Patents by Inventor John G. Baust

John G. Baust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6921633
    Abstract: The invention provides methods for the hypothermic preservation of cells, tissues and organs. In particular, the invention provides methods for the hypothermic preservation or storage of cells, tissues or organs in the vitreous state.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: July 26, 2005
    Assignee: Biolife Solutions Incorporated
    Inventors: John M. Baust, John G. Baust, Robert VanBuskirk, Aby J. Mathew
  • Publication number: 20040096813
    Abstract: The invention provides methods for the hypothermic preservation of cells, tissues and organs. In particular, the invention provides methods for the hypothermic preservation or storage of cells, tissues or organs in the vitreous state.
    Type: Application
    Filed: November 18, 2002
    Publication date: May 20, 2004
    Applicant: BioLife Solutions, Inc.
    Inventors: John M. Baust, John G. Baust, Robert VanBuskirk, Aby J. Mathew
  • Publication number: 20030232396
    Abstract: The present invention is directed to systems and methods for assessing the success of the transplant of a cell, tissue, or organ before and after transplant. Protein array technology is used to obtain a biomarker pattern for the cell, tissue, or organ that is being considered for transplant or that has been transplanted. Samples for the identification of biomarkers and biomarker patterns are obtained from the cell, tissue or organ itself, or from a body fluid of the donor or recipient. Sample biomarker data are compared to reference biomarker data obtained from donors, recipients or cells, tissues or organs that have been transplanted. Correlation of a sample biomarker pattern with the reference biomarker pattern, where transplant outcome for the samples used for the reference biomarkers is known, permits a suggested treatment determination. A computerized system to identify the condition of transplant before or after implantation is also provided.
    Type: Application
    Filed: February 21, 2003
    Publication date: December 18, 2003
    Applicant: BioLife Solutions, Inc.
    Inventors: Aby J. Mathew, John M. Baust, Robert VanBuskirk, John G. Baust
  • Patent number: 6632666
    Abstract: Gel-based medium compositions and a method of use thereof in normothermic, hypothermic or cryopreservative storage and transport of cell samples are described. These gel-based compositions contain a cell maintenance and preservation medium together with a gelling agent. Such gel-based medium compositions protect various cell samples, such as animal or plant organs, tissues and cells, from the mechanical, physiological and biochemical stresses inherently associated with liquid preservation techniques.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: October 14, 2003
    Assignee: BioLife Solutions, Inc.
    Inventors: John M. Baust, Robert Van Buskirk, John G. Baust
  • Publication number: 20020172934
    Abstract: Gel-based medium compositions and a method of use thereof in normothermic, hypothermic or cryopreservative storage and transport of cell samples are described. These gel-based compositions contain a cell maintenance and preservation medium together with a gelling agent. Such gel-based medium compositions protect various cell samples, such as animal or plant organs, tissues and cells, from the mechanical, physiological and biochemical stresses inherently associated with liquid preservation techniques.
    Type: Application
    Filed: June 12, 2002
    Publication date: November 21, 2002
    Applicant: BioLife Solutions, Inc.
    Inventors: John M. Baust, Robert Van Buskirk, John G. Baust
  • Publication number: 20010049140
    Abstract: Gel-based medium compositions and a method of use thereof in normothermic, hypothermic or cryopreservative storage and transport of cell samples are described. These gel-based compositions contain a cell maintenance and preservation medium together with a gelling agent. Such gel-based medium compositions protect various cell samples, such as animal or plant organs, tissues and cells, from the mechanical, physiological and biochemical stresses inherently associated with liquid preservation techniques.
    Type: Application
    Filed: January 11, 2001
    Publication date: December 6, 2001
    Applicant: Biolife Solutions, Inc.
    Inventors: John M. Baust, Robert Van Buskirk, John G. Baust
  • Patent number: 6045990
    Abstract: Cell-free solution compositions for hypothermic cell storage supplemented with agents inhibiting apoptotic induced cell death are provided for chill preservation of cells at about 0.degree. C. to about 10.degree. C. Additionally, solutions for cell storage at hypothermic temperatures supplemented with cell death inhibitors for cryopreservation are disclosed. Methods for use of these solutions are described.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: April 4, 2000
    Inventors: John M. Baust, Robert G. Van Buskirk, John G. Baust, Mathew Aby
  • Patent number: 5916212
    Abstract: The present invention relates to a portable, hand held, self-contained cryosurgical probe system. In particular, the present invention relates to an improved portable, hand held cryosurgical probe system having easily changeable probes and cryogen sources wherein the cryogen can be provided in precharged cylinders mountable on the hand held unit and/or supplied from remote sources and which is capable of serving a plurality of probes via a multiprobe adapter. The present invention provides the flexibility of easily changeable probes and cryogen sources in a lightweight hand unit whereby different cryogens may be employed at different stages within a procedure or the cryogens may be mixed to vary the effective freeze capacity of the device.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: June 29, 1999
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G. Baust, John M. Baust, Lawrence Pottorf, Roy Cheeks, Hewu Ma, Chao-Min Zhang, Alan F. Rich, Richard J. Reinhart
  • Patent number: 5846235
    Abstract: A cryoprobe instrument for endoscopic use has been provided that permits the delivery of liquid or gaseous cryogens in the form of a spray. In an embodiment, the cryoprobe instrument includes an elongated, flexible tube having a fluid passage defined therethrough; a proximal connector portion provided at the proximal end of the tube for coupling the tube to a pressurized source of cryogenic refrigerant; and a nozzle tip mounted to the distal end of the tube. The nozzle tip has an outlet orifice constructed and arranged such that through the Joule-Thompson effect, cryogenic refrigerant exiting through the outlet orifice rapidly and substantially expands and cools.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: December 8, 1998
    Assignees: Johns Hopkins University, Cryomedical Sciences, Inc.
    Inventors: Pankaj Jay Pasricha, Anthony N. Kalloo, John G. Baust, Lawrence Potorff
  • Patent number: 5520682
    Abstract: A closed end surgical cryoprobe instrument may have a probe shaft diameter of 3 millimeters or less and can achieve and maintain freezing zone temperatures close to that of the liquid cryogenic refrigerant. Using sub-cooled liquid nitrogen at approximately -208.degree. C. freezing zone temperatures as low as -206.degree. C. can be achieved in under 1 minute. The liquid nitrogen supply tube is provided with a plurality of small vent holes to vent gas formed or present in the refrigerant supply tube to the return refrigerant flow channel. The vent holes also allow small amount of liquid nitrogen to vent into the return flow channel to further reduce the temperature differential between the sub-cooled liquid nitrogen supply and the counter current flowing return refrigerant. Heat transfer is maintained through nucleate boiling. In place of vent holes, narrow slits may be provided in the supply tube. Alternatively, a sintered porous metal supply tube can be used as the vent means.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: May 28, 1996
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G. Baust, ZhaoHua Chang, J. J. Finkelstein
  • Patent number: 5437673
    Abstract: The present invention is directed to a closed circulation tissue warming apparatus for use during surgery to maintain the temperature of tissues at a desired level and to a method of using the apparatus in prostate surgery particularly during transperineal cryoablation of the prostate gland in human males to maintain the temperature of the urethral tissues and thereby prevent urethral sloughing. It may also have utility where it is desired to lower the temperature of surrounding tissues, such as during laser ablation. The apparatus includes a multi-lumen catheter inserted into the urethra and connected to a fluid warming and circulation control means whereby warmed water is circulated through the lumens at a controlled flow rate and temperature. The concentric lumen structure of the catheter provides improved flow and even temperature maintenance along the length of the catheter and the urethra.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: August 1, 1995
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G. Baust, Zhao H. Chang, Jeffrey Cohen, Gary Onik, George Reyes
  • Patent number: 5254116
    Abstract: A closed end surgical cryoprobe instrument with probe shaft diameter of 3 millimeters or less is made to achieve and maintain freezing zone temperatures close to that of the liquid cryogenic refrigerant. Using sub-cooled liquid nitrogen at approximately -208.degree. C. freezing zone temperatures as low as -206.degree. C. can be achieved in under 1 minute. The liquid nitrogen supply tube is provided with a plurality of small vent holes to vent gas formed or present in the refrigerant supply tube to the return refrigerant flow channel. The vent holes also allow small amount of liquid nitrogen to vent into the return flow channel to further reduce the temperature differential between the sub-cooled liquid nitrogen supply and the counter-current flowing return refrigerant.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: October 19, 1993
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G. Baust, ZhaoHua Chang, J. J. Finkelstein
  • Patent number: 4155331
    Abstract: A method for the cryopreservation of multicellular organisms characterized by rapid cooling and warming rates, exceeding 100.degree. C. per minute, to achieve 80% survival after storage in the frozen state. The method involves exposing multicellular organisms to a cryoprotectant medium, freezing the organisms and medium by cooling at a rate greater than 100.degree. C. per minute, holding the organisms and medium at a point below 0.degree. C. for a period of time, and cooling the organisms and the medium at a rate greater than 100.degree. C. per minute to an appropriate storage temperature depending upon the desired length of the storage period. The method is more specifically described with regard to aquatic organisms, and particularly described with regard to the cryopreservation of immature marine crustaceans.
    Type: Grant
    Filed: April 1, 1977
    Date of Patent: May 22, 1979
    Inventors: Addison L. Lawrence, John G. Baust
  • Patent number: D406337
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: March 2, 1999
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G Baust, John M Baust, Lawrence Pottorf, Roy Cheeks, Hewu Ma, Chao-Min Zhang, Alan F. Rich, Richard J. Reinhart
  • Patent number: D414865
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: October 5, 1999
    Assignee: Cryomedical Sciences, Inc.
    Inventors: John G Baust, John M Baust, Lawrence Pottorf, Roy Cheeks, Hewu Ma, Chao-Min Zhang, Alan F. Rich, Richard J. Reinhart