnetically-formed features are also described.

Abstract: The present invention provides apparatus for transferring a load, comprising at least one unitary element of adsorptive material that increases an effective working volume of an enclosure for containing a pressurised gas that transfers a load between a first load transfer element and a further load transfer element. Use of at least one unitary element of adsorptive material is also provided to increase an effective working volume of an enclosure for containing a pressurised gas that transfers a load between a first load transfer element and a further load transfer element. A method of transferring a load is also provided.

Abstract: A dialysis catheter is provided. A first lumen extends through a first tubular member from a proximal portion to a distal portion, and a first orifice at the distal portion provides an opening through the first tubular member to the first lumen. The first tubular member further includes an inflation lumen extending longitudinally at least partially through a length of the first tubular member. A balloon is operably connected to an outer surface of the first tubular member proximal to the first opening, is in fluid communication with the inflation lumen. A second tubular member has a proximal portion connected to the outer surface of the first tubular member. A distal portion of the second tubular member is connected to the balloon wall. A second lumen extends through the second tubular member, and a second orifice provides an opening through the second tubular member at the distal portion.

Abstract: An apparatus (112, 113) that provides pressurised gas to at least one target location (124), comprising at least one region of adsorptive material that increases an effective storage volume of at least one pressurised gas storage container in selective fluid communication with at least one target location, wherein pressurised gas is stored in the container at a positive pressure of about around 0.5 MPa to 4 MPa. The invention also relates to a method of providing pressurised gas to at least one target location (124) such as a pneumatic system in a vehicle.

Abstract: The present invention provides a sound attenuating apparatus including a substrate element comprising at least one first heterogeneous material, and at least one region comprising at least one further heterogeneous material at least partially located in the substrate element, wherein the at least one further heterogeneous material has at least one more scale of heterogeneity than the at least one first heterogeneous material. The present invention provides a method and apparatus for attenuating sound through a cavity construction in buildings and vehicles or the like, wherein the method comprises locating at least one region of adsorptive material in a cavity defined between a first wall region and a further wall region to attenuate sound transmission across the wall regions.

Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

Abstract: Described is a device (410) for use in removing a conveyance member from a material. The device (410) includes a displacement element (412) for being placed at least partly around a conveyance member and for displacing material as the device is advanced along a conveyance member. The device (410) also includes a driven component for receiving a driving force for driving the device through material. The device can include a coupling element (418) for coupling the device to a shaft and a material loosener (414) including a drilling element. The material loosener can be operable to loosen material ahead of the displacement element as the device is advanced along a conveyance member. The drilling element can be coupled to a first wheel (436) and the coupling element can include a second wheel (434) cooperating with the first wheel to transfer rotational movement of a shaft to the drilling element.

Abstract: Generating and utilizing personalized predictive models are provided. When an electronic input is received, a generic predictive model is used to predict a user response to the input. After a prescribed period of time, an analysis is performed to determine the user's actual response to the input, as well as, the user's actual responses to other inputs of the same type. Training is performed on the generic predictive model to generate a new and personalized predictive model based on the user's actual responses to the analyzed inputs. The personalized predictive model is then utilized for predicting user response to future inputs of the same type. At a prescribed frequency, the generated personalized predictive model is updated by analyzing actual user responses to predictions provided by the personalized predictive model.

Abstract: An apparatus for enrollment and verification of a user comprising one touch two factor biometric sensors. An enrollment process creates the baseline abstract identity information for the user. Subsequent verification processes capture new abstract identity information to be matched to the baseline on an encrypted server. A first camera takes a first surface image of a portion of a user's finger to capture the pattern of friction ridges and valleys and intersection points. A second camera takes a second subsurface image of a vein map below the surface of the user's finger. These are then fused into a binary format that cannot be reversed to reacquire either the fingerprint or the vein map. The enrollment data and the verification data are then compared to each other in order to determine if they match for authentication of the user.

Abstract: There is provided an air spring for supporting a load, the air spring comprises a chamber for holding a pressurised gas in use, a load-bearing surface arranged to transmit a force from a load in use to the pressurised gas held in the chamber. Importantly, in order to lower the spring rate, the chamber contains a mass of adsorptive material. There is also provided a use of an adsorptive material for the purpose of lowering the spring rate of an air spring, including a gas strut and a pneumatic wheel. There is also provided a method of designing an air spring using an adsorptive material to lower the spring rate.

Abstract: A portable ion mobility spectrometry apparatus (1) for detecting an aerosol and a method for using the apparatus. The apparatus comprises an ion mobility spectrometer (3); a portable power source (5) carried by the apparatus for providing power to the apparatus (1); an inlet (7) for collecting a flow of air to be tested by the spectrometer (3); a heater (4) configured to heat the air to be tested to vapourise an aerosol carried by the air and a controller (2) configured to control the spectrometer (3) to obtain samples from the heated air, wherein the controller is configured to increase a heat output from the heater (4) for a selected time period before obtaining samples from the heated air.

Abstract: An electro discharge machining apparatus comprises an electrode configured to machine a desired feature in a workpiece, a pulse generator configured to energize the electrode and the workpiece to opposite electrical polarities, a machining solution source configured to pass a machining solution between the electrode and the workpiece, and a servomotor configured to drive the electrode to move relative to the workpiece. The electro discharge machining apparatus further comprises at least one detection element configured to detect machining signals, and a controller. The controller controls the pulse generator and the servomotor to machine the workpiece according to a plurality of first process parameters predetermined therein and analyzes the detected machining signals to generate a first response signal to activate a plurality of second process parameters predetermined therein and different from the first process parameters to machine the workpiece. An electro discharge machining method is also presented.

Abstract: A decal assembly applied to a finished wood floor comprising a visible layer, a clear layer adhered to the visible layer, and a floor finish layer, wherein an outer surface of the floor finish has a coefficient of friction similar to the finished wood floor. The floor finish may be water-based or oil-based and the decal assembly may include an adhesion promotion layer disposed between the clear layer and the floor finish layer. The decal assembly may also include the clear layer having a roughened outer surface. The decal may be installed on a wood floor by laminating a clear layer to a visible layer, roughening an outer surface of the clear layer and applying a floor finish to the outer surface of the clear layer after the roughening step. An adhesion promotion layer may also be applied between the clear layer and the floor finish layer.

Abstract: A method is disclosed for characterizing a first data set of digital values and a second data set of digital values. The method includes determining a first similarity measure indicating a similarity of the digital values within the first data set; determining a second similarity measure indicating a similarity of the digital values within the second data set; determining a correlation value on the basis of the first data set and the second data set; and electronically outputting the correlation value, the first similarity measure and the second similarity measure.

Abstract: Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoin-dolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof.

Abstract: Various embodiments include apparatuses and systems for controlling compressor clearances. In one case, an apparatus includes: a material layer sized to fit a case of a gas turbine (GT) compressor in a GT system, the material layer including a heating element for applying heat to the case of the GT compressor; and a control system coupled with the material layer, the control system configured to: determine whether a shutdown sequence is occurring in the GT system; and actuate the heating element to apply heat to the case of the GT compressor in response to determining that the shutdown sequence is occurring.

Abstract: Guaranteeing space availability for thin devices includes reserving space without committing, or fully pre-allocating, the space to specific thin device ranges. Space may be held in reserve for a particular set of thin devices and consumed as needed by those thin devices. The system guards user-critical devices from running out of space, for example due to a “rogue device” scenario in which one device allocates an excessive amount of space. The system uses a reservation entity, to which a thin device may subscribe, which reserves space for the thin device without allocating that space before it is need to service an I/O request.

Abstract: An on-demand vapour generator includes a vapour chamber configured to produce a vapour and a vapour absorption assembly configured to receive flows of vapour from the vapour chamber. The vapour absorption assembly includes a first vapour-permeable passage having a passage outlet and at least one second vapour-permeable passage that is closed. When vapour absorption assembly receives a flow of vapour from the vapour chamber, the flow of vapour passes through the first vapour-permeable passage to the passage outlet at least substantially without absorption of vapour from the flow of vapour. However, when a flow of vapour is not received from the vapour chamber, vapour entering the vapour absorption assembly from the vapour chamber passes into the first vapour-permeable passage and the at least one second vapour-permeable passage and is at least substantially absorbed.