Abstract: A modular augment cone system and methods of implanting the modular augment cone system. The system includes a main body cone a first cutout in the cone wall, and including a proximal end, a distal end, and a cone wall extending between the proximal and distal ends. A portion of the cone wall proximal to the first cutout includes an attachment feature. A first augment cone is positionable in the first cutout, the first augment cone including an attachment feature configured to mate with the attachment feature of the cone wall to attach the first augment cone into the first cutout. The main body cone can include a second cutout in the cone wall. In such systems, the modular augment cone system can include a second augment cone configured to mate with an attachment feature of the cone wall to attach the second augment cone into the second cutout.

Abstract: A system for the management and reporting of serviceability at stores, restaurants, museums, entertainment venues or other locations 130, 140, 150, 160 is disclosed. The system comprises a serviceability information aggregator 125 working in conjunction with serviceability information agents which take the form of apps operating on smart phones, tablets, smart watches or other devices. The serviceability information aggregator 125 receives information from users 120 operating serviceability information agents related to serviceability parameters, such as wait time, line lengths, parking availability, or crowd size, aggregates the information into a serviceability score or scores, and communicates those on request to one or more users 120 via the application agent.

Abstract: This invention relates to a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, a kit for performing the method, and furthermore to isolated nucleotide sequences being complementary to one or more mutations of the CFTR gene. According to a first aspect of the invention there is provided a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, including the steps of providing one or more nucleic acid sequences, fully complementary to one or more segments of the CFTR gene, wherein the one or more nucleic acid sequences correspond to the mutation to be identified; providing a biological sample of an individual to be tested for CF; isolating nucleic acids from the biological sample; and testing the biological sample for the presence of one or more of the nucleic acid sequences using a suitable detection method.

Abstract: The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlogumine; and use of the derivatives and analogs for treating cancer.

Abstract: Enhanced capabilities within a telephone network are made accessible to a telecommunications device. The telecommunications device is used to dial a sequence. A network server receives and identifies the sequence invokes an advanced network function. A advanced network function server in communication with the network server provides instructions as to how the network server is to provide the advanced network function. The network server processes the call in accordance with the received instructions to provide the particular advanced network function.

Abstract: The present application provides systems and methods for a mobile storefront having direct customer access to inventory and pricing from a mobile storefront. In particular, systems and methods provide an application usable by customers to purchase goods or services from a mobile storefront through an electronic communication device. This includes reserving and purchasing products in inventory of the mobile storefront or pooled inventory from multiple mobile storefronts in an area, reserving and purchasing services and/or support, and for communicating directly with an electronic communication device of the mobile storefront.

Abstract: Multiple mobile cellular network (MCN) communication systems can be networked together to form a network of MCN communication systems (NOM). Each MCN communication system within the NOM can operate as an independent cellular network to provide communications between user equipment within a covered area. When a UE in one MCN of the NOM moves into a different MCN of the NOM, the corresponding MCN communication systems can handover the UE. The UE can also be handed over between MCN communication systems when the MCN communication systems move.

Abstract: A mobile application and a method are described for servicing a second line service (“SLS”) based communication request originating from a subscriber's telecommunications device (“TD”) even if the call signal does not include sufficient information to identify the phone number from which the subscriber initiated the call. The method involves associating the SLS phone number of the subscriber, the primary number of the subscriber and the primary number of a third party via a special relationship number.

Abstract: Provided herein are compounds comprising a three-ring core, such as compounds of Formula (X), Formula (X-A), Formula (X-Ai), Formula (X-B), Formula (X-Bi), Formula (Z), Formula (Z-A), Formula (Z-Ai), Formula (Z-B), Formula (Z-Bi), Formula (I), Formula (I-A), Formula (I-Ai), Formula (I-B), and Formula (I-Bi), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer.

Abstract: A threaded pipe connection includes a first tubular member having a pin end defining external threads, a second tubular member having a box end defining internal threads threadably engageable with the external threads of the pin end, and a thread profile that defines at least a portion of one of the internal or external threads and includes a crest, a root, and a transition surface extending between the crest and the root. The transition surface includes a first arcuate surface extending from a top of the crest at a first radius, a second arcuate surface extending from the first arcuate surface at a second radius, and a third arcuate surface extending from the second arcuate surface at a third radius. The first radius and the third radius are each smaller than the second radius.

Abstract: A method and system are described for servicing a second line service (“SLS”) based communication request originating from a subscriber's telecommunications device (“TD”) even if the call signal does not include sufficient information to identify the phone number from which the subscriber initiated the call. The method involves associating the SLS phone number of the subscriber, the primary number of the subscriber and the primary number of a third party via a special relationship number.

Abstract: A communication system can provide an independent mobile cellular network to devices within a covered area. In addition, the system can determine whether user equipment within a covered area of the communication system are to have backhaul access to another communication system and/or whether to adjust the point of presence of the user equipment.

Abstract: Multiple mobile cellular network (MCN) communication systems can be networked together to form a network of MCN communication systems (NOM). Each MCN communication system within the NOM can operate as an independent cellular network to provide communications between user equipment within a covered area. When a UE in one MCN of the NOM moves into a different MCN of the NOM, the corresponding MCN communication systems can handover the UE. The UE can also be handed over between MCN communication systems when the MCN communication systems move.

Abstract: Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with ?1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.

Abstract: A ratchet tool apparatus including an elongated tubular shaft member having a drive socket built into the shaft at a distal end and having a worm screw gear attached to the shaft at a proximate end, a worm wheel having mating teeth members that mesh with the worm screw gear, a socket receiving orifice for receiving one of a plurality of socket attachments, a switch mechanism that is manually switched between a left directional mode of operation, a right directional mode of operation and a free spin mode of operation, the switch mechanism including a cover; a plurality of sealed bearings attached to the shaft member to stabilize the motion of the shaft member, and a housing unit having a cavity in which is mounted the elongated shaft member, the worm wheel, the worm screw gear, the socket receiving orifice, the switch mechanism, and the plurality of sealed bearings. The housing unit includes a handle region and a head region, the handle region has a L shape and includes a lever member.

Abstract: Enhanced capabilities within a telephone network are made accessible to a telecommunications device. The telecommunications device is used to dial a sequence. A network server receives and identifies the sequence invokes an advanced network function. A advanced network function server in communication with the network server provides instructions as to how the network server is to provide the advanced network function. The network server processes the call in accordance with the received instructions to provide the particular advanced network function.

Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: A method, system, and computer-program product for handling network partitions in a network is provided. For example, a method can include providing a first compute node and a second compute node on the network. In such an example, the first compute node can include a master instance of a cryptographic database. In addition, the second compute node can include a first synchronous slave instance associated with the master instance. The method can further include identifying a network partition event on the network. The method can further include providing an asynchronous slave instance associated with the master instance and changing the asynchronous slave instance to a second synchronous slave instance in response to identifying the network partition event.