Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: Systems, methods and apparatus for providing, operating, hosting and conducting a gaming application which uses selections by a participant in a fantasy gaming contest to identify the sportsbook proposition wagers most likely to be of interest to the participant and display the wagers to the participant through a user interface associated with the fantasy gaming contest user interface.

Abstract: Referring to FIG. 1. The invention relates to a housing for a soft pack dispensing container for wipes B, the latter featuring hermetically sealed edges 10, 11 and a rigid flip top A which has a frame fixed to the dispensing container B, a frame which surrounds an aperture 7 through which wipes are extracted. The fixed frame features at least two slide rails 3, 4 enabling the dispensing container A to attach to the supports within a housing so long as at least one of the slide rails 3, 4 is of a specific geometric cross section profile that corresponds to the geometric cross section profile of its corresponding support.

Abstract: A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.

Abstract: A pencil beam system includes a charged particle beam generator, a transport beamline apparatus, a scan nozzle, a fast deflector electromagnet, and a controller. After a therapeutic dose is delivered to a first target spot, the fast deflector electromagnet generates a first magnetic field that causes the net deflection of the charged particle beam to transition from the first target spot to an adjacent target spot. After the charged particle beam is directed to the adjacent target spot, the controller simultaneously adjusts the first magnetic field and the scan nozzle magnetic field to reduce and eliminate the contribution of the first magnetic field to the net deflection. The fast deflector electromagnet is deliberately designed with limited magnetic field and limited deflecting power to provide a higher slew rate, faster settling and less hysteresis contribution to beam position as compared to the scan nozzle electromagnets.

Abstract: A method is provided for detecting at least one fitness related activity is provided. Data is obtained from at least one sensor of a wearable device, wherein the at least one sensor detects the data based on at least one body movement of a user wearing the wearable device. Based on the obtained data, the at least one fitness related activity is detected from a set of fitness related activities, wherein the detection is performed without pre-training by the user for the detecting.

Abstract: Described are various embodiments of a computerized method and system for automatically developing a facial remediation protocol for a user based on an input facial image of the user, wherein facial remediation design or plan comprises a combination of one or more of a surgical plan to shift or change the size of various facial anatomical features, a makeup plan to change the apparent size or apparent position of various facial anatomical features and other techniques, such as hair design, to reduce the actual and perceived difference between the subject's face and a standard face, for example.

Abstract: A method of automatically controlling color of light in a room having one or more tintable windows, the method comprising determining adjustments in artificial interior lighting in the room to obtain a desired color of light and sending control signals over a communication network to adjust the artificial interior lighting, wherein the adjustments are determined based on a current tint state of each of the one or more tintable windows.

Abstract: The invention relates to a dispensing nozzle 2 for a container of wipes (not shown). The nozzle 2 features an annular projection 14 the inside of which features inward facing spikes 17. The spikes can be made from a flexible elastomer or a non flexible polypropylene material. The spikes 17 feature ‘slit’ sections of weakness that enables the spikes to flex upwardly when subjected to upward pressures from say a wipe (not shown) passing though the structure of the dispensing nozzle 2. If downward forces act on the wipe after it has been inserted into the nozzle so as to force the wipe 4 back into its container, two things happen. 1) The spikes 17 or spikes flex back to their original position thereby imposing space restrictions within the annular projection that imped wipe fall back. 2) The ends 20 of the spikes 17 dig into the wipe thereby impeding wipe fall back still further.

Abstract: Various embodiments herein relate to electrochromic windows that are bird friendly, as well as methods and apparatus for forming such windows. Bird friendly windows include one or more elements that make the window visible to birds so that the birds recognize that they cannot fly through the window. Bird friendly windows can be used to minimize avian-window collisions, and therefore minimize avian deaths resulting from such collisions. In various embodiments, a window may be patterned such that the pattern is visible to birds. In these or other cases, the window may be made hazy, where the haze is visible to birds. The pattern and/or haze may be visible at wavelengths that fall in UV, and minimally noticeable (if at all) in wavelengths within the spectrum visible by humans.

Abstract: A radiofrequency filter utilizing a common mode choke both as a traditional common mode choke as well as the inductance in a low pass filter. Filter topology as well as component selection is optimized for wide band operation. Common mode chokes allow differential currents to pass with little attenuation while common mode currents are effectively presented with an inductance in the common current path. This inductance is used in a low pass filter configuration to present an even higher attenuation to common mode currents. The use of multiple chokes and/or differing core materials contributes to wider band operation without pronounced resonances. The capacitance used in the low pass filter is connected in a way as to reduce its effect on the data signals while still being effective in filtering.

Abstract: The invention relates to a dispensing nozzle 2 for a container of wipes (not shown). The nozzle 2 features an annular projection 14 the inside of which features inward facing spikes 17. The spikes can be made from a flexible elastomer or a non flexible polypropylene material. The spikes 17 feature ‘slit’ sections of weakness that enables the spikes to flex upwardly when subjected to upward pressures from say a wipe (not shown) passing though the structure of the dispensing nozzle 2. If downward forces act on the wipe after it has been inserted into the nozzle so as to force the wipe 4 back into its container, two things happen. 1) The spikes 17 or spikes flex back to their original position thereby imposing space restrictions within the annular projection that imped wipe fall back. 2) The ends 20 of the spikes 17 dig into the wipe thereby impeding wipe fall back still further.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A slide fastener reinforcing strap for securing across an opening formed between first and second tapes of a slide fastener is provided. The slide fastener reinforcing strap extends from a first end to a second end along a centerline. The slide fastener reinforcing strap includes a first protrusion between the first and second ends. The first protrusion extends in a first direction which is perpendicular to the centreline.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.