Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: Methods and systems are disclosed for drying a material or, more generally, flash evaporating a target substance having a vapor pressure threshold. The methods and systems include a conveyor conduit that receives material and within which a pressure is established that is greater than the vapor pressure threshold of the target substance. The material moves through the conveyor and is expelled into a pressure drop zone created by one or more venturi nozzles. The pressure in the pressure drop zone is far less than the vapor pressure threshold of the target substance. As the material encounters the pressure drop zone, the targeted substance in the material experiences a rapid and extreme pressure drop and simultaneously a rapid temperature increase. This causes the target substance in the material to flash evaporate virtually immediately. The resulting vapor is separated from the remaining material and the now dry material is collected for further processing or use.

Abstract: A method of modeling a jurisdiction provides jurisdiction resilience information and jurisdiction impact information. The method models a jurisdiction system by determining the multiple different systems present in a particular jurisdiction. The method determines the assets of the multiple different systems and stores asset information describing the respective assets of the multiple different systems in a jurisdiction meta-model. The method may determine critical paths across the different systems of the jurisdiction and identify those critical paths across different systems in the jurisdiction meta-model. The method may also determine cascading effects of incidents to assets within each system and identify those cascading effects within each system in the jurisdiction meta-model. The method may also determine cross-cascading effects of incidents to assets across different systems of the jurisdiction and identifying those cross-cascading effects in the jurisdiction meta-model.

Abstract: A method of modeling a jurisdiction provides jurisdiction resilience information and jurisdiction impact information. The method models a jurisdiction system by determining the multiple different systems present in a particular jurisdiction. The method determines the assets of the multiple different systems and stores asset information describing the respective assets of the multiple different systems in a jurisdiction meta-model. The method may determine critical paths across the different systems of the jurisdiction and identify those critical paths across different systems in the jurisdiction meta-model. The method may also determine cascading effects of incidents to assets within each system and identify those cascading effects within each system in the jurisdiction meta-model. The method may also determine cross-cascading effects of incidents to assets across different systems of the jurisdiction and identifying those cross-cascading effects in the jurisdiction meta-model.

Abstract: The disclosed embodiments generally relate to non-destructive evaluation methods. More particularly, the disclosed embodiments relate to ultrasonic non-destructive evaluation methods for the evaluation of friction welded bladed discs (“blisks”). In an embodiment, a method for non-destructive evaluation of a bladed disc structure includes identifying a region of interest on the bladed disc structure; positioning an ultrasonic transducer and receiver in the region of interest; scanning the region of interest using the ultrasonic transducer and receiver to produce a scan image; and comparing the scan image against a reference image to determine the presence of an anomaly in the region of interest.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates.

Abstract: A gimbal assembly of a single or dual stage actuator is provided with a layer of Diamond-Like Carbon (DLC) as a middle layer at a tongue/dimple interface where a dimple of a supporting loadbeam contacts a tongue on the gimbal assembly. Using the DLC at the tongue/dimple interface greatly reduces the amount of fretting wear particles formed during operation of the microactuator. The reduced wear at the dimple/gimbal interface may provide more stable dynamics over time. The DLC middle layer may be applied on the tongue, or on the tongue only at the tongue/dimple interface, or the DLC may be applied to the dimple.

Abstract: Methods and systems are disclosed for drying a material or, more generally, flash evaporating a target substance having a vapor pressure threshold. The methods and systems include a conveyor conduit that receives-material and within which a pressure is established that is greater than the vapor pressure threshold of the target substance. The material moves through the conveyor and is expelled into a pressure drop zone created by one or more venturi nozzles. The pressure in the pressure drop zone is far less than the vapor pressure threshold of the target substance. As the material encounters the pressure drop zone, the targeted substance in the material experiences a rapid and extreme pressure drop and simultaneously a rapid temperature increase. This causes the target substance in the material to flash evaporate virtually immediately. The resulting vapor is separated from the remaining material and the now dry material is collected for further processing or use.

Abstract: A system is disclosed for drying a material to liberate a substance such as a liquid having a vapor pressure from solids and/or dissolved substances in the material. The system includes a plenum chamber and a blower providing a stream of air to the plenum chamber. An outlet communicates with the plenum chamber and a velocity accelerator is disposed downstream of the outlet. The velocity accelerator is arranged to receive air from the outlet of the plenum chamber into a progressively narrowing interior passageway terminating at a downstream choke point orifice. The choke point orifice discharges into a larger diameter discharge region. A throttle body is disposed in the discharge region and is selectively movable toward and away from the choke point orifice to decrease or increase the volume of the discharge region. A passageway is formed through the throttle body for receiving flashed material from the discharge region and conveying the material in a downstream direction.

Abstract: Methods and systems are disclosed for drying a material or, more generally, flash evaporating a target substance having a vapor pressure threshold. The methods and systems include a conveyor conduit that receives material. The material moves through the conveyor and is expelled into a pressure drop zone created by one or more venturi nozzles. As the material encounters the pressure drop zone, the targeted substance in the material experiences a rapid and extreme pressure drop and simultaneously a rapid temperature increase. This causes the target substance in the material to flash evaporate virtually immediately. The resulting vapor is separated from the remaining material and the now dry material is collected for further processing or use. The vapor can be collected, condensed, exhausted, or otherwise treated depending upon the goals of a particular installation or process.

Abstract: The disclosed embodiments generally relate to non-destructive evaluation methods. More particularly, the disclosed embodiments relate to ultrasonic non-destructive evaluation methods for the evaluation of friction welded bladed discs (“blisks”). In an embodiment, a method for non-destructive evaluation of a bladed disc structure includes identifying a region of interest on the bladed disc structure; positioning an ultrasonic transducer and receiver in the region of interest; scanning the region of interest using the ultrasonic transducer and receiver to produce a scan image; and comparing the scan image against a reference image to determine the presence of an anomaly in the region of interest.

Abstract: A persistent connection may be established between a first and second computing device based on a signal received by the first computing device from the second computing device, where the second computing device is protected by a protective mechanism that blocks unauthorized signals from reaching the second computing device and the signal from the second computing device is allowed by the protective mechanism. A command signal may be sent to the second computing device over the persistent connection, and an exchange of conferencing transmissions may be orchestrated by the first computing device between the second computing device and other computing devices connected to the first computing device.

Abstract: Emergency lubrication systems and methods for an engine are provided. One system includes a primary lubrication system including a de-aeration oil tank configured to store de-aerated oil until the oil is de-aerated, a first oil supply line configured to provide de-aerated oil to the engine, and a first valve configured to control the flow of oil through the primary lubrication system. The system further includes a secondary lubrication system including a second valve coupled to the de-aeration oil tank and configured to control the flow of oil through the secondary lubrication system, and a second oil supply line coupled to the engine and to the de-aeration oil tank via the second valve. One method includes the steps of detecting a predetermined event in the engine, preventing the aerated oil from entering the primary lubrication system, and using the aerated oil in the secondary lubrication system to lubricate the engine.

Abstract: Methods and systems are disclosed for drying a material or, more generally, flash evaporating a target substance having a vapor pressure threshold. The methods and systems include a conveyor conduit that receives material. The material moves through the conveyor and is expelled into a pressure drop zone created by one or more venturi nozzles. As the material encounters the pressure drop zone, the targeted substance in the material experiences a rapid and extreme pressure drop and simultaneously a rapid temperature increase. This causes the target substance in the material to flash evaporate virtually immediately. The resulting vapor is separated from the remaining material and the now dry material is collected for further processing or use. The vapor can be collected, condensed, exhausted, or otherwise treated depending upon the goals of a particular installation or process.

Abstract: The present invention relates to a process for the manufacture of a compound of the Formula IIa: wherein R is a suitable sulphonate ester; from a (C1-C6)alkyl-4-piperidinecarboxylate compound of the Formula III:

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A PM system for overcoming friction stickiness and which also remains stable is described.

Abstract: An attachable wing for an aircraft is disclosed. The attachable wing is configured to mount to the underside of the fuselage of an aircraft, such as a rotary wing aircraft (e.g., a helicopter) or a fixed wing aircraft. The attachable wing produces additional lift, which results in an increase in speed, and consequently, an increase in fuel efficiency and payload capacity. In some embodiments, the attachable wing is retractable to facilitate takeoffs and landings. Additionally, the apparatus may be made of a bulletproof or anti-ballistic material to protect the aircraft from incoming fire or crash damage. The airfoil apparatus provides additional lift, allowing for greater fuel efficiency and range of the aircraft on which it is installed.

Abstract: A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R2, R3, R4 and R5 are organic groups as defined in the specification, which process comprises aromatisation of a compound of formula (III) where R1, R2, R3, n, X and R5 are as defined in relation to formula (II) and R4? is a group R4 or a precursor group thereof, and thereafter if necessary or desired, carrying out one or more of the following steps: (i) removing any hydroxy-protecting groups R; (ii) converting a precursor group R4? to a group R4, or where R4? is a group R4, converting it to a different such group. Compounds obtained are useful intermediates for example in the preparation of fulvestrant. Novel intermediates are also claimed.