Patents by Inventor John G. Baust

John G. Baust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10336984
    Abstract: A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Several additive agents (both natural and synthetic) have been identified, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: July 2, 2019
    Assignee: CPSI Holdings LLC
    Inventors: John M. Baust, John G. Baust, William L. Corwin, Robert G. Van Buskirk
  • Patent number: 10182859
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic probe.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: January 22, 2019
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Patent number: 9974592
    Abstract: Cryogenic medical devices and apparatus are disclosed which are capable of generating cryogen to a supercritical state, specifically supercritical nitrogen. The cryogenic medical devices and apparatus disclosed are useful in methods of treating damaged, diseased, cancerous or other unwanted tissues.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: May 22, 2018
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Melissa K. Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 9932551
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 3, 2018
    Assignee: CPSI Holdings LLC
    Inventors: John G. Baust, Joshua T. Smith, Kimberly L. Santucci, Kristi K. Snyder, Anthony T. Robilotto, Robert G. Van Buskirk, John M. Baust, William L. Corwin, Jennie F. McKain
  • Publication number: 20170224401
    Abstract: A cryogenic medical device is disclosed for use in minimally invasive surgical procedures. Various configurations of cryoprobes are designed in combination with a clamp to form a cryoclamp for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is an integrated cryoablation probe with a hinged clamp that allows for single entry into the chest cavity through a thorascopic port, by surgical or other means. The integrated cryoablation probe allows for the clamping of tissue as well as freezing with a single device. The clamp acts as an outer sheath so that when closed, directional freezing of the cryoprobe is achieved on the opposing probe surface away from the clamp or on an internal surface that is between the clamp. The cryoclamp may be a removable attachment or integrated into the unitary device.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 10, 2017
    Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Anthony Robilotto
  • Publication number: 20170191011
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Inventors: John G. BAUST, Joshua T. SMITH, Kimberly L. SANTUCCI, Kristi K. SNYDER, Anthony T. ROBILOTTO, Robert G. VAN BUSKIRK, John M. BAUST, William L. CORWIN, Jennie F. MCKAIN
  • Publication number: 20170172791
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.
    Type: Application
    Filed: February 28, 2017
    Publication date: June 22, 2017
    Inventors: John M. Baust, Roy E. Cheeks, John G. Baust, Anthony Robilotto, Kristi K. Snyder
  • Patent number: 9631173
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: April 25, 2017
    Assignee: CPSI Holdings LLC
    Inventors: John G. Baust, Joshua T. Smith, Kimberly L. Santucci, Kristi K. Snyder, Anthony T. Robilotto, Robert G. Van Buskirk, John M. Baust, William L. Corwin, Jennie F. McKain
  • Publication number: 20160338754
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
    Type: Application
    Filed: August 5, 2016
    Publication date: November 24, 2016
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Patent number: 9408654
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: August 9, 2016
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Publication number: 20160068804
    Abstract: A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and/or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery.
    Type: Application
    Filed: August 6, 2015
    Publication date: March 10, 2016
    Inventors: John M. Baust, John G. Baust, William L. Corwin, Robert G. Van Buskirk
  • Publication number: 20160060592
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Application
    Filed: November 6, 2015
    Publication date: March 3, 2016
    Inventors: John G. BAUST, Joshua T. SMITH, Kimberly L. SANTUCCI, Kristi K. SNYDER, Anthony T. ROBILOTTO, Robert G. VAN BUSKIRK, John M. BAUST, William L. CORWIN, Jennie F. MCKAIN
  • Publication number: 20160022345
    Abstract: Cryogenic medical devices and apparatus are disclosed which are capable of generating cryogen to a supercritical state, specifically supercritical nitrogen. The cryogenic medical devices and apparatus disclosed are useful in methods of treating damaged, diseased, cancerous or other unwanted tissues.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 28, 2016
    Inventors: John M. Baust, John G. Baust, Roy E. Cheeks, Melissa K. Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 9213025
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: December 15, 2015
    Assignee: CPSI Holdings LLC
    Inventors: John G. Baust, Joshua T. Smith, Kimberly L. Santucci, Kristi K. Snyder, Anthony T. Robilotto, Robert G. Van Buskirk, John M. Baust, William L. Corwin, Jennie F. McKain
  • Publication number: 20150257810
    Abstract: One embodiment of the invention is a flexible cryogenic probe tip. The flexible probe tip has a linear freeze zone at a distal end of the probe that allows for its placement and precisely controlled movements. The flexible cryogenic probe tip precisely conforms to the target tissue surface to create a linear lesion. In addition, the probe tip is steerable to facilitate proper placement with minimal access points into a patient's body. Various configurations of the flexible probe tip allow it to conform and ablate tissue of many sizes, shapes, and/or dimensions.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 17, 2015
    Inventors: John M. Baust, Claudia Luekge, Roy Cheeks, John G. Baust, Anthony T. Robilotto
  • Patent number: 9089316
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues, particularly as utilized for the ablation of cardiac tissue in the treatment of atrial fibrillation. The device is a closed or semi-closed system in which the liquid cryogen is nitrogen contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state, specifically supercritical nitrogen, and may be utilized in any rapid cooling systems. As designed, the device also integrates endocardial catheters and epicardial probes.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: July 28, 2015
    Assignee: Endocare, Inc.
    Inventors: John M Baust, John G. Baust, Roy E. Cheeks, Melissa K Dobson, Anthony T. Robilotto, Kristi K. Snyder, Robert G. Van Buskirk
  • Patent number: 8998888
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: April 7, 2015
    Assignee: Endocare, Inc.
    Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
  • Publication number: 20150018810
    Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 15, 2015
    Inventors: John M. Baust, Roy E. Cheeks, John G. Baust, Anthony Robilotto, Kristi K. Snyder
  • Publication number: 20140350537
    Abstract: Embodiments of the present invention relate to cryogenic systems and methods useful to cool objects, including living tissue, to freezing or cryogenic temperatures by placing the object in thermal communication with sub-cooled supercritical nitrogen.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 27, 2014
    Applicant: ENDOCARE, INC.
    Inventors: John G. Baust, John M. Baust, Anthony T. Robilotto
  • Publication number: 20140273063
    Abstract: A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: CPSI HOLDINGS LLC
    Inventors: John G. BAUST, Joshua T. SMITH, Kimberly L. SANTUCCI, Kristi K. SNYDER, Anthony T. ROBILOTTO, Robert G. VAN BUSKIRK, John M. BAUST, William L. CORWIN, Jennie F. MCKAIN