Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: Provided herein are compounds comprising a three-ring core, such as compounds of Formula (I), Formula (I-i), Formula (I-A), Formula (I-A-i), Formula (I-A-i-1), Formula (I-B), Formula (I-B-i), Formula (I-B-i-1), Formula (II), Formula (II-i), Formula (II-A), Formula (II-A-i), Formula (II-A-i-1), Formula (II-B), Formula (II-B-i), and Formula (II-B-i-1) and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer.

Abstract: Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with ?1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.

Abstract: This invention relates to a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, a kit for performing the method, and furthermore to isolated nucleotide sequences being complementary to one or more mutations of the CFTR gene. According to a first aspect of the invention there is provided a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, including the steps of providing one or more nucleic acid sequences, fully complementary to one or more segments of the CFTR gene, wherein the one or more nucleic acid sequences correspond to the mutation to be identified; providing a biological sample of an individual to be tested for CF; isolating nucleic acids from the biological sample; and testing the biological sample for the presence of one or more of the nucleic acid sequences using a suitable detection method.

Abstract: A method and system is disclosed for populating a local second line service (“SLS”) database in a telecommunications device (“TD”). The local SLS database is for use by an SLS application that provides a second line service to the user of the TD. To populate the local SLS database, historical data associated with prior use of the TD is mined for relevant information. Relevant information may include, for example, a primary phone number associated with other contact data. Relevant information is then used to populate the local SLS database. The local SLS database is then updated with a relationship number(s) in association with the relevant information. The relationship number enables the SLS application to direct a telecommunication to the primary number via a remote SLS platform.

Abstract: A blast-resistant escape window for an armored combat ground vehicle has a cassette which fits within, and closes, a though-opening in a frame of a windscreen. Two releasable lever-operated locking mechanisms for releasably locking the cassette in the through-opening are mounted on the windscreen at opposite sides of the through-opening. The cassette can to be pushed out of the through-opening when the locking mechanisms have been operated to release the cassette from being locked to the windscreen, thereby providing an alternative exit for personnel in the vehicle.

Abstract: The present application discloses compounds that are inhibitors of Btk, compounds that are inhibitors of PI3K?, and compounds that are dual inhibitors of both Btk and PI3K?. Also described are methods for synthesizing such inhibitors and methods for using such inhibitors for the treatment of diseases wherein inhibition of Btk and PI3K? provides a therapeutic benefit to a patient having the disease.

Abstract: Either during message selection in an industrial printer (e.g. ink jet or laser marking) for printing onto objects carried past it on a conveyor, or during printing, or both, a printer displays an image associated with the message proposed for printing or being printed. The image may be a picture (e.g. a photograph) of the object on which the message should be printed or the intended customer/end user or the intended use of the object on which the message should be printed. Since a human operator can usually identify an object or intended customer/use more quickly and accurately from a picture than from text, this reduces errors in message selection and/or helps the detection of an incorrect message during printing. The image may be displayed with the associated message or without it.

Abstract: A medical implant which comprises a porous lattice is fabricated with additive manufacturing techniques such as direct metal laser sintering. A CAD model of the porous lattice is created by defining a trimming volume and merging some lattice elements with adjacent solid substrate.

Abstract: A communication system can provide an independent mobile cellular network to devices within a covered area. In addition, the system can determine whether user equipment within a covered area of the communication system are to have backhaul access to another communication system and/or whether to adjust the point of presence of the user equipment.

Abstract: Enhanced capabilities within a telephone network are made accessible to a telecommunications device. The telecommunications device is used to dial a sequence. A network server receives and identifies the sequence invokes an advanced network function. A advanced network function server in communication with the network server provides instructions as to how the network server is to provide the advanced network function. The network server processes the call in accordance with the received instructions to provide the particular advanced network function.

Abstract: The present application provides systems and methods for a mobile storefront having direct customer access to inventory and pricing from a mobile storefront. In particular, systems and methods provide an application usable by customers to purchase goods or services from a mobile storefront through an electronic communication device. This includes reserving and purchasing products in inventory of the mobile storefront or pooled inventory from multiple mobile storefronts in an area, reserving and purchasing services and/or support, and for communicating directly with an electronic communication device of the mobile storefront.

Abstract: A method and system is disclosed for populating a local second line service (“SLS”) database in a telecommunications device (“TD”). The local SLS database is for use by an SLS application that provides a second line service to the user of the TD. To populate the local SLS database, historical data associated with prior use of the TD is mined for relevant information. Relevant information may include, for example, a primary phone number associated with other contact data. Relevant information is then used to populate the local SLS database. The local SLS database is then updated with a relationship number(s) in association with the relevant information. The relationship number enables the SLS application to direct a telecommunication to the primary number via a remote SLS platform.