Abstract: Described herein are methods of assessing a sample-specific performance of a copy number variant model, a method for determining a copy number of an interrogated segment within a region of interest, and a method for determining a copy number variant abnormality within a region of interest. Sample-specific performance of the copy number variant caller is assessed by parameterizing a copy number variant model base on sequencing reads from a test sample, generating synthetic copy number variants using the sequencing read from the test sample, and calling the number of copies in the synthetic copy number variants using the copy number variant model and the sample-specific parameters. Calling a number of copies of an interrogated segment can include parameterizing a hidden Markov model using an analytic first derivative gradient and second derivative Hessian of one or more parameters in a copy number likelihood model.

Abstract: In some embodiments, the present invention provides for an exemplary computer system which includes at least the following components: a network of externally owned presence (EOP) member nodes, including a supervisory EOP member node is configured to generate at least one personalized cryptographic private key for each peer EOP member node; a distributed database, storing a plurality of persistent data objects; and a plurality of self-contained self-executing software containers (SESCs); where each SESC includes an independently executable software code which is at least configured to: apply entropy to generate a state hash representative of a current state of a persistent data object, perform a data action with the persistent data object; and determine that a particular EOP member node has a permission to cause the SESC to perform the data action with the persistent data object based.

Abstract: Some embodiments relate to an apparatus for holding a workpiece under tension while one or more operations are performed on the workpiece, the apparatus comprising: a frame; a first spindle rotatably coupled to the frame; a first coupler configured to couple the first spindle to a first end of the workpiece; a second spindle rotatably coupled to the frame; and a second coupler configured to couple the second spindle to a second end of the workpiece; wherein a distance between the first and second couplers is adjustable to hold the workpiece under tension between the couplers while the one or more operations are performed, and wherein the workpiece can be rotated with the couplers relative to the frame about a common axis of rotation extending between the couplers. Some embodiments relate to a system comprising a controller for controlling rotation of the workpiece. Embodiments also relate to processes comprising holding a workpiece under tension while performing one or more operations on the workpiece.

Abstract: In some embodiments, the present invention provides for an exemplary computer system which includes at least the following components: a network of externally owned presence (EOP) member nodes, including a supervisory EOP member node is configured to generate at least one personalized cryptographic private key for each peer EOP member node; a distributed database, storing a plurality of persistent data objects; and a plurality of self-contained self-executing software containers (SESCs); where each SESC includes an independently executable software code which is at least configured to: apply entropy to generate a state hash representative of a current state of a persistent data object, perform a data action with the persistent data object; and determine that a particular EOP member node has a permission to cause the SESC to perform the data action with the persistent data object based.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: In some embodiments, the present invention provides for an exemplary computer system which includes at least the following components: a network of externally owned presence (EOP) member nodes, including a supervisory EOP member node is configured to generate at least one personalized cryptographic private key for each peer EOP member node; a distributed database, storing a plurality of persistent data objects; and a plurality of self-contained self-executing software containers (SESCs); where each SESC includes an independently executable software code which is at least configured to: apply entropy to generate a state hash representative of a current state of a persistent data object, perform a data action with the persistent data object; and determine that a particular EOP member node has a permission to cause the SESC to perform the data action with the persistent data object based.

Abstract: In some embodiments, the present invention provides for an exemplary computer system which includes at least the following components: a network of externally owned presence (EOP) member nodes, including a supervisory EOP member node is configured to generate at least one personalized cryptographic private key for each peer EOP member node; a distributed database, storing a plurality of persistent data objects; and a plurality of self-contained self-executing software containers (SESCs); where each SESC includes an independently executable software code which is at least configured to: apply entropy to generate a state hash representative of a current state of a persistent data object, perform a data action with the persistent data object; and determine that a particular EOP member node has a permission to cause the SESC to perform the data action with the persistent data object based.

Abstract: A system is disclosed for drying a material to liberate a substance such as a liquid having a vapor pressure from solids and/or dissolved substances in the material. The system includes a plenum chamber and a blower providing a stream of air to the plenum chamber. An outlet communicates with the plenum chamber and a velocity accelerator is disposed downstream of the outlet. The velocity accelerator is arranged to receive air from the outlet of the plenum chamber into a progressively narrowing interior passageway terminating at a downstream choke point orifice. The choke point orifice discharges into a larger diameter discharge region. A throttle body is disposed in the discharge region and is selectively movable toward and away from the choke point orifice to decrease or increase the volume of the discharge region. A passageway is formed through the throttle body for receiving flashed material from the discharge region and conveying the material in a downstream direction.

Abstract: Some embodiments relate to an apparatus for holding a workpiece under tension while one or more operations are performed on the workpiece, the apparatus comprising: a frame; a first spindle rotatably coupled to the frame; a first coupler configured to couple the first spindle to a first end of the workpiece; a second spindle rotatably coupled to the frame; and a second coupler configured to couple the second spindle to a second end of the workpiece; wherein a distance between the first and second couplers is adjustable to hold the workpiece under tension between the couplers while the one or more operations are performed, and wherein the workpiece can be rotated with the couplers relative to the frame about a common axis of rotation extending between the couplers. Some embodiments relate to a system comprising a controller for controlling rotation of the workpiece. Embodiments also relate to processes comprising holding a workpiece under tension while performing one or more operations on the workpiece.

Abstract: A computer-implemented method for optimizing performance of a DNA-based noninvasive prenatal screen includes generating a plurality of synthetic sequencing datasets by, for each of the plurality of synthetic sequencing datasets, (i) generating at least one of a plurality of synthetic copy number variants comprising a synthetic number of copies of at least a portion of a region of interest represented by a synthetic number of sequencing reads from one or more segments within the region of interest, and (ii) modifying a real sequencing dataset, which includes genetic sequencing data from a real test sample comprising maternal and fetal cfDNA, by replacing a number of real sequencing reads from the one or more segments within the region of interest in the real test sample with the synthetic number of sequencing reads. Various other methods and systems are also disclosed.

Abstract: In some embodiments, the present invention provides for an exemplary computer system which includes at least the following components: a network of externally owned presence (EOP) member nodes, including a supervisory EOP member node is configured to generate at least one personalized cryptographic private key for each peer EOP member node; a distributed database, storing a plurality of persistent data objects; and a plurality of self-contained self-executing software containers (SESCs); where each SESC includes an independently executable software code which is at least configured to: generate a state hash representative of a current state of a persistent data object, perform a data action with the persistent data object; and determine that a particular EOP member node has a permission to cause the SESC to perform the data action with the persistent data object based.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A system is disclosed for drying a material to liberate a substance such as a liquid having a vapor pressure from solids and/or dissolved substances in the material. The system includes a plenum chamber and a blower providing a stream of air to the plenum chamber. An outlet communicates with the plenum chamber and a velocity accelerator is disposed downstream of the outlet. The velocity accelerator is arranged to receive air from the outlet of the plenum chamber into a progressively narrowing interior passageway terminating at a downstream choke point orifice. The choke point orifice discharges into a larger diameter discharge region. A throttle body is disposed in the discharge region and is selectively movable toward and away from the choke point orifice to decrease or increase the volume of the discharge region. A passageway is formed through the throttle body for receiving flashed material from the discharge region and conveying the material in a downstream direction.

Abstract: A system is disclosed for drying a material to liberate a substance such as a liquid having a vapor pressure from solids and/or dissolved substances in the material. The system includes a plenum chamber and a blower providing a stream of air to the plenum chamber. An outlet communicates with the plenum chamber and a velocity accelerator is disposed downstream of the outlet. The velocity accelerator is arranged to receive air from the outlet of the plenum chamber into a progressively narrowing interior passageway terminating at a downstream choke point orifice. The choke point orifice discharges into a larger diameter discharge region. A throttle body is disposed in the discharge region and is selectively movable toward and away from the choke point orifice to decrease or increase the volume of the discharge region. A passageway is formed through the throttle body for receiving flashed material from the discharge region and conveying the material in a downstream direction.

Abstract: A control system and method for controlling a plant based on feedback is described. In some embodiments, the control system uses pulse-modulated (PM) control to overcome friction stickiness.

Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition and then recovering the oil from the lysed cell composition. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.

Abstract: Embodiments of the invention provide a system and method for generating a lease-purchase agreement including a non-transitory computer-readable medium with software instructions a processor configured to execute the software instructions to cause the system to couple to a front end client including a customer interface including an approval and order session, to process a customer application by verifying a customer in the approval session, and switching to the order session to enable an approved customer to select a good, review an estimate, select a payment option, and order a good. The customer can review an initial and monthly payment, optionally select a user-definable early purchase option payment amount if applicable, and sign a lease agreement generated by the system. The front end client can be a web coupled device, where the approval and order sessions transmit over the Internet, or a kiosk device that displays the approval and order sessions.