Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A putter head having an adjustable sole plate which is positionable to contact a playing surface and adjust the height of a face of the putter head to varying distances above the playing surface and thereby vary the position of the putter head relative to a ball being struck thereby. Horizontal grooves and diagonal grooves depending into the face may be included in the putter head. Weight and center of gravity of the putter head is adjustable using weights which engage within weight sockets depending into the putter head.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: The invention relates to processes for separating metals, and in particular for separating precious metals such as platinum and palladium, by solvent extraction. The invention also provides novel solvent extraction mixtures useful in the processes of the invention. The inventors have found that by simultaneously employing different extraction mechanisms for the extraction of a plurality of different metals, a simple and convenient process for their separation can be achieved. In particular, the inventors have found that the use of different extraction mechanisms for simultaneously extracting metals from an aqueous acidic phase into an organic phase enables the extracted metals to be separated by selective stripping from the organic phase using simple and mild conditions. This process is particularly advantageous as it permits two or more metals to be separated following a single solvent extraction step, because of the ability to selectively strip the metals from the organic phase.

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A radiofrequency filter utilizing a common mode choke both as a traditional common mode choke as well as the inductance in a low pass filter. Filter topology as well as component selection is optimized for wide band operation. Common mode chokes allow differential currents to pass with little attenuation while common mode currents are effectively presented with an inductance in the common current path. This inductance is used in a low pass filter configuration to present an even higher attenuation to common mode currents. The use of multiple chokes and/or differing core materials contributes to wider band operation without pronounced resonances. The capacitance used in the low pass filter is connected in a way as to reduce its effect on the data signals while still being effective in filtering.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: Various embodiments herein relate to electrochromic windows that are bird friendly, as well as methods and apparatus for forming such windows. Bird friendly windows include one or more elements that make the window visible to birds so that the birds recognize that they cannot fly through the window. An electrochromic window includes one or more transparent substrates, wherein at least one of the substrates is an electrochromic (EC) lite including an electrochromic device and a pattern formed on at least one of the substrates by a laser, the pattern including a first feature configured to provide a set of optical properties different than optical properties of the transparent substrate. The set of optical properties includes one or more characteristics of refractivity, reflectivity and diffraction.

Abstract: The technology described in this document can be embodied in a computer-implemented method of controlling a wearable audio device configured to provide an audio output. The method includes receiving data indicating the wearable audio device is proximate a geographic location associated with a localized audio message, and determining that the localized audio message has a higher priority compared to at least one other localized audio message associated with another geographical location proximate to the wearable audio device. The method also includes, responsive to determining that the localized audio message has the higher priority, providing a prompt to initiate playback of the localized audio message with the higher priority to a user of the wearable audio device, and initiating playback of the localized audio message with the higher priority at the wearable audio device in response to actuation of the prompt by the user.

Abstract: Various implementations include wearable audio devices and related methods for controlling such devices. In some particular implementations, a computer-implemented method of controlling a wearable audio device configured to provide an audio output includes: receiving data indicating the wearable audio device is proximate a geographic location associated with a localized audio message; inserting audio content associated with a brand into an identified portion of the localized audio message; and initiating playback of the localized audio message including the inserted audio content associated with the brand at the wearable audio device.

Abstract: A software tool includes a plurality of pre-coded API sensor modules for obtaining information from the sensors coupled to a mobile device and a pre-coded API audio module for playing audio content based on the information obtained from at least one of the sensors.

Abstract: The technology described in this document can be embodied in a computer-implemented method of controlling a wearable audio device configured to provide an audio output. The method includes receiving data indicating the wearable audio device is proximate a geographic location associated with a plurality of localized audio messages, and presenting, using one or more user-interfaces, a representation of the plurality of localized audio messages. The method also includes receiving information indicative of a selection of a portion of the one or more user interfaces, and initiating playback of one or more of the plurality of localized audio messages that correspond to the selection, on the wearable audio device.

Abstract: Described are various embodiments of a computerized method and system for automatically developing a facial remediation protocol for a user based on an input facial image of the user, wherein facial remediation design or plan comprises a combination of one or more of a surgical plan to shift or change the size of various facial anatomical features, a makeup plan to change the apparent size or apparent position of various facial anatomical features and other techniques, such as hair design, to reduce the actual and perceived difference between the subject's face and a standard face, for example.

Abstract: A radiofrequency filter utilizing a common mode choke both as a traditional common mode choke as well as the inductance in a low pass filter. Filter topology as well as component selection is optimized for wide band operation. Common mode chokes allow differential currents to pass with little attenuation while common mode currents are effectively presented with an inductance in the common current path. This inductance is used in a low pass filter configuration to present an even higher attenuation to common mode currents. The use of multiple chokes and/or differing core materials contributes to wider band operation without pronounced resonances. The capacitance used in the low pass filter is connected in a way as to reduce its effect on the data signals while still being effective in filtering.

Abstract: An assembly for preventing an overdose of a charged particle beam during therapy to a patient includes a pixelated detector apparatus and a controller. The controller includes, for each pixel: a current integrator circuit that converts the local measured current into a total local detected charge integrated from a start time, the integrator circuit outputting an integrator voltage that corresponds to the total local detected charge; and a discriminator circuit that compares the integrator voltage with a reference voltage, the reference voltage corresponding to a maximum acceptable dose for the patient. A logic circuit generates an overdose fault signal if, at any of the pixels, the integrator voltage is higher than the reference voltage.