Patents by Inventor John Howard

John Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AUTOTAXIN INHIBITORS AND USES THEREOF
    Publication number: 20180147185
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 31, 2018
    Applicant: PharmAkea, Inc.
    Inventors: Gretchen BAIN, Jillian Frances EVANS, John Howard HUTCHINSON, David LONERGAN
  • CONTROLLING IN FLIGHT ENTERTAINMENT SYSTEM USING POINTING DEVICE INTEGRATED INTO SEAT
    Publication number: 20180148174
    Abstract: An entertainment system includes a video display unit facing a passenger seat and a track pad assembly integrated with an armrest of the passenger seat. The track pad assembly includes a track pad that is operable to control the video display unit.
    Type: Application
    Filed: January 24, 2018
    Publication date: May 31, 2018
    Inventors: Jeffrey S. Everhart, Lori Elizabeth Salazar, John Howard Darvell
  • TOBACCO-CONTAINING SMOKING ARTICLE
    Publication number: 20180146713
    Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.
    Type: Application
    Filed: January 24, 2018
    Publication date: May 31, 2018
    Inventors: John Howard Robinson, David William Griffith, Billy Tyrone Conner, Evon Llewellyn Crooks, Dempsey Bailey Brewer
  • METHOD AND APPARATUS FOR REINFORCING A CABLE USED IN HIGH FREQUENCY APPLICATIONS
    Publication number: 20180130576
    Abstract: A method and apparatus of reinforcing a cable includes wrapping a flexible wire around at least a portion of an external surface of the cable, and soldering the flexible wire to the cable, thereby positioning the flexible wire with respect to the cable. The portion of the external surface of the cable wrapped with the flexible wire may be disposed between the cable and a connector, or represent an entire length of the cable. Wrapping the flexible wire may involve wrapping the flexible wire around a portion of the external surface of the cable such that coils of the flexible wire are disposed apart from each other, and sliding the coils together such that the coils of the flexible wire are touching each other.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 10, 2018
    Inventor: John Howard
  • Heterocyclic vinyl autotaxin inhibitor compounds
    Patent number: 9951026
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: April 24, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, Timothy Andrew Parr, Kevin Duane Bunker, David Lonergan
  • Regulatory region having increased expression and method of using same
    Patent number: 9944937
    Abstract: An enhanced globulin-1 regulatory region is shown, a nucleotide sequence of which includes at least one additional copy of a region of the globulin-1 regulatory region which includes at least one transcriptional factor binding domain, combined with a transcription initiation site and translation start site. The promoter provides improved seed preferred, and particularly embryo preferred expression in plants. Methods of use are also shown in preferentially expressing a heterologous protein to the embryo tissue of a plant.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 17, 2018
    Assignee: Applied Biotechnology Institute, Inc.
    Inventors: John Howard, Celine Hayden
  • Video display unit cassette assemblies for aircraft seats and enhanced in flight entertainment user experience
    Patent number: 9938014
    Abstract: A video display unit cassette assembly includes a cassette frame, a display coupled to the cassette frame, one or more electronic components between the cassette frame and the display, and a delethalization cover coupled to the display. The one or more electronic components receive data content from a network and generate video signals provided to the display. The cassette assembly is sized and configured to be releasably mounted in an installed position in a mounting structure defined in a seatback of a vehicle seat.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: April 10, 2018
    Assignee: THALES AVIONICS, INC.
    Inventors: Jeffrey S. Everhart, Lori Elizabeth Salazar, John Howard Darvell
  • PROCESS FOR SEPARATING PARTICLES CONTAINING ALKALI METAL SALTS FROM LIQUID HYDROCARBONS
    Publication number: 20180094198
    Abstract: The present technology provides a process that includes heating a first mixture of elemental sulfur and particles comprising an alkali metal sulfide in a liquid hydrocarbon to a temperature of at least 150° C., to provide a sulfur-treated mixture comprising agglomerated particles; and separating the agglomerated particles from the sulfur-treated mixture to provide a desulfurized liquid hydrocarbon and separated solids. This process may be used as part of a suite of processes for desulfurizing liquid hydrocarbons contaminated with organosulfur compounds and other heteroatom-based contaminants. The present technology further provides processes for converting carbon-rich solids (e.g., petroleum coke) into fuels.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 5, 2018
    Inventors: Michael ZENAITIS, Mykola MAKOWSKY, John Howard GORDON, Jeff KILLPACK
  • Tetracyclic autotaxin inhibitors
    Patent number: 9926318
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 27, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, David Lonergan, Martin Rowbottom, Andiliy Gokching Lai
  • Substituted pyrimidines for inhibiting Raf kinase activity
    Patent number: 9920048
    Abstract: The present invention provides methods of inhibiting Raf kinase activity in a patient, the method comprising administering to the patient a compound having formula I: or a pharmaceutically acceptable salt thereof, wherein Rx, Ry, R1, L1, L2, Cy1, and Cy2 are as defined as set forth in the specification.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 20, 2018
    Assignees: Millennium Pharmaceuticals, Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Weirong Chen, Jennifer Cossrow, Lloyd Franklin, Bing Guan, John Howard Jones, Gnanasambandam Kumaravel, Benjamin Lane, Adam Littke, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Controlling in flight entertainment system using pointing device integrated into seat
    Patent number: 9908626
    Abstract: An entertainment system includes a video display unit facing a passenger seat and a track pad assembly integrated with an armrest of the passenger seat. The track pad assembly includes a track pad that is operable to control the video display unit.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: March 6, 2018
    Assignee: Thales Avionics, Inc.
    Inventors: Jeffrey S. Everhart, Lori Elizabeth Salazar, John Howard Darvell
  • LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20180057458
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: March 1, 2018
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, David LONERGAN
  • UAV FUEL AND LUBRICATION SYSTEM
    Publication number: 20180057185
    Abstract: An unmanned aerial vehicle has an internal combustion engine, and a fuel and lubrication system comprising a fuelling system for fuelling the engine and a lubrication system for delivering lubricating oil to the engine. The fuelling system comprises a fuel reservoir from which fuel can be delivered to the engine. The fuel reservoir comprises a main tank and a header tank. The lubrication system comprises an oil tank. The oil tank is accommodated internally within the main tank to provide an integrated assembly. The arrangement provides for warming of lubrication oil for the UAV engine using several available heat sources. Further, the arrangement facilitates a configuration and layout intended to minimise or negate any undesirable moments of inertia for the UAV during flight as fuel and oil is consumed.
    Type: Application
    Filed: February 19, 2016
    Publication date: March 1, 2018
    Applicant: ORBITAL AUSTRALIA PTY LTD
    Inventors: Geoffrey Paul CATHCART, Stephen John KARAY, Nicholas COPLIN, John Howard TUBB, Callan Murray BLEECHMORE, Donald Andrew RAILTON, Mario Charles MUSCAT
  • Tobacco-containing smoking article
    Patent number: 9901123
    Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: February 27, 2018
    Assignee: RAI Strategic Holdings, Inc.
    Inventors: John Howard Robinson, David William Griffith, Jr., Billy Tyrone Conner, Evon Llewellyn Crooks, Dempsey Bailey Brewer, Jr.
  • Ultra-broadband antenna array with constant beamwidth throughout operating frequency band
    Patent number: 9905936
    Abstract: An antenna array includes a plurality of antenna elements coupled in a common area and extending radially outward from the common area. At least one of the plurality of antenna elements includes a first antenna portion and a second antenna portion arranged in a configuration such that a gap is formed between the first antenna portion and the second antenna portion. The gap includes first spacing associated with a first operating frequency and a first operating wavelength, and a second spacing associated with a second operating frequency and a second operating wavelength. A proportion of the first spacing to the first wavelength is substantially equal to a proportion of the second spacing to the second wavelength, thereby providing a constant beamwidth over an operating frequency band. A method of arranging a plurality of antenna elements in an antenna array is also disclosed.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: February 27, 2018
    Inventor: John Howard
  • Fluidic Medical Devices and Uses Thereof
    Publication number: 20180045649
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.
    Type: Application
    Filed: August 29, 2017
    Publication date: February 15, 2018
    Inventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
  • DEVICE AND METHOD FOR WOUND THERAPY
    Publication number: 20180028729
    Abstract: A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.
    Type: Application
    Filed: September 22, 2017
    Publication date: February 1, 2018
    Inventors: Ashok V. Joshi, John Howard Gordon, Sai Bhavaraju, Troy C. Dayton, Jeremy Heiser
  • Multi-path analog-to-digital and digital-to-analog conversion of PDM signals
    Patent number: 9871530
    Abstract: An analog-to-digital and digital-to-analog conversion system using pulse-density-modulation (PDM) digital signals which minimize noise and optimize dynamic range by dividing a signal into multiple parallel pathways by apportioning a least significant range portion of an incoming signal to a low-path circuit and a most-significant portion of the incoming signal to a high-path circuit. The high-path circuit and low-path circuit can be separately level-modified to optimize dynamic range. Embodiments of the system can include an analog-to-digital conversion, a digital-to-analog conversion, or a complete analog-to-digital and digital-to-analog conversion system.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: January 16, 2018
    Inventor: John Howard La Grou
  • FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20170369443
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 28, 2017
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Imelda CALDERON
  • Autotaxin inhibitors and uses thereof
    Patent number: 9849109
    Abstract: Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: December 26, 2017
    Assignee: AMIRA PHARMACEUTICALS, INC.
    Inventors: Jeffrey Roger Roppe, Timothy Andrew Parr, Nicholas Simon Stock, Deborah Volkots, John Howard Hutchinson